Tai Chaiamarit

In @natrevbioeng, Core Investigator @FelixHorns and colleagues outline how engineered living cells could deliver mRNA to places lipid nanoparticles and viral vectors can't reach, homing to disease sites and activating only when they detect the right signals.

Generating exosome subtypes: diverse membrane origins and mergers dlvr.it/TS1HNG

Enjoy!! researchgate.net/profile/Arumug…

Graduate students increasingly use artificial-intelligence tools to draft, code and search — but many fear it could erode the very skills a doctorate is meant to build go.nature.com/4bmCOaa

Potential of mitochondrial transfer to prevent or treat Parkinson' s disease, in mouse and monkey models @CellCellPress cell.com/cell/fulltext/…

Mitochondria acidify lysosomes through membrane contacts @uofcincy @SunLabUCin sciencedirect.com/science/articl…

In a 2025 @SciSignal Review, researchers discussed an emerging body of research on the metabolic effects of sleep loss, which disrupts the natural balance of energy within neurons. ⁠ ⁠ The authors highlighted how the loss of sleep forces neurons to shunt resources to cell survival pathways, at the expense of more long-term, energy-demanding processes such as cognition and memory formation.⁠ ⁠ Learn more on #WorldSleepDay: scim.ag/42opuwh

Angelina Kim, Spencer Freeman @spencerSK1 et al. @SickKidsNews describe a mechanism for #lysosomes to sense and respond to acute increases in their #membrane tension by relieving hydrostatic pressure via the outward transport of major osmoticants. hubs.la/Q046lYcr0

Science Has a Major Fraud Problem 'For decades, scientists were above reproach. Not any more. @opinion_joe investigates the murky world of fraudulent research, and the sleuths exposing dishonest science' @TheFP thefp.com/p/science-has-…

🚨BREAKING: MIT hooked people up to brain scanners while they used ChatGPT. What they found should concern every single person reading this. ChatGPT users showed 55% weaker brain connectivity than people who didn't use it. Not after years. After just four months. Here's how they tested it. 54 people were split into three groups: one used ChatGPT to write essays, one used Google, and one used nothing but their own brain. They wore EEG monitors that tracked their brain activity in real time across four sessions over four months. The brain-only group built the strongest, most widespread neural networks. Google users were in the middle. ChatGPT users had the weakest brains in the room. Every time. Then the memory test hit. Participants were asked to recall what they'd just written minutes earlier. 83% of ChatGPT users couldn't quote a single line from their own essay. They wrote it. They couldn't remember it. The words passed through them like they were never there. It gets worse. In the final session, ChatGPT users were told to write without AI. Their brains were measurably weaker than people who never used AI at all. 78% still couldn't recall their own writing. The damage didn't go away when the tool was removed. Meanwhile, brain-only users who tried ChatGPT for the first time? Their brains lit up. They wrote better prompts. They retained more. Their brains were already strong enough to use AI as a tool instead of a crutch. The researchers also found that every ChatGPT essay on the same topic looked almost identical. More facts, more dates, more names. But less original thinking. Everyone using ChatGPT produced the same generic output while believing it was their own. MIT gave this a name: cognitive debt. Like financial debt, you borrow convenience now and pay with your thinking ability later. Except there's no way to pay it back. The question isn't whether ChatGPT is useful. It's whether the price is your ability to think without it.

The 3 hardest things to learn as a scientist: 1. Trust the data.. especially when it’s not what you expected, 2. Trust the data.. allowing it to change your direction, 3. Trust the data.. but not too much: test with new data at every turn.

Enjoy!!! frontiersin.org/journals/medic…

Generates scientific diagrams from text or papers github.com/ResearAI/AutoF…

An old favorite for this #FluorescenceFriday. This "rose" is actually a kidney glomerulus (red, podocytes) and an axon reaching towards it (green).

AI is cool and all... but a new paper in @ScienceMagazine kind of figured out the origin of life? The paper reports the discovery of a simple 45-nucleotide RNA molecule that can perfectly copy itself.

In the latest issue! Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder dlvr.it/TQrq4M

A Sticky Dance Between a Cell and a Neuron. #neuroscience #science #mysterious #HiddenWorld #cell #FluorescenceFriday ➡️A Schwann cell precursor interacting with sensory axons 🔬🧫

Under the hood, a cell is constantly in motion. How much energy does it cost to keep everything moving? Striking bolts of lights are polymerizing pieces of the cytoskeleton—microtubules. Video by Andy Moore.

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender dlvr.it/TQl1ZZ

ER remodelling is a feature of ageing and depends on ER-phagy nature.com/articles/s4155…