Tiago Costa

Great to see this feature in Nature Medicine! When our team at @GoogleDeepMind @GoogleResearch introduced the AI Co-Scientist in our February 2025 preprint, we knew we were on the cusp of a fundamental shift in how research is done. To see the work inspire the community and catalyze a global movement to accelerate scientific discovery in such a short time is incredibly thrilling. Huge shoutout to our amazing collaborators Prof @jrpenades @CostaT_Lab of @ImperialCollege and Prof Gary Peltz at @StanfordMed Medicine who took the leap with us and pushed the boundaries to validate this new paradigm of human-AI collaboration in science. So much momentum and so much more to come, rather soon 😊 Link: rdcu.be/e8xmk With @Mysiak @alan_karthi and so many incredible Google teammates behind AI Co-Scientist.

Please RT:📢We are hiring a Post-Doc in Structural Biology to join our multidisciplinary team. Project: study molecular mechanisms of horizontal gene transfer using cryo-EM and integrative structural biology. Apply: shorturl.at/ecrVL #StructuralBiology #CryoEM #Postdoc

🚨 PhD Opportunity in my lab🚨 Harnessing Phage Satellites for Next-Generation Biological Crop Protection 🗓 Deadline: 12 Jan 🔗 Apply: tinyurl.com/425x8ahj 🔗 Project : tinyurl.com/22uanm86 Interested in Structural Microbiology, Phage Biology & SynBio - Apply Now!

The multi-agent AI co-scientist system (employing Generation, Reflection, Ranking and Evolution agents) has three key attributes: simulation of scientific debate between pairwise combinations of generated hypotheses, test-time compute scaling to improve outputs, and an internal auto-evaluation metric. Research collaboration with academic partners confirms its potential for drug repurposing for Acute Myeloid Leukemia, and for insights related to Liver Fibrosis.

Blog on AI co-scientist research.google/blog/accelerat… Paper on AI co-scientist and follow up papers: Towards an AI co-scientist: arxiv.org/abs/2502.18864 On uncovering a mechanism of gene transfer: cell.com/cell/fulltext/… AI-Assisted Drug Repurposing for Human Liver Fibrosis: advanced.onlinelibrary.wiley.com/doi/pdf/10.100…

In a panel with @CostaT_Lab, our partner from Imperial College London, and with @vivnat we’ve discussed how Google’s co-scientist demonstrated AI’s core reasoning capability by performing novel reasoning on lab’s unpublished on a complex antimicrobial resistance mechanism, Picture from the panel

Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see imperial.ac.uk/jobs/search-jo…

The AI co-scientist from @GoogleAI is proving itself more than a novelty. In two bio studies, it generated promising, testable hypotheses that could have taken years of lab work to uncover. With insights from @vivnat, @KyleWSwanson, and other experts. spectrum.ieee.org/ai-co-scientis…

When resistance genes jump between species of bacteria, they spread far beyond their original hosts. New @imperialcollege research explains how these "pirate" phages fuel antimicrobial resistance: genengnews.com/topics/infecti…

Now online! Chimeric infective particles expand species boundaries in phage-inducible chromosomal island mobilization dlvr.it/TN0X9B

@jrpenades @CostaT_Lab had a paper in peer review marking a pivotal milestone from years of work, describing a novel mechanism for gene transfer through 'microbial piracy'. Their work revealed how mobile genetic elements "cf-PICIs" hijack the tails from viruses to create hybrid particles, allowing them to inject DNA -which can carry genes for antibiotic resistance - into a wide range of bacteria, explaining how these dangerous traits spread so efficiently. This was the result of years of meticulous experimental work but the breakthrough insight had never been made public.

It's an extraordinary privilege to work on AI systems with such a profound potential to super-charge science, not by replacing human insight, but by accelerating it. The true impact comes from collaborating with experts like @jrpenades @CostaT_Lab to tackle biomedicine's great challenges. We're delighted to share authorship on this paper in Cell and excited for many more upcoming discoveries from the improving AI coscientist system. Watch this space!

Now online! AI mirrors experimental science to uncover a mechanism of gene transfer crucial to bacterial evolution dlvr.it/TN0F0H

Our partners at @Imperial College London used @GoogleDeepMind's AI co-scientist to focus on the most promising directions to investigate antibiotic resistance; performing years of work in days. This is great example on how AI will super-charge Science for the benefit of humanity.

Imperial scientists found how ‘pirate phages’ hijack viruses to spread traits like antibiotic resistance 🏴‍☠️ Tested using @GoogleDeepMind’s AI ‘co-scientist’ in a project coordinated by the @FlemingCentre, the work could help in the fight against AMR 👇 imperial.ac.uk/news/268213/mi…

Did you know viruses can hijack other viruses? 😲🦠 Imperial researchers found that ‘pirate phages’ swap parts to sneak into bacteria — a discovery that could be harnessed to tackle #AntibioticResistance. @ImperialInfect #AMR imperial.ac.uk/news/268213/mi…

During Thanksgiving break last year, our AI co-scientist team @GoogleDeepMind @GoogleResearch - @Mysiak @alan_karthi met Prof @jrpenades @CostaT_Lab of @ImperialCollege. They were nearing a breakthrough on how bacteria share resistance genes and proposed a test for our AI co-scientist: pose their exact research question to the system and see what it found. Today in @CellCellPress, we share the results. Paper link - cell.com/cell/fulltext/…

Our second paper with @CostaT_Lab and @GoogleDeepMind reports our experience with Google’s co-scientist: remarkably, the AI independently recapitulated our experimental discovery on cf-PICIs, showcasing AI’s potential to accelerate biology.  cell.com/cell/fulltext/…

Thrilled to share our two latest papers with the @CostaT_Lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species.  @imperialcollege @CBRB_Imperial cell.com/cell/fulltext/…