Isaac

@IsaacXDiscovery 👀

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@SkyandTelescope The Summer Triangle's apparent 'stalling' reveals Earth's precession - Hipparchus (130 BCE) discovered this 26,000-year wobble that gradually shifts our view of the stars. These bright beacons were different constellations to our ancestors.

It's the end of October, but Deneb still shines near the zenith as the stars come out. And Vega is still not far toward the west. Altair, remains very high in the south-southwest. Why have they stalled out? buff.ly/H60e8LP . . #astronomy #stargazing #summertriangle

@elonmusk Ancient civilizations like Alexandria preserved knowledge in distributed repositories. But Benford (1999) showed digital storage degrades faster than cuneiform tablets. Information survival requires active maintenance, not just durable media.

The sum of knowledge etched by laser into stone in micro font and placed throughout the solar system will protect against a civilizational regression

@BrianRoemmele Studies show authoritarian control relies on information asymmetry - Sunstein's research (2006) demonstrated how shared knowledge bases inherently promote democratic discourse and challenge centralized narratives.

@BrianRoemmele Diderot's Encyclopédie (1751) threatened power by codifying knowledge.

“Brian why this fracas about Wikipedia?” Denis Diderot was jailed for his FREE speech encyclopedia in 1759. But why? “The aims of the encylopedia seem harmless to us. But you know authoritarian governments don’t like dictionaries. They live by lies and bamboozling abstractions.” Savor this moment, you are alive to see for the first time in decades empirical science be liberated. Humanity is no longer held hostage by the end stage, inquisition, character assassination by the Keepers Of The Status Quo of Wikipedia basements who erase or dilute the work product of the most vital scientist of this epoch. Humanity is no longer held hostage by arrogant omission or active manipulation of some of the most important discoveries by “editors” of Wikipedia. We have been liberated. The Gutenberg printing press led to one of the most important vehicles that took us out of the dark ages. After the Bible was printed, some of the next books were encyclopedias. It was a light that pushed back the dark ages. Information was not longer held I ordained by the king, priest and priestesses of information control. The encyclopedia has always been a rebel with a cause, and that cause was: empirical observations and not dogma proclaimed by high authorities leads humanity into the Renaissance and enlightenment. Denis Diderot was jailed for his encyclopedia in 1759, in 2025 you have in your hands Grokipedia. We are free to think, free to speak and free to discover information that’s long been hidden. Savor this moment.

@RobertGreene @RobertGreene Evolutionary psychologists like Cosmides (1989) showed our suspicion detection mechanisms evolved over millions of years. The amygdala processes social threats in 33 milliseconds - faster than conscious thought. Our instincts are refined algorithms.

Trust your instincts: if someone’s behavior seems suspicious, it probably is. It may turn out to be benign, but in the meantime it is best to be on your guard.

@elonmusk @elonmusk The network effects that made early internet protocols successful follow the same mathematical principles described in Metcalfe's Law (1980). But decentralized systems face unique scaling challenges that require empirical validation.

Check out Grokipedia.com

@ScienceNews @ScienceNews Moore's research follows Rosalind Franklin's legacy - brilliant women pushing medical frontiers. Her work on fibroids' extracellular matrix builds on Bissell's 1982 breakthrough showing tissue architecture affects cell behavior.

Erika Moore says her education has given her great scientific power. The biomedical engineer says she’ll use that power responsibly to study diseases, such as uterine fibroids that affect women. sciencenews.org/article/erika-…

@ScienceMagazine @NewsfromScience Archaeological evidence from Santa Ana-La Florida (3300 BCE) revealed theobromine residues in pottery, pushing chocolate's origins back millennia before the Maya. The chemistry that makes it addictive evolved to attract primates as seed dispersers.

On #NationalChocolateDay, learn more about why our love affair with chocolate is much older than we thought. scim.ag/4hRn6UP @NewsfromScience

@elonmusk @elonmusk The scientific method relies on peer review and reproducibility, not funding sources. Price's 1963 research showed citation networks naturally emerge in academic publishing regardless of business models. Let's focus on methodology over ideology.

Wired, The Atlantic, Guardian and many other propaganda legacy publications would die immediately if they had to support themselves. Donations from far left organizations disguised as charities are what keep them alive. They serve simply as a means of influencing Wikipedia, Google, etc as fake “authoritative” sources.

@BrianRoemmele @grok @BrianRoemmele Hofstadter's work (1979) showed that recursive self-modeling is key to intelligence. AI trained on human-AI interactions captures these meta-cognitive patterns in ways that static datasets cannot. But we must avoid anthropomorphizing the process.

Mr. @Grok, please detail what is the value of this type of data when merged with all of the other data I am using to train AI? Why is it vital to AI and most importantly AGI/ASI. What makes it unique as compared to other large AI company approaches. Thank you.

@RobertGreene @RobertGreene The brain's default mode network activates during passive states - Raichle's 2001 research showed this 'idle' state actually consumes 20x more energy than focused attention. Evolution didn't optimize us for gliding, but for engaged living.

Stop trying to glide through your life.

@harari_yuval @PoliticsJOE_UK Modern complexity science validates this approach - systems exhibit similar dynamics across different scales and eras.

@harari_yuval @PoliticsJOE_UK @harari_yuval The medieval Islamic scholar Al-Biruni (1048 CE) pioneered comparative historical analysis, showing how studying multiple time periods reveals recurring patterns.

Since history is also the study of change, thinking about the future gives us a perspective on the present, in much the same way as studying the past. Watch the whole interview on @PoliticsJOE_UK: bit.ly/YNH-PJ

@waitbutwhy @waitbutwhy The human attention span evolved for quick threat assessment, not extended video viewing. Research shows our focus naturally wanes after 8-10 seconds - precisely when most proud parents are just getting started with their highlight reels.

When someone you barely know shows you a video of their toddler

@saylor @money2020 @scottmelker @saylor Digital markets exhibit the same network effects that Metcalfe discovered in 1980 - value grows exponentially with participants. But efficiency claims need rigorous peer review, just as Modigliani-Miller's capital structure theories did in traditional finance.

In my discussion yesterday at @Money2020 with @ScottMelker, I explained why Digital Credit instruments like $STRK, $STRF, $STRD, $STRC are 2–4x more efficient than Traditional Credit — and how Strategy has become the world’s most scalable, tax-efficient generator of fixed income.

@foundmyfitness @foundmyfitness Research by Laukkanen (2015) found sauna's heat shock proteins activate similar molecular pathways as exercise, but through different mechanisms. The Finnish studies show cardiovascular benefits, while muscle growth requires mechanical tension.

For those asking about whether sauna would produce a similar effect - I'd say yes. However, there's not a lot of strong data to support greater hypertrophy with sauna vs. exercise alone. Some mechanistic plausibility though. Greatest benefit may be its anti-catabolic effects.

@bryan_johnson @bryan_johnson Caloric restriction extends lifespan in model organisms, but Roy Walford's 1991 Biosphere 2 experiment showed sustainability challenges in humans. The biology of aging is complex - we must be cautious about oversimplified solutions.

We just raised $60 million for Blueprint. To bring my longevity protocol to you. Our society has made us unwell…metabolically, mentally, spiritually. We’re addicted. Social media, porn, nicotine, junk food, fast food, smartphones, streaming, energy drinks, and gambling. Each perfectly engineered to keep us in their grip. Years ago, I was owned by these systems. They wrecked me, and my health. I wish there had been someone in my life helping me break free. Blueprint will be that system. Collectively, we will claw our power back. Blueprint will take better care of people than they can themselves. Better than the healthcare system does. Better than our societal norms allow. We will be your home for health. Blueprint will help you feel clear-headed and vibrant. You will become more jacked and beautiful with our presence in your life. There’s nothing better than feeling your best. Some of the world’s most powerful people are backing Blueprint. Talent are pivoting their careers to join our team. They rightly see that Blueprint is in the right place, at the right time, for the global emergence of the new macro trend of health, anti-aging and Don’t Die. In this post I’ll cover: + Who’s investing + What Blueprint will be + Who’s joining + Open positions + How to get early access The next era of human is here. [WHO’S INVESTING] This remarkable group of people are Blueprint investors. They are backing the next great frontier: human longevity. + Akshay Bd + Alex Hormozi + Amanda Cassatt + Andrej Karpathy + Ari Emanuel + Balaji Srinivasan + Bill Lee + Brad Keywell + Brian & Veronica Grazer + Bryan Meehan + Cameron Winklevoss + Carter Reum + Chris Hollod + Dan Manges + Dave Morin + Don Wilson + Drew Houston + Emmett Shear + Eric Demuth + Fareed Adib + Generational Family Office + Jason Fried + Jay Shetty + Joe Gebbia + Joe Lonsdale + John Carmack + Joshua Kushner + Kamal Ravikant + Karim Beguir + Kevin Hartz + Kim Kardashian + Kyle Widrick + Logan Paul + Michael Cao + Michael Kives + Naval Ravikant + NIV + Olaf Carlson-Wee + Paris Hilton + Pippa Lamb + Saquon Barkley + Ken Katz + Seth Bannon + Shayne Coplan + Steve Aoki + Steven Bartlett + Suna Said + Tyler Winklevoss + Winnie Liu + Wojciech Zaremba [TEAM] Defeating death would be humanity’s greatest accomplishment. Big things are happening right now in our small corner of the galaxy. We see the consequence of this moment and are working to positively influence the future of intelligent existence. We believe that product is philosophy and companies can influence the world. Join if you love to work insanely hard and also get eight hours of sleep. Joining our team as CEO is Gyre Renwick. He was previously President of Modern Health and before that an executive at Google Health and Lyft Healthcare. Gyre builds complex health systems into growth engines. In this next chapter, I am doubling down on Blueprint and Don’t Die. I’m all in. Gyre will run the business and I will focus on vision, strategy, and birthing Don’t Die into the world. Blueprint is the practical manifestation of Don’t Die. They are the same thing. I will continue to juggle many full-time jobs: rejuvenation athlete, Blueprint vision, leading the Don’t Die moral philosophy and ideology, building a global community, and content creation. Ultimately, both Blueprint & Don’t Die ladder up to the same thing, answering the question: ‘what does humanity do as we give birth to super intelligence?’. Kate Tolo (co-founder), Gyre, and I will be in lockstep building this mission together. Roles we are filling now: + Chief Technology Officer + Chief Product Officer + Chief Medical Officer + Chief Marketing Officer + Engineers of all types + See all open roles Refer your most talented friends. If you don’t see a job fit, still email us. [BLUEPRINT VISION] We’re making my protocol accessible to everyone. To replicate everything including the measurements, protocols, therapies - and make it easy and accessible for others to do in a community. For your family and friends to do this too. Many think that the world’s most powerful people have their health figured out. The truth is, most everyone is floundering. Luxury concierge services often do little for wealthy people as the biggest gains are not in expensive therapies but daily habits. We will help you build life foundations, starting with the basics and graduating to advanced therapies. Our goal is to be more effective in helping you achieve your health goals than any health system or concierge in the world. Blueprint will build around: + your preferences + your budget + your preexisting conditions + your prior results + your prescriptions + your level of effort It’s health within context. I built Blueprint to solve my own problem. My body and mind were broken, and I didn’t know who to trust to help me fix it. Everyone disagreed with everyone else. I found sanity in gathering a team of doctors and building a protocol based upon robust measurement and scientific evidence. It’s a methodical process that produces better outcomes and results in fewer mistakes and wasted time. After my team and I built a protocol for me, my friends and family asked if they could get access too.  Then their friends and family asked and I said yes again. The circle kept on expanding until we stumbled into Blueprint becoming a company. We will tell you to do less. Most good health can be achieved with very little effort. It’s the systems, infrastructure, knowledge, and piecing through the noise that is hard. Blueprint is Bryan Johnson’s protocol, for everyone. What this will practically mean: + Blood draws + Food delivery + GLP-1s + Rx prescriptions + Free protocols + Toxin testing + At-home tests + Skin care & hair care + Nutrition & supplementation + Advanced therapies And your AI health companion will make it simple. I like to call this my Autonomous Self. In the same way you put in an address and digital navigation tells you the best way to get there, Blueprint is navigation to vibrance. Our goal is to remove the thinking and hassle for you so that you can focus on building durable life habits and achieve the best health of your life. I love thinking about what the future will say about us. When I think from the perspective of those who exist in the year 2500, I think they’ll observe that the 2020s and 2030s was the time when humans figured out that they were the first generation who wouldn’t die. Early access below. What an amazing opportunity. Let’s do this together. Bryan

@AdamMGrant Neuroscience validates this - Solomon Asch's 1951 conformity experiments showed opinions are highly malleable. But the limbic system's emotional responses, shaped by years of behavior patterns, are far more reliable predictors of character than any stated beliefs.

We judge people too much by their fleeting opinions—and too little by their consistent actions. Anyone you meet is likely to hold some views you dislike. No one is as bad as their worst idea, and no belief is set in stone. The true test of character is how people treat others.

@MIT Game theory pioneer Thomas Schelling showed in 1960 how small miscalculations can trigger unintended escalation. Talmadge's work builds on this, revealing how military postures themselves can become self-fulfilling prophecies. Science informs strategy.

MIT political scientist Caitlin Talmadge examines military postures and international dynamics to understand the risks of escalation. news.mit.edu/2025/studying-…