AxonalPlasticityLab

@FreAmeLie @NWOFunding @AmsNeuroscience @amsterdamumc @FGA_lab 🥳🥳🥳🥳🥳 The AIS will really get its deserved spotlight now. @FreAmeLie and @adorrego_r with two major grants spearheading the field! All the best to you!

Incredibly happy to share that @NWOFunding has funded our #VIDI project 🥳 We will unravel the mechanisms controlling the composition of the axon initial segment and how this participates in keeping neuronal network activity in balance! @AmsNeuroscience @amsterdamumc @FGA_lab

Quite remarkable (understatement of the day!).

@CincinnatiZoo Oh look @jenkins_paul , your favorite animal ever. Also, they come with a smell of fresh cilantro. Just for you 😜

Rescued manatees Lilypad, Orchid & Vora are now swimming in Manatee Springs! They will be visible to the public starting Thursday. The Cincinnati Zoo is proud to serve as a second-stage rehabilitation facility: cincinnatizoo.org/three-orphaned…

@MattRasband And we all know your papers as a team 🤓Good job, mentor! And enjoy your time at SfN (I assume).

I am mostly silent on Twitter. But today I must post something: I met with three amazing and incredible women scientists I had the privilege of mentoring as PhD students in my lab. Dori Schafer, Shelly Buffington, and Tammy Ho. They helped make me who I am.

@VlachosLab @NeuroEichler You were missed Andreas!

Congratulations to Amelie Eichler @NeuroEichler for receiving this year's Young Investigators Award from the Anatomische Gesellschaft! …for her outstanding research on the role of microglia in rTMS-induced plasticity. #Neuroscience #YoungInvestigator #rTMS #SynapticPlasticity

Fantastic opportunity for candidates serious about top notch cell biology in combination with cutting edge imaging!!

@adorrego_r And I had such high hopes for you Ana ...😂

@AxonalLab A betrayal in plain sight…

Heading to #NeuroBioUK and using some train time to finish the slides 🤓

PNAS Inaugural Article published: "MINFLUX reveals dynein stepping in live neurons" by J.M. Schleske et al. Open access - read it at pnas.org/doi/abs/10.107… @mpi_mr_hd @mpi_nat @PNASNews #Optics #Imaging #Microscopy #MINFLUX #Fluorescence

@MedEckardt @MichaelOkun @UF @UFHealth @ScienceAdvances The ultrastructure work in this new paper is beautiful, and adds another layer of information for sure. All I'm saying is that the word "dogma" may be a bit exaggerated here.

@MedEckardt @MichaelOkun @UF @UFHealth @ScienceAdvances My thoughts exactly. I have been pointing out the PNS-liquor axes for years. Source: A detailed histology chapter in Benninghoff & Drenckhahn, Anatomie Bd. 2, Urban & Fischer (Elesvier). This is anatomy textbook knowledge! There is even clinical relevance to it (Tarlov-cysts).

Boom! Cerebrospinal fluid (CSF) flow extends to peripheral nerves. Alexander Ligocki, Ed Scott and colleagues @UF @UFHealth blow our minds. New paper @ScienceAdvances. What will we call it now? Cerebro-spinal-nerve fluid (CSNF)? or maybe brain-spinal-nerve fluid (BSN)? Just when you think you have a few ground truths of the brain and nervous system, you are humbled again. Key Points: - The authors point out that dogma holds that cerebrospinal fluid is responsible for 'maintaining brain homeostasis through nutrient delivery and waste removal for only the central nervous system.' - They show extensive CSF flow throughout the peripheral nervous system. - They traced multimodal 1.9-nanometer gold nanoparticles. - These nanoparticles were roughly the size of CSF circulating proteins. - They squirted them into the lateral cerebral ventricle. -They showed incredibly that the particles transitioned from central to peripheral nervous systems at root attachments and transition zones. - They showed the particles could make it all the way to the axoplasm of distal peripheral nerves. - Bigger 15-nanometer gold particles were not able to make the journey. My take: We know that the nervous system does not contain the more traditional lymphatics and has a force field called the blood brain barrier. We know that CSF delivers nutrients and removes waste from the brain and central nervous system. Our previous ground truth was established by studies using dye tracers. Using small gold nanoparticles these authors 'tore down the dogma.' So the real question is whether it is time for a name change? Cerebrospinal fluid (CSF) or cerebro-spinal-nerve fluid (CSNF)? or maybe brain-spinal-nerve fluid (BSN)? Thoughts? Sartor resartus – the tailor re-tailored our view on this important aspect of neuroscience. BRAVO! science.org/doi/10.1126/sc… #parkinson #CSF #cerebrospinal #Alzheimers

@christlet @adorrego_r Funny, this is what Matt Grubb said too ;-) No worries - the community made some real breakthroughs, one of them being that we will start working on an open science AIS platform to share protocols and troubleshooting help.

We’re starting!

@WinnerLab Fantastic news, all the best Beate!!

Congrats Beate 👏🏻👏🏻👏🏻

My research focuses on the axon initial segment in neurons. I’ll be expanding this work by combining efficient CRISPR genome editing techniques. I’ll be recruiting postdocs, grad students, technicians, and postbacs. If you're interested, please feel free to get in touch!

A dendrite is a dendrite is a dendrite? Dendritic signal integration beyond the “antenna” model link.springer.com/article/10.100…

@BrunoGiacomazzo @MicrobiomDigest @jamiezvirzdin THIS!! And funding agencies should re-think the entire "novelty" part of applications. We need a separate funding scheme for "reproducibility". Nobody is going to pay for that of course, but it is high time to think about it.

@MicrobiomDigest @jamiezvirzdin This is why it is important for scientific results to be reproducible. Journals should be more welcoming toward papers that reproduce results to double check.

AI can be used to make convincing looking fake data. There is no way we can distinguish real from fake anymore. It is safe to assume that genAI has already resulted in many fake papers. Scientific publishing is not prepared for this.

@adorrego_r in vivo or in vitro?

Not 1, not 2, but 3 AISs in this dopaminergic neuron 🧠

New publication focusing on one of the coolest cell types ever!

An evolutionarily conserved AnkyrinG-dependent motif clusters axonal K2P K+ channels rupress.org/jcb/article-ab…

And another piece of the puzzle .... great work @VictorMacarron and @ElisaDEste & team.