Patrick English

GLP-1RA cardiovascular protection is duration dependent. In >330k people with T2D: 🫀 Risk reduction strongest with continuous 3-year use (IRR 0.82) ⏳ Short use (<1.5 yrs) → little CV benefit ⛔ Interruptions or discontinuation → progressively ↑ MACE risk Consistency matters. Long-term treatment drives cardiovascular protection. pmc.ncbi.nlm.nih.gov/articles/PMC13…

@RenaudB31 I was absolutely ecstatic with Wout’s success but Christophe Laporte was incredible on Sunday-not enough said about his performance and what he delivered. I hope he too gets his time

#ParisRoubaix 🪨 / La satisfaction de 🇫🇷 Christophe Laporte (TVL), équipier modèle du vainqueur de Paris-Roubaix 🇧🇪 Wout Van Aert (TVL). 💬 "J'étais touché. Wout est un ami. Je suis venu dans l'équipe pour l'aider à atteindre cet objectif-là, Paris-Roubaix, une course dont il rêvait. Il était très fort aujourd'hui, il le mérite mille fois. Wout m'a beaucoup aidé depuis que je suis arrivé dans cette équipe, j'ai beaucoup appris de lui et de sa mentalité." 💬 "C'est ce qui fait la beauté de son histoire. Il a vécu tellement de péripéties dans sa carrière, des hauts bien sûr, mais aussi beaucoup de bas. C'est pour ça aussi que je suis tellement content pour lui. Il n'y a pas un coureur qui le mérite plus que lui." 📎 Lien de l'article : lequipe.fr/Cyclisme-sur-r… 📷 E. Garnier 🎙 L'Équipe

@daniellloyd1 If you go 20 minutes at 6.6% how many more efforts do you have left in you for this last 80k?

Just a few years ago, it was too early to go this hard. However, in this modern day you have to anticipate. #RVV26

Swimming With the Omnipod 5 Automated Insulin Delivery System by @5Dess and Stanford team- goo.gl/scholar/n6kzbz #ScholarAlerts

The use of SGLT2is does not negatively impact amputation rate or healing rate of diabetic foot ulcers. One-year mortality lower in people treated with an SGLT2i. diabetesjournals.org/care/article/4…

#Tubeless automated insulin delivery versus multiple daily injections in children and adults with type 1 #diabetes with elevated HbA1c (RADIANT): a multicentre, international, parallel-group, open-label, randomised, controlled trial thelancet.com/journals/landi… #T1D #CGM #AID

It took 9 years and 3 billion miles to get this shot. The icy mountains of Pluto.

Beyond Euglycemia: Case Studies Using #CGM in Elite Athletes Without Diabetes During Record Athletic Events mdpi.com/3757720 #mdpisensors via @Sensors_MDPI

Obesity isn’t just a metabolic risk. It’s an infection risk. Evidence suggests ~1 in 10 infection-related deaths worldwide may be attributable to obesity. Obesity increases hospitalisations and mortality across many pathogens and populations. #Obesity #InfectionRisk #PublicHealth sciencedirect.com/science/articl… @TheLancet

@DrRobAndrews Great work-love that 406 variables become 3 with comparable predictive power

Our glucosego paper is out - eur03.safelinks.protection.outlook.com/?url=https%3A%…

The use of SGLT2is does not negatively impact the 1-year amputation rate or healing rate of diabetic foot ulcers One-year mortality was lower in patients treated with an SGLT2i. Important study for clinical practice diabetesjournals.org/care/article/d…

Could managing type 1 diabetes take up less brain power? CLEAR studies explored fully closed-loop insulin delivery. No carb counting, no meal bolusing — in adults and teens. More time in range. Better sleep. Easier mealtimes. #T1D #FullyClosedLoop #DiabetesTech

@Doctors_net_uk Some areas have not sorted local funding yet for any prescriptions so lots to do here

GPs will be incentivised to offer weight-loss drugs to 'increase access' #NHS #GPs #doctors doctors.net.uk/news/gps-will-…

RADIANT RCT of OP5 HCL published today - thank you to all the investigators, teams and participants involved! @drpratikc @LalanthaL @mayng888 @DTN_UK @ABCDiab

@MCRiddell1 Is<70 really hypoglycaemia in those without diabetes and with intact physiology?

Hard to believe that so much #hypoglycemia ocurrs with prolonged #fasting in people without #diabetes

Ever wonder how prolonged #fasting might impact your blood (sugar) #glucose? We did... And we found out with the use of #CGM... See journals.sagepub.com/doi/10.1177/19…

Creatine can increase muscle mass, strength and power when combined with resistance training, but what about endurance performance? This blog explores emerging evidence on whether creatine can support endurance athletes in key race moments. Click here: mysportscience.com/post/does-crea…

⚖️🧠 Obesity + type 2 diabetes: Brain stimulation vs drugs? 📊 12-month retrospective comparative study 💉 Semaglutide (0.5 mg/week): −5.7 kg 🧠 Transcranial Magnetic Stimulation (non-invasive brain stimulation): −8.2 kg 💊 SGLT2i: −2.0 kg(with weight regain after 6 months) 🔑 Brain stimulation achieved weight loss comparable medications ? a promising emerging option in obesity care. Longer term trials with safety outcomes required #Obesity #Type2Diabetes #GLP1 #rTMS #weightloss onlinelibrary.wiley.com/doi/full/10.10…

Nice new study on a comparison between ultra rapid vs rapid acting insulin analogs and #exercise in #T1D- goo.gl/scholar/3mTXab #ScholarAlerts

For about a decade, I’ve been showing these two slides at conferences. Two hunter-gatherer populations (Hadza and Tsimane), likely the closest living humans to our Paleolithic ancestors. Diet: • 65–70% carbohydrates • 15-20% protein • 10–15% fat • ~13% lower daily caloric intake than the US population Daily movement: • 115–135 minutes per day • 6–12 km of walking Health outcomes: • Obesity: ~2% • Type 2 diabetes: ~1% • Cardiovascular disease: among the lowest ever observed This is not a low-carbohydrate population. The difference is metabolic fitness. When mitochondria are continuously stimulated by daily movement, carbohydrates can be oxidized (burnt). When movement disappears, fuel oxidation fails and metabolic disease emerges. The debate should not be low-carb vs high-carb. That debate has failed to solve obesity or type 2 diabetes for decades. The real question is: Can your mitochondria still do their job? #MitochondrialFunction #MetabolicFitness #MetabolicFlexibility #PhysicalActivity