Peggy Goodell

Amazing paper showing somatic mutations and massive clonal selection for lymphocytes that drive autoimmune disease. Autoimmune diseases are varied and individually relatively uncommon but as a group highly prevalent. These cause lots of morbidity to very many people, with huge personal, societal, and economic impact. If these findings are extended to other autoimmune conditions, they will have huge implications for treatment. Lots in this paper - somatic evolution, new tech, old theories, mutations in your favorite genes... The thread is a great TL;DR for the paper. Go deep and read the cited 2007 Goodnow paper (post#6) - amazingly detailed and prescient- from ~20 years ago!

@leonard_zon Congrats, Len!

Wonderful evening at the Fellows of the AACR Induction Ceremony. Fun and an honor to be inducted.

@imartincorena Wow! Congrats @imartincorena and team! Amazing tour de force! Huge contribution to understanding autoimmunity.

Here is the press release too, with some lovely words from Goodnow. [end] sanger.ac.uk/news_item/hidd…

Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] rdcu.be/fdqbr

@EinsteinMed @MontefioreNYC Congratulations Uli! Amazing!

Ulrich Steidl, M.D., Ph.D., a global leader in blood cancer & stem cell research, has been named Director of Montefiore Einstein Comprehensive Cancer Center & VP of Cancer Medicine. He will lead innovation in care, research & prevention. Read more bit.ly/41jOAfK #MECCC

@landau_lab @CD_AACR Congrats Dan! Awesome paper for the whole field.

Woohoo! So proud to be featured on @CD_AACR cover!

Data on factors impacting time-to-acceptance could be crowd-sourced. Major factors: - time before first editor desk decision (varies a lot by editor and journal) - review time (huge variation; also heavily influenced by the editors) - editor decision time after reviews come in (can be longer than one would think) – revision time (authors chasing very time-consuming experiments for the win; heavily influenced by (lack of) editor guidance, but also topic, model system...) - second round (all same variables) - possible appeal time (appeals are high at top journals and take even more time and can add to total time) Journals track all this data. Authors should have it too. Decent crowd-sourced data could be in ~real-time, and would help authors make informed decisions. I think many ppl would contribute data from their experience.

Great visit with an inspiring group of hematologists! 🙏

Exciting new study demonstrating durable DNA methylation reprogramming (editing) in hematopoiesis!

First (to my knowledge) manuscript describing a correlation between number of infections and incidence of clonal hematopoiesis (CHIP). Really important from the perspective of highlighting a possible modifiable driver of CHIP during aging. @ISEHSociety exphem.org/article/S0301-…

@RyanDhindsa @ABFbrain @CalebLareau @RNA_Life Congrats Ryan! All Star team!

Honored to receive funding from @ABFbrain to study viral etiologies of dementia/neuroinflammation with co-PIs @CalebLareau and @RNA_Life

@bloodgenes @NatureRevGenet @michaelpoeschla @BroadMPG @GRO_Broad @broadinstitute @DanaFarberNews @harvardmed @BostonChildrens @hhmi_science Nice comprehensive review! It will be useful for new lab members. And I love the vertical graphic!

🚨🧬🩸 Delighted to have this @NatureRevGenet review w/ @michaelpoeschla published today - Genetic Influences on #hematopoiesis: rdcu.be/e9vlD

An interesting question not addressed is the lifestyle differences of people with inactivating myostatin variants. You might guess that people with more muscle will excel in activities where those traits are valuable (e.g., athletics or certain jobs). Those activities might be self-reinforcing, further enhancing muscle growth and amplifying the apparent genetic effect over time. Lots more to learn, but a great investigation that will move the field forward. #aging #muscle #health

It’s also a testament to the incredible societal value of these huge biobanks, the careful genotyping, thoughtful phenotyping, and mechanisms to make these available for analysis. THANK YOU to everyone who participates as a subject, to all the researchers who have worked so hard on these incredibly valuable resources, and to the funding bodies with foresight to invest in these. UKB and similar are truly transformative IMO.

Remarkable new study showing that many individuals with genetic variants that disrupt the function of myostatin (a protein that normally inhibits muscle growth) have ⬆️muscle mass,⬇️ body fat, and ⬆️strength. Increased muscle mass is clinically desirable for #healthyaging and for countering muscle loss in various contexts (including use of #GLP1 agonists). Below, MRI images of a subject with above-average muscle mass (left) and average muscle mass (right) from the study. Congrats @davidjglassMD and colleagues! Link ⬇️

@AbdelWahablab @natgenet @KellyLBolton @WashU @IrenaeusChan @PuZhang09980432 Congrats all! Glad to see this out!

Excited to announce a paper out today in @natgenet.nature.com identifying an approach to mitigate the risk of therapy-related myeloid malignancies in patients with cancer. Collaboration with @KellyLBolton @WashU and led by @IrenaeusChan & @PuZhang09980432 nature.com/articles/s4158…

Important work w real translational potential for cancer patients. Built on foundational science developed over years. Congrats to all!

@yash_pershad @AlexBickMDPhD @VanderbiltMSTP @joevanamburg @rheumrob @brettheimlich Congrats, Yash! - and to Alex! You have impacted so many projects (including ours) in your PhD! I look forward to seeing what next!

Excited to share that I defended my PhD in Human Genetics 🧬 I am immensely grateful to my mentor @AlexBickMDPhD, my family, my co advisor Dan Roden, my labmates, the @VanderbiltMSTP, our amazing collaborators, my committee, and everyone who has supported me!

Somatic genomics as a discovery engine for biomedicine - a Perspective in Cell sciencedirect.com/science/articl…