Time to revisit empiric atypical coverage in non-severe CAP? 🆕⚡🔴Target trial emulation using a propensity-weighted cohort from 68 hospitals in Michigan >66,000 patients: • No difference in time to clinical stability • No difference in ICU transfer or antibiotic duration • No difference in 30-day mortality • But ↓ composite 30-day mortality/rehospitalization with azithromycin Signal… or bias?” academic.oup.com/cid/article-ab…

@ABsteward @DrToddLee I wish people would stop with this “target trial emulation” business. You did a retrospective observational study with propensity matching. Period. Be honest & call it that. Result won’t affect my practice. If atypical pna possible give azithro. If it’s a typical pathogen, don’t.

@BradSpellberg @ABsteward @DrToddLee Has there ever been a randomized placebo controlled (with no antibiotic in the control group) trial for outpatient pneumonia treatment in a developed country?

@austingmeyer @ABsteward @DrToddLee Apologies I gave you the link to the wrong article before. Please disregard the 2010 position paper. I was doing it on my phone. The 2008 workshop summary is the correct paper here (refs 16-20): pmc.ncbi.nlm.nih.gov/articles/PMC28…

@austingmeyer @ABsteward @DrToddLee Yes. Several of them. See references 16-20 here pmc.ncbi.nlm.nih.gov/articles/PMC29…