Yen-Der Li

RTW Investments recently hosted our RTW Intern Alumni Night! Current interns had the opportunity to relax, network, and hear from accomplished alums who shared their experiences and career insights.

A new paper from Benjamin Ebert, Nathanael Gray, @eric_fischer, @fischerlab1, @LiYender, Michelle Ma, and @M_MurtazaHassan reports a trans-labeling mechanism “template-assisted covalent modification”, which enables proximity-driven pharmacology rdcu.be/dPzUW

Congratulations to ALL 2023 Graduates! @HarvardGSAS @HasreetGill @anuraglimdi @GalLumbroso @KalkiKukreja @min_jiseon @Ju_Brr @sylviahurlimann @KumareshSpikes @LiYender mcb.harvard.edu/department/new…

DCAF16-focused seminars are now available online: youtube.com/watch?v=hri_Rz… youtube.com/watch?v=mRuiNR…

1/8 💡🦠 Can we harness human E3 ligases for antiviral defense? Are human E3 ligases involved in maintaining SARS-CoV-2 virus stability? Our pandemic research project is finally published! #COVID19 #E3Ligase cell.com/iscience/fullt…

Join for DCAF16-focused seminars: Yen-Der Li @LiYender (Ebert Lab), Michelle Ma (@fischerlab1), and Muhammad Murtaza Hassan @M_MurtazaHassan (Gray lab). As well as Matthias Hinterndorfer @_matthias_h (@georg_e_winter), Ollie Hsia @ollie_lh, and Angus Cowan (@alessiociulli lab)

1/9 What happens when covalent chemistry meets molecular glue? The Ebert Lab, @fischerlab1, and Gray Lab discovered a trans-labeling covalent mechanism we termed “template-assisted covalent modification” from a new class of DCAF16-based BRD4 degraders.biorxiv.org/content/10.110…

A study by @genentech with huge implications for #TPD & #PROTAC space (efficacy & safety): Induced degradation of certain proteins generates peptides which bind to & induce cIAP1 autodegradation, leading to caspase activation & cell death. @biorxivpreprint biorxiv.org/content/10.110…

Gene therapy landscape I pulled together 42 public companies and charted the preclinical & clinical assets of each, segmented by approach & vector Some takeaways:

Great paper by the group of @georg_e_winter in @J_A_C_S. They establish a luciferase-based screening platform that allows the systematic identification of new E3 ligases amenable to molecular glue design as well as their degradation targets. doi.org/10.1021/jacs.2…

A very informative read! Protein–protein interfaces in molecular glue-induced ternary complexes: classification, characterization, and prediction Drs. Jaeki Min P. Ryan Potts, Ph.D. Congratulations! lnkd.in/gWFQidGw lnkd.in/gSPrKTHz

I've always been somewhat skeptical about bifunctional modalities due to their "expected" poor PK/PD, but many molecules surprised me with their superior efficacy despite their bizarre shape, and now we got some clues - groundbreaking work from @kevansf science.org/doi/10.1126/sc…

How cool is that? New paper @Nature, E3 #ubiquitin ligases keep on giving #Proteindegraders #PROTACs nature.com/articles/s4158…

6/11. This point was emphasized in research from Haian Fu's lab at Emory where missense oncogenic alleles were found to alter interactomes frequently. cell.com/cell/fulltext/…

It is our sincere pleasure to reveal that Professor Benjamin F. Cravatt III of @ScrippsRTI is one of the 2022 #Wolf Prize laureates in Chemistry.

Excited to present our work on how cells detect the deleterious absence of reactive oxygen species, or reductive stress. Meet a very small #molecularglue for a #ubiquitin ligase and a new regulator of #mitochondria. (1/n) cell.com/cell/fulltext/…

This is legit, out of the world.