Robert Spitale
4.1K posts


Perplexity just quietly dropped a 42-page internal guide on how they actually use AI at work.
What I found most useful:
→ How they automate the small stuff. Email, meeting prep, research (all done by AI)
→ Using AI to amplify your curiosity, not replace it.
→ Their prompting playbook is simple, practical, and genuinely good.
Comment “AI” and I’ll send it to you for free.


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@stoolpresidente Yes @stoolpresidente the next worst thing is that we don’t beat Mahomes to the first SB victory. That road needs to be traversed.
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@srikosuri They’re also difficult to go off of and maintain weight loss, food noise (+ whatever other compulsive behavior) comes back after washout. I do think we’ll start to see tiered therapies used clinically e.g. Tirzepatide for x months until goal achieved and switch to something else.
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THE OINC IS HERE! New tour-de-force with @JMTali, years in the making! Direct sequencing of chemical modifications on RNA to measure RNA localization transcriptome-wide. Read about OINC-seq here:
biorxiv.org/content/10.110…
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Excited to see this happening. Go proteasome stimulation!!! linkedin.com/posts/felecian…
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BIGLY congratulations to @raflynn5 #glycoRNA!
@NIH_CommonFund's Transformative Research Award! #NIHHighRisk hscrb.harvard.edu/news/flynn-nih…
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@GrumpyReviewer2 @JMTali this isn’t one we worked on together, right? Right? Right!!?!!!???!?
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Very excited to share our latest preprint, led by rockstar post-doc @i_borovska. Our humble attempt to begin exploring #RNA secondary structure ensembles in a living cell (biorxiv.org/content/10.110…) (1/n)
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