Edy Kim

My reflections on how COVID put the "physician" into phys-scientist. Started my lab then left turn into open-access COVID clinical guidelines. For all of us, a formative time, but hard to say what form... elifesciences.org/articles/77184

Huge thanks to @waikarss, @EdyKim5, and @NIDDKgov, without whom this would not have been possible.

In a new study published in @ScienceTM, researchers from @BrighamAnes @MGHanesthesia and colleagues found new insights into preventing brain injury after cardiac arrest. Read more: massgeneralbrigham.org/en/about/newsr… @EdyKim5 @FumitoIchinose doi.org/10.1126/scitra…

Diverse natural killer T cells regulate innate immunity to improve neurological outcomes and survival after cardiac arrest @ScienceTM @EdyKim5 science.org/doi/10.1126/sc…

Moving to edykimlab.bsky.social

Our review paper led by Alene Saavedra, outlining several nuances that emerged for RA-ILD treatment in the recent ACR/CHEST guideline - in particular AZA and MMF We also review all trial evidence - only 3 RCTs (n=217 total!) have enrolled RA-ILD pts! link.springer.com/article/10.100…

Our latest study investigating risk factors for RA-ILD subtypes, led by Dr Gregory McDermott We systematically identified/subtyped all RA-ILD cases and RA-noILD controls in the @BrighamWomens RA Sequential Study and @MassGenBrigham Biobank (n=3328) acrjournals.onlinelibrary.wiley.com/doi/10.1002/ac…

Our latest one is out @Nature ! We found an aberrant immune epithelial progenitor niche drives post viral lung inflammation and fibrosis #LongCovid. We also pointed out potential therapeutics. nature.com/articles/s4158… Shout-out to @hnarasim23 and @wqian1016 @PeterChenMD @zangcz

High-throughput identification of functional regulatory SNPs in systemic lupus erythematosus - published now in @NatureComms @BrighamResearch nature.com/articles/s4146…

1. Introducing a new thread: super basic lung pathology for PGY1s, with arrows. If you are a PGY1, leave a comment and I will tag you in a future post. A hamartoma is a disorganized mix of overgrown normal tissues (in their normal location) that creates a mass. Good news: they are benign! #pathology #pulmpath #tweetorial #pathtweetorial #sblppgy1

@DrAnneCarpenter We ended up with Sciwheel--google doc and Word doc integration worked better than Zotero for us. Very easy to share sciwheel reference libraries by project.

We'd like to have a system to share papers within the lab, both PDFs and our comments about each paper. As people depart, they could take a copy of the whole 'library' with them. I'm going to check if Paperpile has nicer sharing these days, but any other ideas we should try?

Finally out today! Very proud of this story: Innate immune memory after Stroke drives remote organ pathology This study was led by superstar-postdoc @SimatsAlba and X-less Sijia Zhang. @CellCellPress cell.com/cell/fulltext/…

Have you wondered how Yamanaka found the 4-gene combination to transform somatic cells to stem cells? The # of possibilities are greater than - 20,000^4. I did this yesterday & read the original paper. What a journey & pure joy it was! Here’s how he did it. ⌛️

Collab led by Mari Kamiya (Kim lab), Hogaboam lab, Beth Moore lab, @leticiakawano, Joyce Lee (CU), @FanZhang_Jessie, @jeffsparks, Chip Merriam, co-senior @wm_oldham also of @BWHPulmCCM @BrighamResearch. 7/7

In conclusion we echo the call of many others for translational insight into the natural history of lung fibrosis: earliest stages, acute exacerbations and integration of genomics with immunophenotyping (and mechanism!). 6/7

Our review of immune axes in lung fibrosis @CellCellPress is for the immunologist or cell biologist without a clinical background but reflects our lab's physician-scientist approach. 1/7.

I highly recommend this leadership & management training program for postdocs & junior faculty!