samyounglab

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samyounglab

samyounglab

@SamYoungLab

Deciphering cellular and molecular mechanisms of synaptic function and impact on neuronal circuit output. Viral vector development and CNS gene therapy.

Iowa City, IA Beigetreten Aralık 2018
491 Folgt862 Follower
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Lu-Yang Wang
Lu-Yang Wang@SynapticTweeter·
Delighted to share our new Nature paper: rdcu.be/dNlMQ This works shows a surprising off-target effect of glutamate on another cell death channel, acid sensing ion channels (ASICs). It turns out that glutamate directly binds to ASICs as a positive allosteric modulator
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Matt Hill
Matt Hill@canna_brain·
So for those of you interested in what it was that I took issue with in Hubermans first cannabis podcast, this is the Coles notes of the errors/inaccuracies that I noted. A lot of this is covered in the new episode, but some wont make it through and for others this is the TLDR
Andrew D. Huberman, Ph.D.@hubermanlab

New Huberman Lab podcast out now: CANNABIS: EFFECTS ON HEALTH & RISKS w/guest @canna_brain •THC, CBD Biology •Cannabis & Psychosis •Is THC addictive? •Are Strain Differences Real or Placebo? •Appetite, Hormones •Dosage Control: Inhaled vs Edible hubermanlab.com/episode/dr-mat…

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samyounglab
samyounglab@SamYoungLab·
Love cellular and molecular neuro. We are hiring a staff scientist interested in building framework of molecular principles for accurate sound information encoding and contribution to auditory deficits. unc.peopleadmin.com/hr/postings/28… Must have background in patch clamp DM or email
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samyounglab@SamYoungLab·
Big news. We are moving. I have officially started as the Director of the Gene Therapy Center, and as a Professor of Pediatrics and Professor of Pharmacology at UNC-Chapel Hill. I am returning “home” to lead the Center where I earned my PhD.
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samyounglab@SamYoungLab·
@UIowaACB I will always treasure my time in the Department and at the U. Amazing colleagues and research environment. It is extremely difficult to say goodbye. Once a Hawkeye always a Hawkeye.
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UIowa - Department of Anatomy & Cell Biology
UIowa - Department of Anatomy & Cell Biology@UIowaACB·
Last night, we celebrated @SamYoungLab who will be leaving at the end of the month to start his new position as the Gene Therapy Center Director at the University of North Carolina, Chapel Hill. Sam, your one-of-a-kind personality will be deeply missed!!
UIowa - Department of Anatomy & Cell Biology tweet mediaUIowa - Department of Anatomy & Cell Biology tweet mediaUIowa - Department of Anatomy & Cell Biology tweet media
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Deniz Atasoy
Deniz Atasoy@AtasoyLab·
I just received the official provost letter for promotion to Associate Professor with tenure. I owe many thanks to amazing lab members, colleagues and mentors who have continuously supported me.
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samyounglab@SamYoungLab·
@Wessel_Lab Lift heavy weight Squats deadlifts and bench press
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Jan Wessel
Jan Wessel@Wessel_Lab·
Turning 40 in a few months. What did you guys do for your midlife crisis? Not really into cars and already familiar with The National.
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samyounglab@SamYoungLab·
@cacna1a Thankyou for all your support in making this research happen!
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CACNA1A Foundation
CACNA1A Foundation@cacna1a·
Congratulations @SamYoungLab on your incredible work to change the gene therapy landscape for CACNA1A-related disorders and other cerebellar diseases! We are proud to have supported your team on these efforts. #CureCACNA1A
samyounglab@SamYoungLab

For ~25 years Ad vectors had little to no ability to transduce Purkinje cells, until now! Excited to announce our paper in MTMCD @MolTherapy on the development of Ad vectors that transduce Purkinje cells in a humanized mouse model shorturl.at/wyBW5

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CACNA1A Foundation
CACNA1A Foundation@cacna1a·
Congratulations @SamYoungLab on being awarded Team #CACNA1A @MDBRide4Rare grant for “Development of a Novel Viral Vector Gene Therapy Approach to Treat CACNA1A Cerebellar Disorders”! Thank you to everyone who contributed to this effort and @ODC_UPenn for your partnership
UPenn Million Dollar Bike Ride by ODC@MDBRide4Rare

Congrats to the 2023 #MDBR grant awardees! Thirty-eight projects were funded with $2.4M raised for 31 #rarediseases. Thank you to our MDBR community for their fundraising & commitment to the cause. See the complete list of projects here: orphandiseasecenter.squarespace.com/mdbr-2023-gran…

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samyounglab@SamYoungLab·
Finally, I want to thank Dr. Emre Kul, Uchechi Okorafor @MissSafie and the rest of the team for taking on this immense challenge to solve a fundamental problem in the gene therapy field.
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samyounglab@SamYoungLab·
Using a “humanized” hCD46 mouse model, we demonstrate these Ad vectors transduce cerebellar cell-types, including Purkinje cells, that are refractory to Ad5 transduction.
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samyounglab@SamYoungLab·
Therefore, to overcome the current limitations of Ad vectors to treat CNS disorders, we created chimeric 1st generation Ad vectors that utilize the hCD46 receptor.
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samyounglab@SamYoungLab·
However, these Ad5 vectors are unable to transduce many neuronal cell types that are dysfunctional in many CNS disorders. The human CD46 (hCD46) receptor is widely expressed throughout the human CNS and is the primary attachment receptor for many Ad serotypes.
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samyounglab@SamYoungLab·
Adenoviral vectors (Ad) have tremendous potential for CNS gene therapy approaches. Currently, the most common vectors utilize the Group C Ad5 serotype capsid proteins, which rely on the Coxsackievirus-Adenovirus receptor (CAR) to infect cells.
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samyounglab@SamYoungLab·
Viral vector gene therapy has immense promise for treating central nervous system (CNS) disorders. Although adeno-associated virus vectors (AAV) have had success, their small packaging capacity limit their utility to treat the root cause of many CNS disorders.
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