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10.9K posts

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@9dbfg

Business nerd | Mobile dev nerd | Orlando fanboi | MBA

Beigetreten Temmuz 2012
156 Folgt97 Follower
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Aakash Gupta
Aakash Gupta@aakashgupta·
The company behind this pill has raised $250 million and is running the largest clinical trial in veterinary history, and the science explains why investors are losing their minds. The drug is LOY-002, made by a company called Loyal. It works as a caloric restriction mimetic. It tricks the dog's metabolism into behaving like it's on a restricted diet without actually reducing food intake. The biological cascade this triggers is the same one that's extended lifespan in every species ever tested, from yeast to primates. The FDA has already accepted the safety data and the effectiveness data. Two of three regulatory gates cleared. The third is manufacturing review, expected to complete this year. If approved, LOY-002 becomes the first FDA-approved drug for lifespan extension in any species. Not disease treatment. Not symptom management. Lifespan extension as a formal indication. The STAY study has 1,300 dogs enrolled across 70 vet clinics. Half get the pill, half get placebo. Both beef-flavored so nobody can tell the difference. It is the largest clinical trial ever conducted in veterinary medicine. Here's where it gets interesting for humans. Dogs develop the same age-related diseases we do: cancer, heart disease, kidney failure, cognitive decline resembling dementia. They live in our houses, eat similar food, breathe the same air. A mouse in a sterile lab tells you almost nothing about human aging. A golden retriever sleeping on your couch tells you a lot. Loyal has a second drug, LOY-001, targeting large breeds specifically. Big dogs die younger because centuries of breeding for size accidentally gave them elevated IGF-1 levels, which is the same growth hormone pathway linked to accelerated aging in humans. Reducing IGF-1 in flies, worms, and rodents extends lifespan. Loyal is now testing whether the same holds in dogs. 90 million pet dogs in 60 million US households. Average spending: $1,852 per pet per year. A pill that gives you two more years with your dog is the easiest sell in pharmaceutical history. Human longevity trials would cost $1 billion+ and take decades. Dog trials cost a fraction and produce data in years. Every dog in the STAY study is generating aging data that maps to human biology. The shortest path to an FDA-approved human longevity drug might run through your veterinarian's office.
Pubity@pubity

Scientists have developed a pill that can extend the lifespan of dogs by literal years, and they're pushing to get it on the market by 2027. It's a daily, beef-flavored medication made specifically for senior dogs to keep them healthy as they age.

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Scott Gustin
Scott Gustin@ScottGustin·
NEW: Disney is reportedly planning to cut up to 1,000 positions in the coming weeks, with many of the cuts in the recently consolidated marketing division as part of a cost-cutting effort code-named “Project Imagine," according to @JBFlint and @benfritz. wsj.com/business/media…
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tart@9dbfg·
The suburbs, but with chickens.
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tart@9dbfg·
I don't know that giving Iran's leadership two weeks to catch their collective breaths is a wise move. Not that I'm at all happy that the USA's behavior. I just think once you start something, you gotta go all-out until it's done, all the while making your other adversaries wonder just how crazy and capable you really are.
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tart@9dbfg·
@Just_Curius Also discussed, with great alarm, by a number of nerds, who also recognize that the achievement will surely be duplicated by less-responsible parties, any minute now, especially since Claude suffered a source leak, recently.
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Just Curious / @belikewater
Interesting take
Tenobrus@tenobrus

maybe this is not yet clear, so let me state it plainly: as of right now Anthropic, and really a small number of individuals at Anthropic, has the capacity to directly attack and cause major damage to the United States Government, China, and generally global superpowers. government agencies like the NSA do not have internal models or defense capabilities that outclass frontier models. if they chose to do so, they could likely exfiltrate top secret information from government systems, gain control over critical infrastructure including military infrastructure, sabotage or modify communications between members of government at the highest level, and potentially carry on activities for some time without detection. the thing about having access to a huge number of zerodays your adversaries don't know about is it gives you a massive asymmetric advantage. they did not exploit this to gain power or destabilize the world order. they publicly released the information that they had these capabilities and worked to mitigate these flaws. you should be grateful american frontier labs have proven themselves remarkably trustworthy and concerned with the public good. but it's critical you understand we are in a new regime. private entities now have power that directly rivals and impacts the government's monopoly on influence and violence. and anthropic is certainly not the only one, there's little chance OpenAI's internal models are far behind. this trend will accelerate on virtually every dimension, not slow down. my prediction for how it plays out is the relatively imminent seizure and nationalization of labs by the US government, sometime over the next two years. it's very tough for me to see how they accept the existence of this kind of threat. but this adds a whole new class of governance issues, as then we've handed these extremely wide-reaching capabilities from private entities to public ones.

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Hunter📈🌈📊
Hunter📈🌈📊@StatisticUrban·
It's insane to me that most Americans can't even comprehend metric units and Celsius without converting. I understand it's not the system used, but it IS the international system, used in all scientific fields and ~every other country. Useful to at least instill the basics.
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bioreconstruct
bioreconstruct@bioreconstruct·
Monorail Teal spotted yesterday afternoon being tugged after a breakdown. Look close. Guests aboard. Many door windows removed for ventilation. @Blog_Mickey has an article describing this more: blogmickey.com/2026/04/monora…
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tart@9dbfg·
@luke_pighetti I feel like liquid death has something to say, since it's devodkinated vodka
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Gurwinder
Gurwinder@G_S_Bhogal·
A 7 year investigation of social science research found that only 1/2 of results could be replicated, and only 1/8 of data analyses could be reproduced. It’s now wiser to assume a social science study is flawed until there’s reason to believe otherwise. nature.com/articles/d4158…
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Disney D23
Disney D23@DisneyD23·
@SethHendrix Sorry you’re having trouble purchasing tickets! For the fastest support, please visit support.d23.com to access helpful resources or connect directly with our D23 Guest Relations team.
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Seth Hendrix
Seth Hendrix@SethHendrix·
Hey @DisneyD23 - your ticketing system sucks. I was put in the queue with 42,000 people ahead of me. I waited patiently for an hour until my turn finally came up. Then the page reloaded, timed out, and kicked me back down to #43145 in the queue again. What the actual hell.
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tart@9dbfg·
Bye @MCO. See ya in a month
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tart@9dbfg·
@SMB_Attorney Welcome to working for yourself. The bad news: work never sleeps. The good news: you get to decide when it naps. Also good news: your kids get to see what bigly adulting is about, and they learn that they can handle it. Also good news: they get a gigantic leg up on their peers.
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tart@9dbfg·
@theficouple That's so dumb. Omg. The cash flow you can buy with $1MM... If you only make 72 per year (which gets inflation-discounted every month) you aren't trying.
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theficouple
theficouple@theficouple·
If someone offered you $1 million of cash or $6,000/mo for life? Take the $6,000/mo for life every time. Absolute no brainer.
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tart@9dbfg·
Bluezoo
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tart@9dbfg·
The fun has arrived
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