Jan Mathony

@Leti_RM_96 Thanks leti :)

@JanMathony @naturemethods That's awesome! Congratulations!!! 💃👏

Publication alert: Our paper on domain insertion predictions in proteins is now out in @naturemethods in its final form: rdcu.be/ey7w3 Also check out the nice perspective by Noah Holzleitner and Julian Grünewald: nature.com/articles/s4159…

ProDomino is a machine learning-based method that predicts domain insertion sites and helps guide the engineering of functional multi-domain proteins. nature.com/articles/s4159…

I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!

Excited to share my main PhD work is finally out! 🥳 We built a phage-assisted evolution platform to evolve allosteric protein switches (POGO-PANCE) and introduce cumulative, targeted mutations/Indels (RAMPhaGE)! See how we evolved strong, light-switchable AraC variants:

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share! youtube.com/watch?v=8YhJM6…

Modular Engineering of Thermo-Responsive Allosteric Proteins biorxiv.org/content/10.110… #biorxiv_synbio

Huge congrats to all authors, especially to co-first authors Kira Hoffmann and Ann-Sophie Kroell, who did an outstanding job!

In line with recent work by Bugaj and colleagues, who pioneered the thermal programming of protein localization and cell signaling using BcLOV4 (nature.com/articles/s41...), our result highlight LOV domains as versatile thermoreceptors.

New paper alert! We introduce the modular allosteric thermo-control of protein activity. biorxiv.org/content/10.110…

In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️ @RachelSilvers11 @CGM_MGH @MGH_RI @MassGeneralNews @harvardmed nature.com/articles/s4158…

@CeMM_News @BockLab It was a pleasure to meet all of you and discuss science! Many thanks again for the invitation.

Many thanks to @JanMathony for presenting his intriguing research on allosteric protein switches, and how to design them using ML-based prediction of insertion sites for domains like the photoreceptor LOV2 - and thank you to @BockLab for hosting this impromptu seminar at #CeMM!👏

We are looking for a new PhD student to join our lab of Neuroepigenetics at EPFL! Interested in deciphering the epigenetic mechanisms of memory formation, storage and change?🧠🧬Check out the specifics here: graefflab.epfl.ch

We have an exciting new PhD opportunity! If you are fascinated by proteins and their dynamics and want to engineer them to develop new molecular tools: apply now! We are a young and dynamic team combining state of the art laboratory and bioinformatics approaches. Please share.

@RodriSenovilla @PhyloBrain @MargaridaMCM @AinaCastellanos @jlferran @AchucarroGlia @kaessmannlab Congrats Rodrigo!! That's great news :)

Last Friday, I became a PhD! 💐 I could not be more thankful to my supervisor @PhyloBrain, the thesis committee @MargaridaMCM @AinaCastellanos @jlferran and everyone who made possible this journey (colleagues @AchucarroGlia and collaborators @kaessmannlab) 🥰

So excited to announce that our study on the development and evolution of pallial cell types and structures in birds led by @BassiZaremba is now out in @ScienceMagazine! science.org/doi/10.1126/sc… PS: this is our last post here – please follow us to where the sky is blue!

Conducted by @RuedaEneritz, we have seen that pallial neurons are generated in different regions and stages of the embryonic brain🐣🦎🐀: pallial neurons and circuits have evolved separately. Evolutionary CONVERGENCE of neurons and circuits! shorturl.at/PlWGR