Peggy Goodell

We recently launched an essay competition for which scientists described structural problems they run into. With nearly 200 submissions, we decided to give out 8 awards, instead of 3. A quick summary here 👇 1 / 5

@PracheeAC Really interesting competition! And great summaries of the essays, winners, and process on the blog. Congrats to the winners and to the @AsteraInstitute for putting this together!

Really fun to read these! Thanks to everyone who submitted! My own view is that it’s often useful to put your BEST ideas out in the open so they are more likely to happen rather than worry who will use or monetize or execute on them. Doing so may spark a thousand fires of change or refine/improve the ideas from people with totally different experiences and expertise. My own lens for how to view the submissions was which essays might influence others to think more deeply about the topic by us highlighting it. Less on the topic or the proposed solution, but the potential upside

Great to see innovation in publishing! Thoughtful progress by Editor in Chief of @BiologyOpen @gorelicklab

@nancykgillis @MoffittNews Congrats Nancy! I look forward to your continued great work!

Officially #tenured🤓 Still trying to figure out what it means, but I appreciate the vote of confidence. @MoffittNews

@bloodgenes @DMSabatini Huge congrats Vijay!!!

🙏 Deeply honored to receive the 2026 Warren Alpert Prize! This award reflects the work by so many to enable transformative therapies for sickle cell disease and thalassemia, and the power of human genetics to reveal biology and guide new treatments! hms.harvard.edu/news/2026-warr…

@BrainResilience @StanfordBrain @StanfordMed @StanfordDeptMed @Stanford @Baylor Thank you all for the excellent visit – it was great to talk to so many wonderful colleagues- sharing ideas and moving science forward. And thanks to the inimitable @BrunetLab for hosting!

Margaret ("Peggy") Goodell (@Goodell_Lab) of Baylor College of Medicine discussed her lab's research in a talk titled "Somatic Mosaicism and Aging: Cause, Consequence, or Clock?" at an Aging Research Seminar. Thanks, Dr. Goodell, for the insightful talk, and to all who joined!

Two Presidents of @BCMhouston! Excited to welcome Jakub Tolar as our new President and CEO! He brings enormous energy and enthusiasm to take BCM into the next era, bringing deep experience leading a learning health system and his own interests in clinical translation of basic discoveries. Also grateful for the 16-year leadership of Paul E Klotman, who brought us through financial challenges, the pandemic, and a changing academic landscape with calm and humor. He modernized medical education, our infrastructure, and bolstered our finances; we grew and evolved. We are in a fantastic position for the future. Hope to be recruiting soon- watch this space!

@imartincorena Congrats! Great to see in final form. And what an issue- shared with @VamsiMootha with a fantastic somatic mosaicism story, tracking clones using mitochondrial DNA variants, and the inimitable @stephxie with human HSCs that exhibit memory of inflammatory exposure.

Our autoimmunity paper is now OA in final form. We found a fascinating landscape of somatic evolution underpinning thyroid autoimmunity, where tens of B cell clones convergently lose immune checkpoints and some acquire 4-6 drivers over years of evolution. nature.com/articles/s4158…

@VamsiMootha Congrats! Fantastic study! #mosaicism #hematology

Delighted to share the final version of our story on mtDNA mutations and aging, published today. We show mtDNA mutation burden is a sensitive marker of somatic mosaicism (due to CHIP) in blood. Curious if this pattern will extens to solid organs, too. rdcu.be/fk4Ou

Amazing paper showing somatic mutations and massive clonal selection for lymphocytes that drive autoimmune disease. Autoimmune diseases are varied and individually relatively uncommon but as a group highly prevalent. These cause lots of morbidity to very many people, with huge personal, societal, and economic impact. If these findings are extended to other autoimmune conditions, they will have huge implications for treatment. Lots in this paper - somatic evolution, new tech, old theories, mutations in your favorite genes... The thread is a great TL;DR for the paper. Go deep and read the cited 2007 Goodnow paper (post#6) - amazingly detailed and prescient- from ~20 years ago!

@leonard_zon Congrats, Len!

Wonderful evening at the Fellows of the AACR Induction Ceremony. Fun and an honor to be inducted.

@imartincorena Wow! Congrats @imartincorena and team! Amazing tour de force! Huge contribution to understanding autoimmunity.

Here is the press release too, with some lovely words from Goodnow. [end] sanger.ac.uk/news_item/hidd…

Excited to share our latest work. Applying advanced single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune lymphocytes. [1/n] rdcu.be/fdqbr

@EinsteinMed @MontefioreNYC Congratulations Uli! Amazing!

Ulrich Steidl, M.D., Ph.D., a global leader in blood cancer & stem cell research, has been named Director of Montefiore Einstein Comprehensive Cancer Center & VP of Cancer Medicine. He will lead innovation in care, research & prevention. Read more bit.ly/41jOAfK #MECCC

@landau_lab @CD_AACR Congrats Dan! Awesome paper for the whole field.

Woohoo! So proud to be featured on @CD_AACR cover!

Data on factors impacting time-to-acceptance could be crowd-sourced. Major factors: - time before first editor desk decision (varies a lot by editor and journal) - review time (huge variation; also heavily influenced by the editors) - editor decision time after reviews come in (can be longer than one would think) – revision time (authors chasing very time-consuming experiments for the win; heavily influenced by (lack of) editor guidance, but also topic, model system...) - second round (all same variables) - possible appeal time (appeals are high at top journals and take even more time and can add to total time) Journals track all this data. Authors should have it too. Decent crowd-sourced data could be in ~real-time, and would help authors make informed decisions. I think many ppl would contribute data from their experience.

Great visit with an inspiring group of hematologists! 🙏

Exciting new study demonstrating durable DNA methylation reprogramming (editing) in hematopoiesis!

First (to my knowledge) manuscript describing a correlation between number of infections and incidence of clonal hematopoiesis (CHIP). Really important from the perspective of highlighting a possible modifiable driver of CHIP during aging. @ISEHSociety exphem.org/article/S0301-…

@RyanDhindsa @ABFbrain @CalebLareau @RNA_Life Congrats Ryan! All Star team!

Honored to receive funding from @ABFbrain to study viral etiologies of dementia/neuroinflammation with co-PIs @CalebLareau and @RNA_Life

@bloodgenes @NatureRevGenet @michaelpoeschla @BroadMPG @GRO_Broad @broadinstitute @DanaFarberNews @harvardmed @BostonChildrens @hhmi_science Nice comprehensive review! It will be useful for new lab members. And I love the vertical graphic!

🚨🧬🩸 Delighted to have this @NatureRevGenet review w/ @michaelpoeschla published today - Genetic Influences on #hematopoiesis: rdcu.be/e9vlD