Leeds Integrative Membrane Biology

@LeedsIMB

An interdisciplinary research theme in the School of Biomedical Sciences at the University of Leeds, focussing on membrane proteins in health and biotechnology.

Leeds, U.K. Beigetreten Eylül 2019

22 Folgt100 Follower

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Pliotas Group@PliotasGroup·5 Oca

In our latest article we found structural correlation between pocket modification and tension activation in the MscL channel using pulsed EPR, HDX and MD: cell.com/structure/full… @Bolin83814396 @95bjl @anton_calabrese @FrankSobott @KalliGroup @EPR_ESR @RSC_ESR @AstburyCentre

Anton Calabrese@anton_calabrese

Really pleased to see this online today in @Structure_CP - fantastic work led by @Bolin83814396 @95bjl @PliotasGroup on the role of lipids and membrane tension in modulating the mechanosensitive ion channel MscL @KalliGroup @MassSpecLeeds @AstburyCentre sciencedirect.com/science/articl…

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Pliotas Group@PliotasGroup·1 Nis

Check out our new preprint: Mechanical and molecular activation lead to structurally analogous MscL states biorxiv.org/content/10.110… Great effort by @Bolin83814396 & @95bjl, @FrankSobott @anton_calabrese @KalliGroup at @AstburyCentre @ScienceLeeds @LeedsIMB @MassSpecLeeds

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Stephen Muench@stemuench·26 Oca

Took a while to get around the preferred orientation of HSPD1 but good to see the hard work of @DavidKlebl and the team @MatthewFeasey @HeskethEmma @RSBon_Lab @naranson @FrankSobott finally out. cell.com/iscience/fullt…

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Jannik Strx@Jannik_Strx·16 Eyl

So excited to see IMPROvER finally published!!! First first authorship together with @Steve_Harborne and @JessicaJCB_ 🍾 Give it a go and stabilise your most loved/hated membrane protein :) nature.com/articles/s4159…

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Biophysical Journal@BiophysJ·30 Tem

#OPENACCESS: "In-Lipid Structure of Pressure-Sensitive Domains Hints Mechanosensitive Channel Functional Diversity" by Charalampos Kapsalis et. al. cell.com/biophysj/fullt… @PliotasGroup @Bela_Bode @mayue3691 @LeedsIMB @AstburyCentre @ScienceLeeds @StAndrewsBSRC

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Stephen Muench@stemuench·16 May

It started out as a 10 week rotation project looking at particle behaviour in the ice, over 1 year later we finished it! Thanks to lots of people @DavidKlebl @Bex_16 @MDarrow7 @Molly_Gravett @michkouros @DCFMonteiro and more.. biorxiv.org/content/10.110…

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Jon Lippiat@DrJonLippiat·25 Nis

It's published! #ionchannels #kcnt1 #epilepsy @Beth_aimee_cole @RachelJ9908 @jeff_dddd @FishwickGroup @stemuench

iScience journal@iScience_CP

Structure based identification and characterisation of inhibitors of the epilepsy associated KNa1.1 (KCNT1) potassium channel cell.com/iscience/fullt…

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Robin Bon@RSBon_Lab·18 Nis

Very proud to share the first #CryoEM studies by our @UoL_LICAMM @AstburyCentre #TRPC team: Cryo-EM structures of human TRPC5 reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site. biorxiv.org/content/10.110…

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Goldman Lab@GoldmanLab·6 Oca

We’ve got an exciting #postdoc opportunity working on #membraneprotein #structuralbiology in close collaboration with @LarsJeuken @PliotasGroup and Dr Antreas Kalli! Check it out here and please encourage anyone that could be interested to apply: jobs.leeds.ac.uk/vacancy.aspx?r…

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