Lu-Yang Wang

My superstar PhD student Raphael Chan has his elegant work selected as the cover of the latest issue of The Journal of Neuroscience. This work shows a surprising twist that potassium leak is a pivotal element dictating heterogeneity of E-S coupling. jneurosci.org

I am so excited to announce that 2025 Pre-SFN “Giant Synapse Symposium” will take place at UCSD on Nov 14. Please join us for an exciting meeting with the latest breakthroughs in synaptic neurobiology. Registration is free but required for logistics. web.cvent.com/event/fac89654…

Very proud to share our latest work in collaboration with Amy Yang, Mike Salter, Sean Egan on Intersectin 1 as a pivotal molecule for controlling the emergence of calcium dependent replenishment of the readily releasable pool in developing central synapses.

Thank you all for congratulating notes which I appreciate profoundly!

Delighted to share our new Nature paper: rdcu.be/dNlMQ This works shows a surprising off-target effect of glutamate on another cell death channel, acid sensing ion channels (ASICs). It turns out that glutamate directly binds to ASICs as a positive allosteric modulator

A newly developed molecule could inform future therapies for stroke-related brain injury, finds #SKResearch in @Nature. Read ➡️ bit.ly/45Wh80h

This novel glutamate binding cavity can be exploited for development of stroke drugs, as exemplified by a new compound LK2 described in our paper.

@XiHuang18 @CAN_ACN @CIHR_INMHA @UofT Congrats to both mentor and mentee

@CAN_ACN @CIHR_INMHA @UofT Yeah! Congratulations Weifan for receiving the Brain Star Award🥳

Brain Star Award winner feature: Weifan Dong | University of Toronto - Identification of a potential new treatment for glioblastoma can-acn.org/brain-star-awa… Paper in Nature Cancer #Abs1" target="_blank" rel="nofollow noopener">nature.com/articles/s4301… @CIHR_INMHA @UofT

Check it out: most beautiful images of vATPase with a surprising partner on live synaptic vesicles from my brilliant colleague John Rubinstein and his team at SickKids Reaearch Institute & University of Toronto! science.org/doi/10.1126/sc…

@cacna1a @MDBRide4Rare @ODC_UPenn We are humbled to receive this award. We thank the MDBR and CACNA1A foundation for supporting our research.

Many congrats to Amy Yang for her new paper on the role of cerebellum in social recognition memory in Nature Communication published online: nature.com/articles/s4146…. So proud of my former trainees for their outstanding work and achievements.

Thrilled to be sharing the news of our latest grant award to @SamYoungLab @uiowa @IowaMed, signifying a crucial first step in the development of a future #GeneTherapy for #CACNA1A-related disorders. Check out his conversation with @PangkongFox here: youtube.com/watch?v=u3bBuW…

Pleased to share our paper in Neuron showing how Bilirubin acts as an agonist for TRPM2 and aggravates brain injury in stroke.| Home authors.elsevier.com/sd/article/S08…

@osmoland @CAN_ACN Awesome leadership over the most difficult period- thank you!

5:02 p.m. I guess my term as @CAN_ACN president is over ⛵️

awesome program

Was a pleasure to co-supervise Ke Lai (future post-doc of the Wang Lab) on this project. In our collaboration with Shanghai Jiao Tong University, we have uncovered ASIC channels as a target in treating Neonatal Jaundice. Check out our paper in @ScienceTM stm.sciencemag.org/content/12/530…

#ThrowbackThursday to 4 yrs ago, when I first began the important mandate I received from our PM @JustinTrudeau: to return science & research to their rightful place, after a decade of cuts & muzzling of scientists by the previous govt. Today, our decisions are based on evidence.

😍 #Want

RIP to my friend, mentor, and collaborator Professor Jim Howe of @YaleMed Pharmacology. Here we are sharing a laugh with Jim’s former student Stacy Irizarry. Neuroscience has just lost one of the great electrophysiologists of our generation but we will never forget Jim’s laugh!