Avraham Ashkenazi

Our paper published online in @Brain1878. We identify a cancer-associated #ubiquitin enzyme as a potential therapeutic target in #Huntington's disease. @TAUMedFaculty @of_sagol academic.oup.com/brain/article/…

Elegant study on that fit the unconventional secretion mode of TMEM16F: Lipid scrambling via TMEM16F mediates the formation and release of extracellular vesicles | Molecular Biology of the Cell molbiolcell.org/doi/10.1091/mb…

Mitochondrial dynamics in neurodevelopment and neurodevelopmental disorders — a Review by Carissa L. Sirois, Jiyoun Lee, Audrey L. Chambers & Xinyu Zhao nature.com/articles/s4158…

@NatRevMCB Very informative analysis for studying development and neurodevelopmental diseases involving the P-ANS

New Online! Neural crest gene regulatory networks as drivers of development, diversification and disease dlvr.it/TRHwmR

The most sensitive green and red #norepinephrine #sensors engineered to date are out in @naturemethods! Deeply grateful to all our funders and contributors who made this work possible. A true team effort. @ERC_Research @snsf_ch @UZH_en @UZH_IPT doi.org/10.1038/s41592…

Stochastic misfolding drives the emergence of distinct α-synuclein strains: Neuron cell.com/neuron/fulltex…

Elegant work. Congratulations to Julie and team. #Parkinson's disease #alpha-synuclein secretion

Check our new work @NatRevMCB . It was fun working with Gali Prag on this piece. Stay tuned for more research on this exciting topic from our lab. Thanks 🙏 to referee and editor for the feedback @of_sagol @TelAvivUni

PROTAC-Mediated Degradation of mHTT Aggregates Attenuates Neurotoxicity in Cellular and R6/2 Mouse Models of Huntington’s Disease | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Stay tuned for more research from our lab on this exciting topic!

Free access link to the paper: rdcu.be/e4U3Y

Our article commentary is out in @NatRevMCB. 🎉 Together with Gali Prag, we discuss the emerging functions of the #ubiquitin enzyme UBA6 in health and disease. @of_sagol @taumed nature.com/articles/s4158…

We are excited to announce that the Parkinson’s Foundation and @ACSMNews, the world’s largest sports medicine and exercise science organization, have announced updated recommendations to provide safe and effective guidance on exercise for people with Parkinson’s disease. The updated exercise recommendations were published following extensive review from subject matter experts, as well as members of the PD community who actively use the recommendations. Read more: Parkinson.org/about-us/news/…

Congratulations Edward and team :beautiful work.

The consequences of this mechanism for prion-like aggregate spreading need to be explored. Congratulations! Nice.

New online! Towards biomarker-based diagnosis of Parkinson disease dlvr.it/TQxnwd

Important resource

Protective ApoE variants support neuronal function by effluxing oxidized phospholipids: Neuron cell.com/neuron/fulltex…

@JCellBiol Congratulations Chen and Arad

Soffer, Bhosale, Niessen, Luxenburg, Rübsam et al. identify #spectrin as a central component of epithelial cortical #actomyosin networks to control cortex mechanics and signaling. hubs.la/Q042SRmv0 #CellSignaling #Cytoskeleton #Development

Articles in our latest collection focus on the roles of ATG9 and LC3 interacting regions, plus mechanisms of selective #autophagy involving Rab GTPases, #mitophagy, and #pexophagy. 👉 hubs.la/Q040Nfh60

Mecca et al. investigate the role of muscle stem cells in SMA and show that their depletion disrupts neuromuscular junctions and leads to motor neuron loss in the spinal cord. They conclude that muscle stem cells represent potential therapeutic targets. shorturl.at/vIwEU