置顶推文

Very pleased to share our latest, out today in @CellCellPress.
cell.com/cell/fulltext/…
We looked at the role of prefrontal neurons in a rodent model of cross-sensory attention shifting, and get this...
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@cshperspectives @drugmonkeyblog @WiringTheBrain I don’t think there’s anything special about the candidate gene era - strong hypotheses + many cryptic degrees of freedom + publication bias led to high false positive rates, like much of current biomedicine. The only difference is that there was a reckoning, due to GWAS.

This paper is the outcome of a long and arduous journey toward an optogenetic dissection of local circuit connectivity in the prefrontal cortex. We combined opsin engineering, 2-photon imaging, new analysis tools and hundreds of hours of complex experiments...