Krönke Lab

Protein-Genomics Myeloma Session #ASH24 chaired by Dr Paola Neri ⁦@FrancescoMaura4⁩ @kronkelab ⁦@fabianaperna⁩

Early View | Haematologica haematologica.org/article/view/h… Finally first results from our Phase 1 TCR study targeting MAGE-A1 in myeloma! Hopefully more to come in advanced solid tumors where need for innovative (cellular) therapies is still HUGE.

Teclistamab-Induced Remission in Refractory Systemic Lupus Erythematosus | New England Journal of Medicine nejm.org/doi/full/10.10…

Wonderful collaboration with Philipp Mertins, Stefan Knop, DSMM study group, and many others!

Happy to share that our #proteogenomic study of multiple myeloma led by Evelyn Ramberger is out now @NatureCancer rdcu.be/dL9wZ @MDC_Berlin @ChariteBerlin @berlinnovation

Our multiomics analysis including deep TMT-based (phospho)proteomics, RNA sequencing, and nanopore DNA sequencing of 138 primary multiple myeloma samples reveals new insights into disease biology and treatment opportunities

We had a record number of (high quality) abstracts for this year’s Mol Hem workshop @EHA_Hematology annual meeting. Check out the 12 selected talks ehaweb.org/congress/eha20…

Our paper on using heteroPROTACs to induce potent pan-IAP degradation is finally out! Check out our results from the IAP vs VHL&CRBN battle 🥊—> bit.ly/3K0aMCp Very happy about this great collaboration with our established team 😁@IzidorSosic @c_steinebach, @KroenkeLab

Excited to announce that our lab has been awarded an #ERC_StG grant to study immunological interactions in leukemias. Thanks to our team members, collaborators, friends and family for the constant support! @berlinnovation @MDC_Berlin @ChariteBerlin @ERC_Research

It's the E3 ligase Smac-down!🥊VHL and CRBN face IAPs head to head.🥊Who shall prevail? Welp, our preprint title gives it out, IAPs get totally K.O.'d. bit.ly/3QHGGEV. A great collaboration from @c_steinebach, @KroenkeLab, @AlesaBricelj and @IzidorSosic #TPD #PROTACs

@rschneiderlab @adamssperling @tarekmd91 @IreneGhobrial @TheBoettcherLab @PLMcCarthyMD @SykesLabMGH @c_j_gibson Congrats Adam, great work!

@adamssperling @KroenkeLab @tarekmd91 @IreneGhobrial @TheBoettcherLab @PLMcCarthyMD @SykesLabMGH @c_j_gibson I hope we will be able to catch up again this year!

Excited that our new paper is now online @BloodJournal. ashpublications.org/blood/article/… This has been a wonderful collaborative effort between our teams @DFCINews and @MDAndersonNews. #mmsm #leusm

Very excited to share our latest work, now published online first in @CD_AACR! Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts aacrjournals.org/cancerdiscover…

We employed the BTB domain of transcription factor BCL6 as small-molecule-controlled reversible oligomerization switch. Led by @lena_nitsch and my first corresponding author manuscript @CellRepMethods 1/16 cell.com/cell-reports-m…

Our latest TPD research now online as a preprint: Expanding the PROTAC Toolbox: Targeted Degradation of the Deubiquitinase USP7 in Cancer | ChemRxiv. lmy.de/VQrs8 #chemtwitter @KroenkeLab @IzidorSosic

Glad to see our work on #SARSCoV2 inhibiting semisynthetic compounds on the front cover of @ChemMedChem !!! Thanks 🙏 to collaborators @UFZ_de @Mueller_AG @UniBonn @IzidorSosic @UniklinikBonn #chemtwitter Article is #OpenAccess (DEAL). Link to our work 👉 tinyurl.com/4s8k9fzk

Happy to announce our new work identifying cdk6 in lenalidomide resistant multiple myeloma published in @NatureComms rdcu.be/cHA4R great collaboration @ChariteBerlin @MDC_Berlin

First $ARVN, then $KYMR, now $NRIX PROTACS work!!! Not sure this class gets the credit it deserves for its huge potential. Still early days and chemistry isn't trivial but the potential here is huge: The ability to degrade every protein with an oral small molecule...

Check our new paper Comprehensive CRISPR-Cas9 screens identify genetic determinants of drug responsiveness in multiple myeloma | Blood Advances | American Society of Hematology ashpublications.org/bloodadvances/…

@c_steinebach @IzidorSosic 👍👍👍

The last chimera that was evaluated during my PhD program! Successfully defended my thesis today! Off to new adventures, ofc in the TPD field! Thanks to all friends, family and collaborators for your support!!! Special thanks to ⁦@KroenkeLab⁩ ⁦@IzidorSosic⁩