Fischer Lab

279 posts

Fischer Lab

@fischerlab1

Boston, MA Beigetreten Mayıs 2018

53 Folgt2K Follower

Fischer Lab retweetet

Katherine A Donovan@kdonovan1008·24 Tem

🧩 New paper out in Nature Communications! "Unveiling the hidden interactome of CRBN molecular glues" Huge thanks to our incredible team and collaborators who made this possible! 📖 Read the full open-access article here: nature.com/articles/s4146…

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Michael Erb@Michael_A_Erb·1 Eki

We keep stumbling on molecular glues, but how can they be made for a pre-selected target? We’ve been working on this question, envisioning a high-throughput chemistry (HTC)-based approach to convert pre-existing ligands into molecular glues. biorxiv.org/content/10.110…

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Michael Erb@Michael_A_Erb·1 Eki

This project was led by postdoc Jamie Shaum and assisted by so many friends (to whom we are most grateful): @georg_e_winter, @fischerlab1, @alessiociulli, @Armstrong_dfci, @alessiociulli, Seiya Kitamura, @brumelillo, @EngleLab, and Ben Cravatt. (8/end)

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Nature Chemical Biology@nchembio·31 Tem

A new paper from Benjamin Ebert, Nathanael Gray, @eric_fischer, @fischerlab1, @LiYender, Michelle Ma, and @M_MurtazaHassan reports a trans-labeling mechanism “template-assisted covalent modification”, which enables proximity-driven pharmacology rdcu.be/dPzUW

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Jiho Park@jihojasonpark·23 Tem

Tune in for a polymerization-themed doubleheader from me, Paul, and @MSuskiewicz this Thursday at 11am EDT!

Zuzanna Kozicka@zkozicka

Exciting double #polymerisation seminars this week! Join us on Thursday, July 25th at 11 am EDT to hear the duo of @jihojasonpark and Paul Park from @DanaFarber as well as @MSuskiewicz from @CNRS talk about homomerising transcription factors. 👉 bit.ly/3OmMRjp

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Jiho Park@jihojasonpark·12 Tem

Excited to share our story on polymerization in ZBTB transcription factors, which was published in the July 11 issue of @MolecularCell! cell.com/molecular-cell… 1/n

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Dana-Farber Cancer Biology Department@DFCI_CancerBio·10 Tem

Nice DFCI Insight blog post about Sidney Farber Fellow @FranziskaWacht1 who will be conducting her research in @fischerlab1 blog.dana-farber.org/insight/2024/0…

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Katherine A Donovan@kdonovan1008·18 Nis

We are looking for a couple of Research Technicians to join us in the @fischerlab1! If you enjoy biochemistry/chem bio and are interested in working in a great team exploring degrader induced interactions and degradation reach out or apply: careers.dana-farber.org/job/research-t… Please RT!

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Radek Nowak@RPNowak·7 Nis

#AlphaFold can accurately predict PP2A complexes! We solve the structure of #PP2A A R5E C complex and show that PP2A phosphatase assembly is independent of the C subunit methylation. Great team with amazing @FranziskaWacht1 @fischerlab1 #Xray jbc.org/article/S0021-…

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Fischer Lab@fischerlab1·5 Nis

Congratulations @FranziskaWacht1 🎉👏

Dana-Farber Cancer Biology Department@DFCI_CancerBio

Congratulations @FranziskaWacht1 in @fischerlab1 for receiving the 2024 Sidney Farber Scholar Award!!

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The Roberts Lab@TheRobertsLab1·27 Mar

Just in time for #HumpDay: Our study Targeting DCAF5 suppresses #SMARCB1-mutant #cancer via stabilizing SWI/SNF is online now in @Nature. Congratulations 🎉 to co-first authors Sandi-Radko-Juettner and @HongYue88665668 and all co-authors on this story! 1/ nature.com/articles/s4158…

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Hubert Huang@hai_tsang_huang·21 Mar

Excited to share E3-substrate tagging by ubiquitin biotinylation (E-STUB) @nchembio! E-STUB enables CUL-RING ligase substrate identification and may transform the way we study glues and PROTACs by directly studying substrate ubiquitylation. 1/ rdcu.be/dBZKx

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Fischer Lab@fischerlab1·20 Mar

Congratulations @KheewoongBaek 👏🎉

Damon Runyon Cancer Research Foundation@DamonRunyon

We are delighted to welcome a new class of Damon Runyon Fellows! Learn more about these talented researchers and the questions they'll work to answer as Damon Runyon scientists: damonrunyon.org/news/entries/7…

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Fischer Lab@fischerlab1·15 Mar

Great to see this story out - congrats to the team 🎉

David R. Liu@davidrliu

Today in @Science_Magazine we report the laboratory evolution of compact degrons that enable targeted protein degradation triggered by an otherwise-inert small molecule, a multidisciplinary study that integrates organic chemistry, molecular glues, protein evolution, genome editing, and structural biology. PDF: drive.google.com/file/d/18hu15h… 1/13

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Lyn Jones@LynJonesChemBio·15 Mar

We are looking for a postdoctoral research fellow to work with Eric Fischer and myself to pioneer next-generation covalent drug discovery. Please retweet. Apply here: careers.dana-farber.org/jobs/?search_t… @fischerlab1

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Fischer Lab@fischerlab1·10 Kas

Another incredibly fun @HMS_BCMP retreat - we decided to become the UPS this year!!

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Radek Nowak@RPNowak·3 Kas

NEWS! I'm excited to share that I'm joining @IsbBonn @UniklinikBonn @UniBonn @ImmunoSens as a professor to start my LAB! We are open for business and #hiring for #postdoc #tech positions! #NewPI #MoveToGermany #UniBonn #TPD #InducedProximity Please share! nowak-lab.com

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Fischer Lab@fischerlab1·20 Eki

Don’t miss out on attending the Keystone Targeted Protein Degradation and Proximity Therapeutics, January 21-24, 2024 🧬⛷️👩‍💻 Abstract deadline is October 26. Targeted Protein Degradation lnkd.in/erkd5Yt4 Proximity Based Therapeutics lnkd.in/evkF59ga

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Katherine A Donovan@kdonovan1008·2 Eki

This week in the TPD seminars we are hosting two excellent speakers @KheewoongBaek and @LukasHenneberg sharing stories from work completed in Prof. Brenda Schulman's lab at Max Planck Institute for Biochemistry ! See you at 11am EST!!!

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Katherine A Donovan@kdonovan1008·2 Eyl

We have exciting new updates to our schedule for the free TPD in-person event on September 14th! Register on our webpage and see you soon!!

Mikołaj Słabicki@biomiko

Check out our final program for TPD Hybrid Meeting, on September 14th, 12-7pm, The event features seminars, panels, flash talks, and networking opportunities. …afarbertargetedproteindegradation.org

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Entdecken

@alessiociulli @Armstrong_dfci @brumelillo @EngleLab @eric_fischer @LiYender @M_MurtazaHassan @MSuskiewicz