Edward Grow, PhD

Excited to share our work on chromatin landscape remodeling in cloned embryos! 🐄🐄We started off w/ simple question: how does the somatic epigenome reprogram to prepare for the onset of transcription (EGA)? tinyurl.com/yc4wv76p

Congratulations to our incoming @UTSW_ObGyn residents! #MatchDay2026

David Botstein was one of the giants of genetics and genomics, my mentor, colleague and friend. nytimes.com/2026/03/20/sci…

Accessory subunits of PRC2 mimic H3K27me3 to restrict the spread of Polycomb domains dlvr.it/TRc8T3

Postdoc position now open in my lab at New England Biolabs. Focus is on exploring phage defence systems through biochem and structural biology. @NEBiolabs provides an academic research environment with the freedom of industry. Please take a look! 🤓🧫🧬 tinyurl.com/49phcyh6

1/ We are thrilled to announce that our American branch of the Laboratory of Human Genetics of Infectious Diseases (HGID) will relocate to @UTSWMedCenter in Dallas, Texas, effective July 1, 2026 J

We want you to be the best department you can be, paying below regional averages and with a high teaching load that minimizes the time available for research.

Remember how we used to tell you you weren’t a DEI hire? We were lying and now DEI is dead. You can fill in the rest, right?

📢📢My lab at @UUtah is officially open and I'm RECRUITING — especially techs/specialists and postdocs! Our research focuses on the neurobiology of interoception and learning/memory using tools from systems/comp neuro. Please share!🧠🏔️🏜️ Apply/more info: #positions" target="_blank" rel="nofollow noopener">zimmerman-lab.org/#positions

3D chromatin compartment of round spermatids encodes the spatiotemporal program of histone-to-protamine exchange in spermiogenesis biorxiv.org/content/10.648… #biorxiv_genomic

The Programmable Genomics Lab at @UMassGCB just officially launched our site! We have a "simple" goal: to develop synthetic regulatory elements that target every cell type in every tissue, and control payload dosage/duration Check it out! programmable-genomics.github.io

My thoughts on connectomics and upload: 1) there is zero question connectomes are invaluable, and we need to get them for mouse, monkey, and human 2) the human, or even monkey, connectome seems a long ways off given costs (roughly $1/neuron). The projectome (map of all the axons) seems eminently reachable and should be a top priority imho 3) but even having the full connectome would only tell you numbers of synapses, not actual synaptic weights, and the two can be hugely divergent (eg only 5% of synapses onto V1 layer 4 neurons come from thalamus, even though this is the major driving input) 4) given #2 & #3, I think we can get to upload in the sense of building a functionally equivalent organism much faster through understanding the algorithms of the primate brain than through blind copying 5) in putting together something as complex as the human brain we would definitely want to check that the various pieces work as we go, which we can only do if we understand these pieces 6) I don't think upload in the sense of blindly creating a digital copy is the path to the abundant transhumanist future--actual understanding of brain structures so we can intelligently interface with them, and emulate their function in code without copying all the details, is. All to say, we need functional understanding to go hand in hand with anatomical mapping!

@FulkaLab @EwelinaBolcunF Keep digging and if you do find the reference, please share!

@ControllingLMNT @EwelinaBolcunF For sure. Successful maturation does not guarantee a "good" egg, and a euploid egg does not guarantee a viable embryo, right? Still don´t know where the reduced maturation rates in AMA oocytes I find in papers come from...

How does one identify an oocyte with good developmental potential? Contrary to the often-reported decrease in maturation rate with advancing age, we never observed any difference. Has anyone truly witnessed this, or is it just the result of pressure to meet expectations/publish?

Excited to share our new paper on #microproteins in @MolecularCell ! Thousands of non-canonical ORFs are translated across the genome, potentially encoding a vast “dark proteome” of uncharacterized proteins. But which ones are actually functional? authors.elsevier.com/a/1miua_OylrmL…

We have a fully-funded PhD studentship opportunity in my group to study primate-specific gene regulatory networks related to inflammation and DNA damage - please apply or send to promising candidates (UK Home fees eligible only), deadline is March 18th. kcl.ac.uk/study-legacy/f…

Tam, T.T.K.K., Xu, S., Li, Y. et al. Amniogenesis in embryos and stem cell models. Nat Cell Biol (2026). doi.org/10.1038/s41556…

Generation of functionally competent testicular somatic cells from pluripotent stem cells | Science Advances science.org/doi/10.1126/sc…

New online! Zscan4 enables the formation of the Z compartment dlvr.it/TR9wyf

Give their paper a read: nature.com/articles/s4159…

Excited to share our N&V: @NatureSMB rdcu.be/e5NR2 Check out the new nuclear compartment--dependent on Zscan4--that they term the "Z-compartment". Z-DNA exists under physiological conditions & how cells deal with this alternative DNA structure is just emerging!