gerald pao

New preprint from the lab! How do tissue shapes influence cell fate decisions? By manipulating brain organoid geometry, we show that lumen rounding directs apical progenitor division mode and promotes the emergence of basal progenitors. biorxiv.org/content/10.648… 1/

@deepfates @DanielleFong This was the same year as Rummelharts Back propagation paper that made it possible. This was much better than Boltzmann machines nature.com/articles/32353…

@deepfates @DanielleFong NetTalk the first neural network that could convert text into speech was from 1986 papers.cnl.salk.edu/PDFs/NETtalk_%…

How did Dan Simmons know about AI weights in 1989? Was this a term of art already

Evo 2, our fully open-source biological foundation model trained on trillions of DNA tokens spanning the entire tree of life, is out in @Nature today We & the scientific community have done a lot with this @arcinstitute @nvidia model in the last year! 🧵👇

@seemaychou Thank you so much

@PLURplus enjoyed reading this

Our new preprint demonstrates experimentally the existence of causation without correlation at transcriptional network nodes where information integration occurs within biological networks and on the surface of low dimensional manifolds biorxiv.org/content/10.648…

@jordanschochet Check out the recent work by Doyne Farmer, you might enjoy his relatively recent book.

@PLURplus Cool paper. Ideas like this in non finance fields are why it’s time to revisit nearly all legacy 1960s Econ assumptions, such as “joint hypothesis problem” Bio translation: in econ people still use lessons from pre germ theory (tulip mania), and efficient market (pre DNA)

During Thanksgiving break last year, our AI co-scientist team @GoogleDeepMind @GoogleResearch - @Mysiak @alan_karthi met Prof @jrpenades @CostaT_Lab of @ImperialCollege. They were nearing a breakthrough on how bacteria share resistance genes and proposed a test for our AI co-scientist: pose their exact research question to the system and see what it found. Today in @CellCellPress, we share the results. Paper link - cell.com/cell/fulltext/…

resist using RAM

Last month at the Mathematical foundations of biological organization meeting at Les Diablerets 🇨🇭got to hang out with some dynamical systems legends and ran into some unexpected old friends at the meeting Nextdoor.

The “Manifolds in Nature” meeting this year was held in Geneva, Switzerland 🇨🇭 on May 11-16 organized by Stanislav Smirnov and myself. This edition was more focused on the mathematics. It intersected with the Georges de Rham lectures by two of the meeting participants.

To students who have been impacted by the current uncertainty in the U.S. that have been already accepted or are currently in U.S. graduate programs we are now accepting applications for a special admissions cycle. Deadline June 15th. oist.jp/admissions/spe…

@AdrianoAguzzi Interactive graphs on something like the 3D version of plotly

The Norwegian Academy of Science and Letters has decided to award the Abel Prize 2025 to professor Masaki Kashiwara. Kashiwara-san is the first Japanese mathematician to receive the Abel Prize. #Abelprize #Abelprize2025 #mathematics #science

Very much agreed

In a few weeks we will hold a meeting to explore the possibility of existence of quantum computing algorithms inspired from Algorithms in nature or AI or problems that quantum can solve in AI or neuroscience with the current medium precision of quantum. groups.oist.jp/qed/event/%E3%…

@AdrianoAguzzi Sorry to hear Adriano. Hope everything goes well and you feel better soon. If you are recovered and feel up for it, I will stop by on trips to Switzerland in March and May. Wishing you a speedy recovery

@roninhahn The idea resonates with my general approach. Thank you. Will take a closer look

A low dimensional manifold of gene expression relationships from RNA trajectories. #RNAseq #Biology #DataScience #nonlinearDynamics #math #complexity #Datavisualization

New paper “Possible Shift in Controls of the Tropical Pacific Surface Warming Pattern” by Watanabe et al. - @Nature nature.com/articles/s4158…

Ocean warming pattern: most of ocean areas show a warming trend.