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Steven Harborne
204 posts
Steven Harborne
@Steve_Harborne
Biochemistry, bikes and brewing!
Manchester, England Katılım Aralık 2014
265 Takip Edilen152 Takipçiler
Steven Harborne retweetledi
Join #EMBOPEPC to learn how to troubleshoot in the wet lab during solubilisation and reconstitution, and how to conduct experiments at the beamlines and during early stages of cryoEM screening. 🔎⚡️
✍️ Apply by 17 June
📍 EMBL Hamburg
➡️ s.embl.org/pep24-01
🔸 Speakers and Trainers
Lucia Banci, University of Florence
Clement Blanchet, @EMBLHamburg
@Osvalburastero, EMBL Hamburg
@LucasADefelipe, EMBL Hamburg
Juan Du, @VAInstitute
Jens Frauenfeld, @SaliproBiotech
@MelissaPoynor, EMBL Hamburg
@Steve_Harborne, @PeakProteins
@ProfSyK, @UniofOxford
@jankosinski, EMBL Hamburg
@kirkovalev94, EMBL Hamburg
@linamalinama1, @VU_LT
@MarlovitsLab, @UKEHamburg and @CssbHamburg
@Mel_McDowell22, @MPIbp
Pedram Mehrabi,@MPSDHamburg
@stemuench, @UniversityLeeds
Stephan Niebling, EMBL Hamburg
Arwen Pearson, @unihh and @MPSDHamburg
Martin Pelosse, @EMBLGrenoble
@KimRemans, EMBL Heidelberg
Mikhail Savitski, EMBL Heidelberg
Eike Schulz, @UKEHamburg
Markus Seeger, @seegerlab, @UZH_en
@BettinaSiebers, University of Duisburg-Essen
Henning Tidow, @unihh
Maya Topf, Centre for @CssbHamburg and @LeibnizLIV
Charlotte Uetrecht, @uetrechtlab, @CssbHamburgy and @LeibnizLIV
Katharina Veith, EMBL Hamburg
David von Stetten, EMBL Hamburg
Yexin Xie, @EMBLHamburg
🔸 Scientific Organisers
Maria Garcia, EMBL Hamburg
Simon Mortensen, EMBL Hamburg
Kim Remans, EMBL Heidelberg
Angelica Struve, EMBL Hamburg
Henning Tidow, @unihh
#membraneproteins #structuralbiology #cryoem #saxs #macromolecularcrystallography #crystallography #biophysicalcharacterisation #cellbiology #spectrometry #xraydiffraction #enzymaticreactions #proteinmodelling
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Steven Harborne retweetledi
Yesterday was #InternationalLegoDay, so we wanted to share this fantastic LEGO diorama of our I24 beamline made by @PeakProteins last year! 🧱⬇
Read more about I24 here: diamond.ac.uk/Instruments/Mx…
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 20. Synchrotrons and Structural Determination. We use Synchrotrons like the one at @DiamondLightSou to solve protein structure. This model is a diorama of the i24 beamline.
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 23.
Counting Cells at Peak Proteins with the @BCILifeSciences Vi-CELL. Using this at Peak Proteins has allowed increased capacity in the cell expression team, and enabled more small scale optimisation experiments to be performed.
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 22. Peak Proteins and IniXium - stronger together Following Sygnature Discovery 's acquisition of NuChem Sciences we are delighted to combine Inixium and Peak Proteins into one Protein Science and Structural Biology division.
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 22.
Peak Proteins and IniXium - stronger together
Following Sygnature Discovery 's acquisition of NuChem Sciences we are delighted to combine Inixium and Peak Proteins into one Protein Science and Structural Biology division.
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 21. Protein Purification at Peak Proteins (part of Sygnature Discovery). High quality protein purification is the backbone of what we do at Peak Proteins and the workhorses of this are our @Cytiva AKTAs.
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 21.
Protein Purification at Peak Proteins (part of Sygnature Discovery).
High quality protein purification is the backbone of what we do at Peak Proteins and the workhorses of this are our @Cytiva AKTAs.
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 20. Synchrotrons and Structural Determination. We use Synchrotrons like the one at @DiamondLightSou to solve protein structure. This model is a diorama of the i24 beamline.
English
Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 20.
Synchrotrons and Structural Determination.
We use Synchrotrons like the one at @DiamondLightSou to solve protein structure. This model is a diorama of the i24 beamline.
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 19. At Peak Proteins, we leverage cloud-based computing strategies through Amazon Web Services (AWS) to enhance efficiency and scalability in our structural data processing.
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 19.
At Peak Proteins, we leverage cloud-based computing strategies through Amazon Web Services (AWS) to enhance efficiency and scalability in our structural data processing.
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 18. Kifunensine and X-ray crystallography 🫱🏽🫲🏽 A common technique we employ at Peak Proteins is to grow cells in the presence of kifunensine then treat with Endo H to enhancing crystallisation.
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 18.
Kifunensine and X-ray crystallography 🫱🏽🫲🏽
A common technique we employ at Peak Proteins is to grow cells in the presence of kifunensine then treat with Endo H to enhancing crystallisation.
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 17. As part of our Cryo-EM workflow we offer the option of preparing negative stain grids & analysing them under a Transmission Electron Microscope. Here we assess the protein particle quality and suitability for proceeding to Cryo-EM.
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 17.
As part of our Cryo-EM workflow we offer the option of preparing negative stain grids & analysing them under a Transmission Electron Microscope. Here we assess the protein particle quality and suitability for proceeding to Cryo-EM.
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 16. We can produce high quality protein, tailor-made for SPR. As part of Sygnature Discovery we use SPR for hit identification, orthogonal hit confirmation and hit-to-lead activities. This model depicts antibody binding to an SPR chip.
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 16.
We can produce high quality protein, tailor-made for SPR. As part of Sygnature Discovery we use SPR for hit identification, orthogonal hit confirmation and hit-to-lead activities.
This model depicts antibody binding to an SPR chip.
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 15. Protein Structure Determination at Peak Proteins (part of Sygnature Discovery). This structure is ATP synthase which catalyses the formation of the energy storage molecule adenosine triphosphate (ATP).
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 15.
Protein Structure Determination at Peak Proteins (part of Sygnature Discovery).
This structure is ATP synthase which catalyses the formation of the energy storage molecule adenosine triphosphate (ATP).
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 14. NMR at Peak Proteins (part of Sygnature Discovery). We’re very excited to be offering NMR data collection and interpretation for our clients and have a number of projects underway. 🙌🏽🧲
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 14.
NMR at Peak Proteins (part of Sygnature Discovery).
We’re very excited to be offering NMR data collection and interpretation for our clients and have a number of projects underway. 🙌🏽🧲
Peak Proteins@PeakProteins
Building' up to the Holiday Season - Day 13. We regularly produce protein for SPR. This can be for direct client use or we can perform SPR in-house - Sygnature discovery has extensive SPR capabilities and multiple @Cytiva Biacore systems.
English
Steven Harborne retweetledi
Building' up to the Holiday Season - Day 13.
We regularly produce protein for SPR. This can be for direct client use or we can perform SPR in-house - Sygnature discovery has extensive SPR capabilities and multiple @Cytiva Biacore systems.
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 12. Cryo-EM at Peak Proteins (part of Sygnature Discovery). We are pleased to now be offering Cryo-EM alongside our other protein structure services (X-ray Crystallography and NMR).
English
Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 12.
Cryo-EM at Peak Proteins (part of Sygnature Discovery). We are pleased to now be offering Cryo-EM alongside our other protein structure services (X-ray Crystallography and NMR).
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 11. Expression optimisation at Peak Proteins (part of Sygnature Discovery). We recently applied Design of Experiments (Doe) towards optimising expression from our mammalian HEK293 6E cells. 📖 Read more lnkd.in/edut_ibu
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 11.
Expression optimisation at Peak Proteins (part of Sygnature Discovery). We recently applied Design of Experiments (Doe) towards optimising expression from our mammalian HEK293 6E cells.
📖 Read more
lnkd.in/edut_ibu
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 10. Cell Science at Peak Proteins (part of Sygnature Discovery). At Peak Proteins we can express proteins from a number of different cell types. Last year we introduced expression from CHO cells. lnkd.in/e7QnKFJX.
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 10.
Cell Science at Peak Proteins (part of Sygnature Discovery). At Peak Proteins we can express proteins from a number of different cell types. Last year we introduced expression from CHO cells. lnkd.in/e7QnKFJX.
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 9. Antibodies at Peak Proteins (part of @SygnatureDiscov ). We have supported many antibody development projects including: ➡️ Multispecifics ➡️ ADCs ➡️ T-cell engagers ➡️ Fc fusions ➡️ Antibody fragments
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 9.
Antibodies at Peak Proteins (part of @SygnatureDiscov ).
We have supported many antibody development projects including:
➡️ Multispecifics
➡️ ADCs
➡️ T-cell engagers
➡️ Fc fusions
➡️ Antibody fragments
Peak Proteins@PeakProteins
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 7.
At Peak Proteins (part of @SygnatureDiscov ) we have extensive Protein Crystallography capabilities. This is driven by our investment in specialised crystallography robotics including @SPTLabtech 's Mosquito.
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 6. Protein Expression and Purification at Peak Proteins (part of @SygnatureDiscov ). At Peak Proteins we can express and purify proteins from E. coli, insect and mammalian cells. lnkd.in/d5Qa27t7
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Steven Harborne retweetledi
'Building' up to the Holiday Season - Day 6.
Protein Expression and Purification at Peak Proteins (part of @SygnatureDiscov ). At Peak Proteins we can express and purify proteins from E. coli, insect and mammalian cells.
lnkd.in/d5Qa27t7
Peak Proteins@PeakProteins
Day. 5 'Building' up to the Holiday Season - Day 5. Mass Spectrometry at Peak Proteins (part of Sygnature Discovery). In addition to part of our QC, we offer Mass Spectrometry as a standalone service. Find out more lnkd.in/d4GittbV
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Steven Harborne retweetledi
Day. 5
'Building' up to the Holiday Season - Day 5.
Mass Spectrometry at Peak Proteins (part of Sygnature Discovery). In addition to part of our QC, we offer Mass Spectrometry as a standalone service.
Find out more
lnkd.in/d4GittbV
Peak Proteins@PeakProteins
'Building' up to the Holiday Season - Day 4. At Peak Proteins we use the Fida 1 platform from @FIDATechnology for a number of our client projects. 📖Read more about how we use Fidabio lnkd.in/eKy28Q_4
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