Paul Garrity
770 posts
Paul Garrity
@Nemvec
Prof. Biology, Brandeis. We study how flies/mosquitoes sense. Grateful to be part of @BrandeisMCB and @BrandeisNeuro. (R. Busby (logo) & C. Zhu).
Boston Beigetreten Nisan 2010
173 Folgt897 Follower
@FedExHelp Fedex driver pulled up outside our house, then drove off without exiting vehicle. We were there/opened door. 30 min later app says we were "unavailable". Called CS, they claimed we had called to call off delivery at our house (which we had not). We are concerned.
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I will be happy to check on your package. Please DM your name, complete address, tracking number, phone number, and email address. twitter.com/messages/compo…
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Paul Garrity retweetet
Attending ASCB|EMBO? Join us for a Special Interest Subgroup on Sensory Receptors, featuring @EGouaux15625 @RachelleGaudet Maude Baldwin @MPIforBI Juan Du @DuLuLabs @CoreyAHAllard and Eric Mulhall, co-organized with Paul Garrity @Nemvec @ASCBiology @EMBO #cellbio2024
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Congrats! You rock!!! I will share this with my #Bio4500 neurobiology students #BrainyTigers
Paul Garrity@Nemvec
How do mosquitoes find people to bite & places to lay eggs? Turns out, sensing water vapor is key. In new work we (Tang et al.) ID mosquito receptors for dry/moist air. KO'ing them drops blood feeding and renders females unable to find water to lay eggs. pnas.org/doi/10.1073/pn…
Missouri, USA 🇺🇸 English
How do mosquitoes find people to bite & places to lay eggs? Turns out, sensing water vapor is key. In new work we (Tang et al.) ID mosquito receptors for dry/moist air. KO'ing them drops blood feeding and renders females unable to find water to lay eggs. pnas.org/doi/10.1073/pn…
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Paul Garrity retweetet
Paul Garrity retweetet
My autobiography is now published on the @NobelPrize website. It covers both my personal and professional life, highlighting the decisions and events that have had the biggest impact. I appreciate the opportunity to tell my story. Hope you enjoy reading it
nobelprize.org/prizes/medicin…
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Paul Garrity retweetet
Sugar detection in 3D: Structure of an insect gustatory receptor dlvr.it/T6K3Fs
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Now out in final form: Structural basis of ligand specificity and channel activation in an insect gustatory receptor (w/ our collaborators in the Gaudet lab)
cell.com/cell-reports/f…
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Paul Garrity retweetet
Friday's retreat of the Center for Molecular Investigation of Neurological Disorders brought together neuroscientists and related researchers from UP and @PennStHershey with guests like keynote speaker @Nemvec.
See all the pics on our Flickr album: flic.kr/s/aHBqjBkHiL
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Sad news: John DeModena, long-time tech w/@wormraiserand friend to so many of us, has passed. Demo’s generosity of spirit and enthusiasm for life were inspiring. There will be a celebration of Demo’s life 1/27 in the Morgan library
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Preprint: Structure of an insect gustatory receptor. Heather Frank, Sanket Walujkar, Richard Walsh, Willem Laursen, Doug Theobald, me and Rachelle Gaudet. Collaborative effort 5 years in the making! biorxiv.org/content/10.110… 1/4
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@Goodflies Thanks Bing. Grateful to get to participate alongside people like Rachelle, Heather, Sanket, Richard, Doug and Willem. Have been wanting to know better what these things meant since the days of Gr28b!
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You rock! Congratulations
Paul Garrity@Nemvec
For GR fans: Signature motif residues (TYhhhhhQF) make specific contributions to pore helix: T helps form hydrophilic path; Y binds lipid head group; QF gates pore entrance. Also new: intersubunit fenestrations of both GRs and ORs are inhabited by pore-penetrating lipids. 4/4
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For GR fans: Signature motif residues (TYhhhhhQF) make specific contributions to pore helix: T helps form hydrophilic path; Y binds lipid head group; QF gates pore entrance. Also new: intersubunit fenestrations of both GRs and ORs are inhabited by pore-penetrating lipids. 4/4
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Take homes: Unlike known ORs, Gr9’s ligand-binding pocket is larger, solvent accessible and heavy on polar/aromatics. Using structure-based alignments and alphaFold, we leverage this to examine structural and chemical properties of GRs more broadly. 3/4
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Paul Garrity retweetet
We are back to business! The very first in vivo voltage imaging in Huang lab. Look at how this neuron changes firing mode. This simplistic voltage scope only costs ~$50k, mostly @Thorlabs parts. Let me know if you want a full part-list to build your own one.
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