Lorenzo Brunetti

@NicoGagelmann ER big time

What's your favorite?

@Goodell_Lab @Gandhar_Datar @therealDrGundry @RibackLab @bcmhouston Seeing this come out is incredibly rewarding. A true paradigm shift for the NPM1 field — thank you for the opportunity to keep collaborating!!! Congrats to @Gandhar_Datar and @sciencyelmira for the immense work done.

@Gandhar_Datar joined the lab when the world was shutting down, having just gotten started with guidance from @therealDrGundry and @BrunettiLab, who then moved on in their careers. Tough work in isolation until @RibackLab joined @bcmhouston, when informal chats got us thinking about the project in a whole new way. We considered how the aberrant function of NPM1c was related (or not) to its nucleolar WT function. A great collaboration grew, with Gandhar deeply learning both hematology and biophysics! Many ppl world-wide contributed and @sciencyelmira was the closer, getting the in vivo models working. Thanks to all, including the reviewers and editors for feedback.

Hematology X biophysics = new leukemia pathogenesis paradigm! Our collaborative work with @RibackLab on NPM1c-mutant leukemia is live @CellCellPress! Multiple oncoproteins form similar nuclear condensates that massively drive leukemia-gene transcription!

Calorie restriction + aerobic/resistance #exercise is the winning combo in older adults with #frailty & #obesity: it improves body composition & insulin secretion. CNTF & IGF-1 might play a role! Grateful to @ESPENorg & @EASDnews Rising Star grants clinicalnutritionjournal.com/article/S0261-…

@Eddie_Cliff @Capt__Kirkwood @ComeBommier The best session of #EHA25! @EHA_Hematology @young_eha

Excited for our session on critical trial appraisal here at #EHA2025 in Amber 7&8 - @Capt__Kirkwood on randomisation - @ComeBommier on surrogate endpoints - me on postprogression care & overall survival - Fabio Efficace on patient reported outcomes #lymsm

A/Prof @Capt__Kirkwood give us some great examples from within haematology of the importance of randomization & types of bias that can crop up in its absence (and occasionally in its presence!) #EHA2025 @young_eha

Full room at the second session of YERM, chaired by @BrunettiLab and Alyssa Cull. Starting with @Nina_CabezasW lecture showing very cool data on the crosstalk between the HSC/bone marrow and the heart #EHA2025

If you're attending #EHA2025, make sure you don't miss the #YoungEHA Research Meeting (YERM) today. It starts off with an exciting session on "Erythropoiesis: From biology to pathology" at 8 o'clock in the Brown Hall 2!

@DelwelRuud kicking off the YERM at #EHA2025 - join us in Brown Hall 2!

Dr Stefano Rivella @ChildrensPhila with the first session on #erythroppiesis. Join us in Brown Hall 2! #EHA2025 #YoungEHA

Face-to-face meeting of the @young_eha committee, today in The Hague (NL) ! Lots of ongoing and future projects to serve young hematologists and help them achieve their full potential. You wanna be part of this adventure ? Please apply on the @EHA_Hematology website !

Before you go on Xmas holidays remember 👇👇👇 Deadline for abstract submission to join us at #EHAReCon2025 in Malaga on March 17-20 is January 8th !! I will be chairing the session on Transcripitional control with this fab lineup of speakers 🤩 @young_eha

@BianconGiulia @AIRC_it @policlinicoMI @YaleMed Yeeeees! :)

1/Excited to share our latest study showing that RNA sequestration in P-bodies sustains myeloid leukemia - now out in @NatureCellBio! nature.com/articles/s4155…. 🧵 below:

Our team @SCICambridge is expanding and we have now a very exciting opening for a Laboratory Research Technician/Assistant!!! More positions to be announced very soon. Help us spread the word 👇👇🔬🔬 jobs.cam.ac.uk/job/47567/

Today, at TLH, we summarise a decade of hard work. We wish to thank all colleagues, patients and relatives, who helped us during this amazing journey. thelancet.com/journals/lanha…

"We are convinced that #academic CAR T-cell therapy will play an increasingly important role in cancer therapeutics... It would be unfair to leave our patients to their own devices when there is so much we can do for them" In Focus #CARtx @hospitalclinic thelancet.com/journals/lanha…

We are proud to have had you as our Chair @MandyNLauw! Thank you so much🙏🏼 for all your hard work advocating for the role of #YoungEHA🌱 in @EHA_Hematology and #earlycareer professionals in #hematology, and look forward to continue your great work with our new Chair @drnborges !