Dudakov Lab

With a mix of pride, enthusiasm, and tremendous relief, I present our latest paper that describes the emergence of atypical epithelial cells in the thymus with age that limit the tissues function at steady-state and its repair after damage… 1/? nature.com/articles/s4159…

@Sutherland_TB If necessity is the mother of invention then justification is the father of imagination.

@Dudakov_Lab Still working out how I can justify this with my TB Research. Would love to be there. And not just because it's Hawaii....

[To the three scientists still left here]: Interested in T cells and where they come from? Then now is the perfect opportunity to register for ThymUS (thymusmeeting.org). Don't miss out on what is shaping up to be a fantastic meting in gorgeous Kauai.

#Immunology by First release now @ScienceMagazine Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection buff.ly/3DjNQ1e By @CicaCanesso, @victora_lab, @danmucida and colleagues.

Age-related decline in CD8+ tissue resident memory T cells compromises antitumor immunity @NatureAging nature.com/articles/s4358…

🚨Out now in @Nature: Our spatial atlas of the developing thymus nature.com/articles/s4158… Together with @Teichlab @MarioniLab and Germain lab we present insights into the establishment of the thymic organ structure in pre- and postnatal life through a new spatial mapping approach.

Specialized fibroblastic reticular cells underpin interconnected T cell environments with dedicated microenvironmental niches that promotes antitumor immunity in lung cancer @CellCellPress @ImmunobiologySG cell.com/cell/fulltext/…

Early-life thymectomy leads to an increase of granzyme-producing γδ T cells in children with congenital heart disease @SarinaRavens nature.com/articles/s4146…

New @CellCellPress resource: Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging cell.com/cell/fulltext/… Impressive dataset of aging associated transcriptomics alterations across multiple tissues that identifies immunoglobulin-associated senescence (IgGAS) as a marker of aging. Conducted using the @ST_Omics Stereo-seq platform.

Its great to be able to finally share our work identifying and examining CTLA4 expression by ILCs and its roles in regulating mucosal homeostasis! nature.com/articles/s4146…

New Review from @Muzz_Haniffa and colleagues @sangerinstitute explains how the prenatal immune system develops rdcu.be/dZcJn

This is one of the coolest data vis graphics I’ve ever seen.

Second place finishers in the @fredhutch Steamplant lab group costume contest for a second year running. Robbed.

Stem cell transplants are amazing. A patient's diseased blood is replaced by a relative or stranger's. But what does putting a blood system into a new body do to the cells? How many survive? Does it matter? Out in @Nature today, we asked some basic Qs 👇 rdcu.be/dYCoZ

Growing up in Australia I’ve always been uncommonly interested in US politics (even majored in it in undergrad) so it was an auspicious day to vote for the first time as an immigrant scientist in this country.

🎉Finally out! Many congrats to Savvas Savvidis, @RobertaRag80163 ,Valeria Conde de Rafael & all co-authors @ucl & @TheCrick for unraveling the human #thymus #development in #3D ! I am grateful for a fantastic experience @esrfsynchrotron in Grenoble nature.com/articles/s4385…

Are you the next team member to join us? More than your credentials, we are looking the right person! Both post-docs or PhD students are welcome. Come solve some fundamental issues of the human thymus biology with us! #recruiting #academicjobs #hiring #postdoc #phdcandidate

Online now!✨RESEARCH: Jing, Song and colleagues uncover METTL3 as a regulator of and potential target in thymic involution, where it regulates ferroptosis signaling nature.com/articles/s4358… rdcu.be/dXOEU

What a great opportunity! Eliisa is an amazing physician-scientist working on some very cool projects (and could quite possibly be even more of a thymus enthusiast as I am!).

Sex-based differences in thymus biology and T cell development arise before puberty, providing an essential contribution to our understanding of the mechanisms underlying immune function and dysfunction in males and females @Dev_Cell @PZandstra Rossi cell.com/developmental-…