Mordes Lab

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Mordes Lab

Mordes Lab

@MordesLab

Integrating neuropathology, stem cells, and multi-omics to study neurodegeneration #ALS #dementia @UCSFPath @INDUCSF 🧠🔬🌻

San Francisco, CA Beigetreten Şubat 2022
143 Folgt145 Follower
Mordes Lab
Mordes Lab@MordesLab·
Excited to share our @CellReports article! We investigated how the loss of TBK1 function contributes to ALS and dementia using human stem cell-derived neurons and advanced proteomics. Many thanks to all co-authors for their great work and collaboration! sciencedirect.com/science/articl…
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ShorterLab
ShorterLab@ShorterLab·
Regulation of translation elongation and integrated stress response in heat-shocked neurons: Cell Reports cell.com/cell-reports/f…
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ShorterLab
ShorterLab@ShorterLab·
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing: nature.com/articles/s4146…
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Nowakowski_Lab
Nowakowski_Lab@LabNowakowski·
Excited to share new study from the lab, work led by @JohnPAndrews_MD and grateful for all the collaborators who made this possible including @ChangLabUcsf @ucscgenomics
UCSF Neurosurgery@NeurosurgUCSF

Today in @NatureNeuro, researchers led by @LabNowakowski, @ChangLabUCSF & Mircea Teodorescu (@ucscgenomics) demonstrate the first use of optogenetics to modulate seizure activity at the network level in human brain tissue: nature.com/articles/s4159… @JohnPAndrews_MD @UCSFstemcell

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Rothstein Lab
Rothstein Lab@Rothstein_Lab·
Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes cell.com/neuron/fulltex…
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Mordes Lab
Mordes Lab@MordesLab·
Had a great time at the Oktoberfest IND collaboration hour! Thanks to everyone who stopped by.
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Mordes Lab@MordesLab·
Excited to announce new funding from the NIA to investigate the connection between defects in protein homeostasis and neurodegeneration. #FTD #dementia #ALS
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Mordes Lab@MordesLab·
Had a lot of fun at lab lunch! Welcome to the lab, Nicole and Lisa!
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Target ALS
Target ALS@TargetALS_fdn·
The Target ALS #DataEngine just got bigger! We’ve expanded datasets across all core collections, added a user manual, and released new demo videos. Now it’s easier than ever to explore and utilize rich data for #ALSResearch. Explore the updates: bit.ly/3yVk2GF
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Vik Khurana Lab
Vik Khurana Lab@khurana_lab·
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions: Neuron cell.com/neuron/fulltex…
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Francesco Limone
Francesco Limone@ScienceLemon92·
Excited to finally share work from a past life! In this small study we dissect neuronal vulnerability, myelin dysfunction and microglia activation in #ALS read our full work on @NatureAging nature.com/articles/s4358…
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Jennifer Yokoyama
Jennifer Yokoyama@YokoyamaLabUCSF·
Check out the data that goes along with our new manuscript & conduct an exciting secondary analysis of your own! @RCFNeuro @alzdemjournals
Alzheimer's Disease Data Initiative@AlzData

New data from the @YokoyamaLabUCSF and @UCSFmac is now available on AD Workbench. Researchers can use this dataset to identify novel disease associations, cell-specific impacts, and therapeutic targets for Alzheimer’s. Access data via AD Workbench: bit.ly/45C3zmA

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Martin Kampmann
Martin Kampmann@MartinUCSF·
Excited to share this review on one of my favorite biological problems: Selective vulnerability in neurodegenerative disease, and how recent technologies are yielding new insights into the underlying mechanisms. Out in @NatRevNeurosci today! nature.com/articles/s4158…
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Mordes Lab
Mordes Lab@MordesLab·
Exciting study from the Gitler Lab: TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes biorxiv.org/content/10.110…
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Institute for Neurodegenerative Diseases
Are you an incoming UCSF grad student interested in doing research in neurodegeneration? If you are, join us at the IND OPEN HOUSE @ Helen Diller on 11/15 to meet our current trainees and faculty and to discuss their research! Register here: forms.gle/sqTX5GLNoHiGym…
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