Tamara Lotan, MD

50 posts

Tamara Lotan, MD

Tamara Lotan, MD

@LotanLab

Molecular pathologist with focus on prostate cancer. Johns Hopkins University.

انضم Mayıs 2019
182 يتبع482 المتابعون
Tamara Lotan, MD أُعيد تغريده
Kaushal Asrani
Kaushal Asrani@AsraniKaushal·
Excited to finally share our latest study on #TranslocationRCC #PEComas @NatureComms! We generated the first ever, murine transgenic kidney tumor models of SFPQ-TFE3 - the most common MiT/TFE gene fusion implicated in both, tRCC and PEComas (Perivascular Epitheloid neoplasms). We describe a novel role for this fusion in regulating #mTORC1-driven lineage plasticity, with transcriptional downregulation of critical nephric lineage transcription factors like PAX8, that perfectly recapitulate human renal PEComas. Additionally, we nominate the lysosomal V-ATPase complex as a central regulator of mTORC1 activity in tRCC, and a target-rich environment for therapeutic intervention in this deadly disease. Grateful to all the co-authors, collaborators, reviewers, editors and funding sources who made this study possible! @adriannaamendes @LotanLab @eddieimada @MasayaBaba2 @terry_watnickmd @WMarstonLinehan @PeterArgani @yasserged @rmelias2 @nirmishsingla @allaf_mo @Joeyswings @KidneyCancer @kidneycan @CDMRP nature.com/articles/s4146…
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Tamara Lotan, MD أُعيد تغريده
Swati Bhardwaj, MD
Swati Bhardwaj, MD@DrSwatiBhardwaj·
Come stop by our poster (No. 179) on the Association of Histologic Subtype, Genomic Driver Mutation, and mTORC1 Biomarker Expression in TSC1/2/MTOR-Altered Tumors! Privileged to get the opportunity to work with Dr. Lotan! @LotanLab #GUPath @TheUSCAP #USCAP2025
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Tamara Lotan, MD أُعيد تغريده
Ralph Hruban
Ralph Hruban@RalphHruban·
Congratulations Johns Hopkins resident Eric Young- winner of the 2025 abstract award from the Pancreatobiliary Society at the 2025 USCAP meetings!
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Tamara Lotan, MD أُعيد تغريده
Gladell Paner, MD
Gladell Paner, MD@GladellPaner·
Joint GUPS and ISUP Expert Consultation on Intraductal Carcinoma of the #Prostate. Boston, MA USA March 22, 2025. Thank you Dr. Rajal Shah @rajalbshah, Dr. Glen Kristiansen, @GU_Path_Society and @IntSocUropath! It’s a great moment in our field. So proud of #GUPath! 🙏🏻
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Tamara Lotan, MD أُعيد تغريده
Samson W. Fine, MD
Samson W. Fine, MD@rovingatuscap·
GUPS @GU_Path_Society Poster Walks return for #USCAP2025 featuring an outstanding line-up of international experts in #gupath Especially geared to trainees, Poster Walk leaders will provide context, thematic discussion, and curated knowledge to enhance your learning experience!
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Tamara Lotan, MD أُعيد تغريده
Samson W. Fine, MD
Samson W. Fine, MD@rovingatuscap·
Excited to Join @JHUPath Hopkins Pathology for a Career Development Session on How To Prepare for and Navigate National Meetings in advance of #USCAP2025 - thx @LotanLab for the invite!
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Tamara Lotan, MD أُعيد تغريده
Denis Wirtz
Denis Wirtz@deniswirtz·
Hopkins is recruiting 30 Bloomberg Distinguished Professors in AI + X (X = astrophysics, cancer, neuroscience, genomics, social sciences, etc.) hub.jhu.edu/2024/12/17/dat… 22 of these 30 will be organized in clusters:
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Tamara Lotan, MD أُعيد تغريده
Joey's Wings Foundation
Joey's Wings Foundation@Joeyswings·
Trailblazer Award – $75,000 in partnership with @KidneyCancer was granted to Dr. Kaushal Asrani of Johns Hopkins University School of Medicine! This research project: Therapeutic Targeting of EGFR and HER2 in Translocation Renal Cell Carcinoma.
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Tamara Lotan, MD أُعيد تغريده
dahlia kurtz ✡︎ דליה קורץ
This is October 7. And you must bear witness. The KiIIing Roads is a raw documentary of that Black Saturday — with about 50% of never-before-seen-footage. Yes. This will punch you in your heart — over and over. The filmmaker Igal Hecht has made it free for all. Please share.
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Tamara Lotan, MD أُعيد تغريده
Kaushal Asrani
Kaushal Asrani@AsraniKaushal·
Excited to share our joint review with @NicolaAlesi @LisaHenske @LotanLab on the ever-expanding role of the MiT/TFE factors as upstream activators of mTORC1 and drivers of renal tumorigenesis #TSC #BHD #tRCC #TFEopathies #mTOR
Physiology (APS Journal)@physiol_journal

#ArticlesInPress: "The Spectrum of "TFEopathies" - Flipping the mTOR Switch in Renal Tumorigenesis" by Alesi et al. ow.ly/bA2e50SE867

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Tamara Lotan, MD أُعيد تغريده
Scott Eggener
Scott Eggener@uroegg·
Hard to imagine a future without AI pathology: - outperforms high-quality pathologists - provides the % of Gleason pattern 3, 4, and 5 Predicting prostate cancer grade reclassification on active surveillance using a deep Learning-Based grading algorithm academic.oup.com/jnci/article-a…
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Tamara Lotan, MD أُعيد تغريده
International Society of Urological Pathology
Join the #ISUP “Consensus Conference on GU Precursor Lesions,” open to all in pathology, urology, and oncology. #ISUPItaly2024 🇮🇹 Complete the pre-meeting survey from all 5️⃣ working groups. Your input matters! 🔗: surveymonkey.com/r/BPNZ65X 🗳️ Voting Period Ends: June 30
International Society of Urological Pathology@IntSocUropath

#ISUP Upcoming Event 2024 ISUP Italy Multidisciplinary Consensus Conference on Precursor Lesions of Genitourinary Organs #ISUPItaly2024 🇮🇹 📅 12 Sept 2024, immediately following @ESP_Pathology #ECPItaly2024 Register here: ISUP-ITALY-2024.eventbrite.com

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Tamara Lotan, MD أُعيد تغريده
The Hill
The Hill@thehill·
House launches email address to report college antisemitism amid investigation trib.al/L3aaP90
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Tamara Lotan, MD أُعيد تغريده
Alex Thompson
Alex Thompson@AlexThomp·
WH spokesperson Andrew Bates responds to this hearing yesterday: "It’s unbelievable that this needs to be said: calls for genocide are monstrous and antithetical to everything we represent as a country."
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Bill Ackman@BillAckman

The presidents of @Harvard, @MIT, and @Penn were all asked the following question under oath at today’s congressional hearing on antisemitism: Does calling for the genocide of Jews violate [your university’s] code of conduct or rules regarding bullying or harassment? The answers they gave reflect the profound moral bankruptcy of Presidents Gay, Magill and Kornbluth. Representative @EliseStefanik was so shocked with the answers that she asked each of them the same question over and over again, and they gave the same answers over and over again. In short, they said: It ‘depends on the context’ and ‘whether the speech turns into conduct,’ that is, actually killing Jews. This could be the most extraordinary testimony ever elicited in the Congress, certainly on the topic of genocide, which to remind us all is: “the deliberate killing of a large number of people from a particular nation or ethnic group with the aim of destroying that nation or group” The presidents’ answers reflect the profound educational, moral and ethical failures that pervade certain of our elite educational institutions due in large part to their failed leadership. Don’t take my word for it. You must watch the following three minutes. By the end, you will be where I am. They must all resign in disgrace. If a CEO of one of our companies gave a similar answer, he or she would be toast within the hour. Why has antisemitism exploded on campus and around the world? Because of leaders like Presidents Gay, Magill and Kornbluth who believe genocide depends on the context. To think that these are the leaders of Ivy League institutions that are charged with the responsibility to educate our best and brightest. On the bright side, our congressional leaders deserve accolades for showing tremendous leadership and moral clarity in their statements, by the questions they asked, and the respectfulness with which they conducted the hearing. It was a masterclass of how our government and democracy should operate. If you have time, please watch the entire hearing. Throughout the hearing, the three behaved like hostile witnesses, exhibiting a profound disdain for the Congress with their smiles and smirks, and their outright refusal to answer basic questions with a yes or no answer.

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Tamara Lotan, MD أُعيد تغريده
JCO Precision Oncology
JCO Precision Oncology@JCOPO_ASCO·
.@LotanLab et al. highlight challenges associated with commercial molecular assays in evaluating MLH1-deficient prostate tumors ➡️ fal.cn/3yKbl #pcsm
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Tamara Lotan, MD
Tamara Lotan, MD@LotanLab·
@GladellPaner @drmehrarohit We have a new mouse model of SFPQ-TFE3 carcinoma with very similar bi-phasic pattern—would be interested to know fusion partner in this case!
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Gladell Paner, MD
Gladell Paner, MD@GladellPaner·
This #renal cell carcinoma shows biphasic pattern and … PRCC:TFE3 fusion on RNA-seq 😳 Biphasic pattern is more associated with TFEB-rearranged RCC. This TFE3 RCC also has other patterns. #GUPath @drmehrarohit
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