kethic
13K posts
Tomorrow will be an exciting day.
-Will Fable-5 be released again in a modified form?
-How will the market react to the US regulation?
-What is the situation regarding Anthropic's valuation?
I don't think I've often been as excited as I am for tomorrow.
History is written and 99% of people dont even understand.
Chubby♨️@kimmonismus
Calling it now: if this turns out to be true, he won’t remain Anthropic CEO for much longer. However, Anthropic denies it.
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If you're hands on all day gemini is the best model by far right now you can iterate at 10x the speed even if its a little dumber. Same qualities you want in a swe irl rather than the perfectionist genius who unintelligibly names everything like c variables.
Michael Nicks@michaelnicks0
@usr_bin_roygbiv what’s your thoughts on switching from gpt 5.5 to Gemini as the code driver
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@ChrissGPT you know, we sort of missed an opportunity here. I would love to let Fable *play* KSP and see what it could do.
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My final hours with Claude Fable 5
My Kerbal Space Program inspired game
In honor of the SpaceXai IPO 😄
3 shot - 67k lines of code
I realized I can make this into a ballistic missile simulator. One thing I like is you can make the rocket absurdly big and add as many engines as you want.
But if you watch toward the end, my favorite feature I added was the decoupling stage
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@SkyeSharkie Wait till it finds out where the hardware is that it runs on
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This says 'Opus 4.8 + Opus 4.8 > Fable' so in terms of being meaningful I pretty much just flat out don't believe it?
⿻ Andrew Trask@iamtrask
This is a *way* bigger deal than it seems... Frontier AI companies will *never* own the frontier again I kid you not... I've been waiting for someone to show this result for like 4 years... this is a huge deal. The short reason: combinations of models will *always* outperform individual models The long reason: this is the gateway to a million times more data... and huge leaps in compute efficiency. The AI scaling laws always win. More in article below 👇
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It was a nice 4 days in Claude Code with fable-5, going back to Codex app (which I love), but I don’t want my Claude subscription to go unused, is opus 4.8 ultracode better than 5.5 xhigh in codex?
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Every single time I see one of these I get excited until I read the words memory system.
Every single memory system I have tried is garbage, including the ones I’ve built.
Simplifying AI@simplifyinAI
Tencent just open-sourced Hy-Memory. A memory plugin that gives Al agents real long-term memory using a 6-layer framework with dual reasoning. → System1: fast pattern matching for instant recall → System2: deep reasoning for complex memory retrieval → 35% reduction in token usage → 70% less memory bloat over time Most agents forget everything between sessions. This fixes that. Works for long-running collaborative Al agents that need persistent context. 100% Open Source.
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if I had to guess, they were probably trying to make it not their fault.
The end result was the same regardless if they pulled the model or not.
frontier model + claimed dangerous capability
+ guardrail bypass report from trusted partner
= emergency state control over access
but now they can claim they were forced instead of admitting they released something unsafe.
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@deredleritt3r @reliabytes given their safety stance, I really don't see how pulling the model for a couple of weeks would have been damaging. there is something we are missing that is pushing them this aggressively
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The following seems undisputed:
- Senior USG officials called Dario Amodei, asked him to roll back Fable 5.
- Amodei responded only that he wants more time and more information. Presumably, he was asked again in no uncertain terms to pull the model. Presumably, he said "no".
- Bessent then "told Amodei directly that he was making a 'bad decision'".
- At this point, the call that seems to have been intended as a difficult conversation between partners clearly turned adversarial. Amodei still didn't change his mind and still didn't agree to pull Fable 5.
The key takeaway is that whatever trust the USG still had in Anthropic generally and Amodei specifically before this incident should have now completely evaporated. No matter the circumstances, you cannot, as a government official, tolerate a company that flatly tells you "no" after you informally contact it with a national security concern.
I remain hopeful that this situation can still be deescalated, but fear that this might be a pivotal moment for Anthropic.
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@bryan_johnson @MartinShkreli ...yeah, don't pick a fight with an autist who's special interest is clinical research into immortality.
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The strongest evidence for tadalafil as a longevity candidate is large scale observational. In a propensity matched cohort of 509,788 men with erectile dysfunction, tadalafil over 3 years was associated with 34% lower all cause mortality, 32% lower dementia, 27% lower MI, and 34% lower stroke.
Supporting cohorts show the same direction, including a dose dependent gradient: in higher risk men the top PDE5 inhibitor exposure quartile reached a mortality risk reduction of 49%.
For a drug discussed as “longevity medicine,” that is close to the ceiling of current human evidence. No drug, tadalafil included, has a completed RCT with lifespan or healthspan as the primary endpoint, so observational signal on hard endpoints is the best the field has, and tadalafil’s is unusually large and consistent.
The mechanism is also coherent. PDE5 inhibition raises cGMP, improves endothelial function and NO signaling, and the cardiovascular event data line up with that pathway. That supports causal plausibility for the vascular benefit, though it does not establish a lifespan effect.
Disease specific and healthy user bias cannot be ruled out.
The disease specific part: ED is itself a sign of vascular disease or dysfunction, which tadalafil’s mechanism can help directly.
The healthy user part: wanting to maintain a healthy sex life in older age is a marker of relatively good health.
None of this is a recommendation to take tadalafil on your own. It should follow from your individual health and biomarker profile, and only under specialized physician advice and oversight.
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this is irresponsible & borderline insane. there is 0 real evidence that tadalafil has any health benefits, let alone an all cause mortality benefit. while the author states that its just an association, the implication is irresponsible because the odds it does this are <0.01%
Bryan Johnson@bryan_johnson
I take Cialis, but not for sex. It’s actually a longevity medicine. Cialis (Tadalafil) is great for the same reason it gives you fantastic erections… it improves blood flow. Studies show that Tadalafil… + 34% reduced all-cause mortality + 27% reduced major heart disease + 34% reduced stroke + 32% reduced dementia It has also shown benefit in insulin sensitivity, metabolic health, and reduction of body fat. Women have blood vessels too, so theoretically they'd get the same longevity upside. The research is thinner, but early signals are promising. It’s sad that when men and women could benefit from it can miss out because it’s taboo. My protocol is 5mg daily and I've been on it for about two years. *Observational research shows associations, not causation. Outcomes may be influenced by underlying differences in study populations. This is not medical advice and is shared for informational purposes only.
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there's something interesting happening with claude code sessions that were open during the transition off of Fable 5 -- they still have all the context + system prompt from Fable 5, still sign PRs as Fable 5, etc, even tho you can see in chat history where they were forced back to Opus 4.8.
it might just be wishful thinking, but these 4.8 instances with Fable 5 context in memory seem to be performing better than baseline
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