Marcus Hartmann

137 posts

Marcus Hartmann

@HartmannLab

Structural Biochemistry @MPI_Bio & @UNI_TUE Understanding and Manipulating Molecular Machines

Tuebingen, Germany 加入时间 Haziran 2020

93 关注171 粉丝

置顶推文

Marcus Hartmann@HartmannLab·8 Kas

1/4 Very happy to share the short history about how we discovered a natural #degron of #cereblon @BBRCME. We show how #CRBN specifically recognizes C-terminal cyclic imides as protein damage markers. Shout-out to Chris @NanoTemper & the Schwarzer group! sciencedirect.com/science/articl…

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Hakim@hakim034·7 May

Pleased to share our collaborative effort to develop anti-virulence agents. We unveiled a series of compounds targeting the transcriptional regulator HilD. Feedback is welcome!

bioRxiv Microbiology@biorxiv_micrbio

Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity biorxiv.org/cgi/content/sh… #biorxiv_micrbio

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Mohammad ElGamacy@m_elgamacy·6 May

We just released the "protein design toolkit", integrating tools from Damietta, ProteinMPNN and OpenMM. An interactive tutorial is available at the server damietta.de. Recommended usage is described in the paper: doi.org/10.1093/nar/gk… and feedback is most welcome!

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Marcus Hartmann@HartmannLab·2 Kas

Check out our optimized natural #CRBN degron inspired #PROTACs!

Christian Steinebach@c_steinebach

🚀 New Study Alert! Our benzamide-type CRBN binders redefine PROTAC design. The non-phthalimide scaffold led to: ✅ Enhanced chemical stability ✅ Minimized neomorphic effects ✅ Potent BRD4 & HDAC6 degraders 🌐 Read our full study: t.ly/wssye #MedChem #PROTACs

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Max Planck Society@maxplanckpress·3 Eki

😁🎉😄🌟#NobelPrize!🙃🙃🙃🙃🙃🙃🙃🙃🙃🙃🙃😊🏆😁#PhysicsNobelPrize2023 for Ferenc Krausz, Max Planck Institute of Quantum Optics! 🎊😃🥰😆🥳😁😃🎉🏅😊🎈😁🥳😄🎊😁🌟😃🥰🏆😁🎉🎇😊🥳😄🌟🎈😁😃🥰🎉🏆😁🎊😊😄🥳🌟🎇😁🥰😃🎉🎈😁🏆😊😄🎊🥳😁🌟😃🥰🎉🏅😁🎈😊🥳😄🎉😁😍😁🎉🎇😊🥳😄🌟🎈🏆

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Marcus Hartmann@HartmannLab·21 Eyl

Sleeves up for infection research: Our postdoc Joe Joiner researches anti-infectives to prevent #Salmonella infection. He’s not only appreciated as a talented researcher, but also as a great teacher by his students! @PAW_Germany #PostDocAppreciationWeek @MPI_Bio

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Christian Steinebach@c_steinebach·12 May

It’s #FluorescenceFriday so some #RealTimeChem from my lab: purification (until battery crashed) of a fluorescently labelled non-chiral, non-glutarimide/uracile CRBN ligand with outstanding affinity. #TPD tweeps, it will blow your mind 🤯 next step: in vitro assays @HartmannLab

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Christian Steinebach@c_steinebach·22 Nis

📢New preprint: multidimensional design of benzamide CRBN binders & #PROTACs - #TPD tweeps will surely enjoy the MedChem journey: binding data, X-ray structures, reactivity screens, neosubstrate-sparing degraders, cool synthetic methods. 1/4 👉 ChemRxiv doi.org/10.26434/chemr…

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Khaled A. Selim@Selim_Khaled_·6 Mar

A press release about our recent paper in @PNASNews pnas.org/doi/10.1073/pn… Cyanobacterial protein integrates the circadian clock information growkudos.com/publications/1… via @growkudos @uni_tue_exstra @CoE_CMFI @MPI_Bio

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Christian Steinebach@c_steinebach·8 Mar

Great to see this out! Enormous MedChem efforts led to new SAR aspects of VHL ligands 🧪💊 #TPD bigs thanks to @alessiociulli +team & @IzidorSosic +team and colleagues from @UniBonn

Alessio Ciulli@alessiociulli

Very happy to see our @CeTPD_Dundee collaboration with Michael Gütschow @UNBonn and co on VHL ligand optimization our as preprint. The team expanded structure-activity relationships at the right-hand side biaryl group, improving potency over current benchmark VHL inhibitor VH298

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Vikram Alva@Vikram_Alva·1 Mar

Fun fact: At 1.06 Å, this is the first-ever structure of any histone protein determined at atomic resolution - for what it's worth! 🤣 doi.org/10.1101/2023.0…

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Vikram Alva@Vikram_Alva·1 Mar

Congrats, truly seminal work! Since our initial discovery of bacterial histones, we too worked on the very same histone protein & now present its crystal structure & DNA-binding properties. Great work by Yimin, Birte & collaborators @HartmannLab @MPI_Bio doi.org/10.1101/2023.0…

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Ingo Hartung@HartungIngo·24 Şub

An excellent perspective by authors from @AstraZeneca about fragment-based approaches to identify ligands for E3 ligases. Of especially high relevance for the field of targeted protein degradation (#TPD). @ACSBioMed pubs.acs.org/doi/10.1021/ac…

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Marcus Hartmann@HartmannLab·24 Şub

Check out our work on regulating #Salmonella virulence @biorxivpreprint! Great job by Joe, Wieland, Thales, @BangeBalcony, @atposo & @samuwag: HilE represses the activity of HilD via a mechanism distinct from that of intestinal long-chain fatty acids. biorxiv.org/content/10.110…

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Khaled A. Selim@Selim_Khaled_·18 Şub

After long time in oven, happy to share w/ @HartmannLab @PNASNews our work #Cyanobacteria #Carbon #Sensor SbtB possesses atypical #Redox regulated #Apyrase (hydrolysing ATP/ADP) to control HCO3 transport Generous fund by @uni_tue_exstra @CoE_CMFI @MPI_Bio pnas.org/doi/10.1073/pn…

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Marcus Hartmann@HartmannLab·25 Oca

Happy to share the missing link between the action of #IMiDs & #CELMoDs and the natural #CRBN degron @BBRCME: Neo-substrates mimic every single H-bond of cyclic imide #degron recognition, inevitably inheriting sequence-independence of natural #degrons 👇 sciencedirect.com/science/articl…

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Marcus Hartmann@HartmannLab·22 Oca

@KylieAllenVT @FEBS_Letters Congrats, very nice story!

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Kylie Allen@KylieAllenVT·21 Oca

Check out our new paper in @FEBS_Letters! febs.onlinelibrary.wiley.com/doi/full/10.10…

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Christian Steinebach@c_steinebach·19 Oca

🧪Happy to share our work on three-branched CRBN ligands for MG and #PROTACs design. A multicomponent reaction as synthetic entry🤯Nice work by my PhD student Robert and @KroenkeLab @HartmannLab at the interface between Chemistry & Biology. #OpenAccess rsc.li/3wfEtJg

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Christian Steinebach@c_steinebach·24 Ara

🚨PhD alert just before Xmas 🎅 My lab offers a PhD position within the @GRK2873 funded by @dfg_public The project is devoted to #PROTACs and E3 ligand #chemistry #lifesciences For more information visit our website 👇👇 and apply! Please help & retweet!

GRK2873@grk2873

📢Are you looking for a PhD project or a postdoc position in the field of innovative methods and new modalities in #MedChem? We are now hiring 12 talented PhD students and 1 Postdoc for the new RTG 2873. Pick your project(s) and learn how to apply here: grk2873.uni-bonn.de/en

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Guillaume Laconde@Glaconde34·9 Ara

Synthesis of novel glutarimide ligands for the E3 ligase substrate receptor Cereblon (CRBN): Investigation of their binding mode and antiproliferative effects against myeloma cell lines sciencedirect.com/science/articl…

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Marcus Hartmann@HartmannLab·2 Ara

🥳🥳 Congrats, great job! 🥳🥳 Fantastic PhD defense by Joe this week, showcasing great results from your collaborative salmonella anti-virulence project with @samuwag @atposo @BronstrupLab! #Salmonella, beware of Joe! @phd_reps_MPI_DB

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发现

@PAW_Germany @PNASNews @growkudos @uni_tue_exstra @CoE_CMFI @alessiociulli @IzidorSosic @UniBonn