Selbach Lab

MEK inhibition + growth factor → unexpected JNK activation 💥 Dual inhibition = significantly impaired tumor cell growth 🔬 SPIED-DIA = a powerful tool to dissect signaling & resistance #phosphoproteomics #cancerresearch #SPIED_DIA #MEKinhibition #DIA #precisionmedicine

We present SPIED-DIA – a spike-in enhanced phosphoproteomics method combining DIA with targeted sensitivity to uncover synergistic signaling in colorectal cancer cells. 👉 [rdcu.be/enPF2](rdcu.be/enPF2)

What happens to all those alternative transcripts? 👉 Many are translated 👉 Proteolytic processing adds even more diversity Integrated mRNA & protein isoform landscape now out on bioRxiv! doi.org/10.1101/2025.0… #proteomics #transcriptomics #systemsbiology

@michaelsteidel1 @DemichevLab Should be up by tomorrow the latest!

@SelbachLab @DemichevLab Great work. Can you give an estimate when data will be made available?

Excited to share our new paper in MCP! 🎉 DIA with Spike-In SILAC (DIA-SiS) boosts proteome coverage and quantification. Check it out: doi.org/10.1016/j.mcpr… #Proteomics #MassSpec #Research

Celebrating summer with our annual group barbecue

Read our latest preprint on targeted phosphoproteomics: "Spike-in enhanced phosphoproteomics uncovers synergistic signaling responses to MEK inhibition in colon cancer cells.": biorxiv.org/cgi/content/sh… #Phosphoproteomics #DIA #CancerResearch #Signaling #ColonCancer

Read the latest preprint on medRxiv: Cross-platform Clinical Proteomics using the Charite Open Standard for Plasma Proteomics (OSPP)

Combining data independent acquisition with spike-in SILAC (DIA-SiS) improves proteome coverage and quantification. Read our new preprint on bioRxiv. #SILAC #DIA #Proteomics biorxiv.org/content/10.110…

Read our latest work on how phosphorylation in Intrinsically Disordered Regions (IDRs) affects protein-protein interactions in Nature Communications. @TRrustemi nature.com/articles/s4146… #IDR #phosphorylation

Enjoy good lectures about DIA and the sun here in South Africa #UPSS2024

We would like to congratulate Fabian @CosciaLab for being awarded the European Research Council (ERC) Starting Grant 👏. #ERC mdc-berlin.de/news/press/erc…

Wishing our institute, MDC-BIMSB, a very happy 15th birthday 🥳 mdc-berlin.de/news/press/max… #MDC #BIMSB

Our latest preprint investigates the pathogenic mutations of human phosphorylation sites that affect protein-protein interactions. Using peptide-based interaction proteomics, more insights regarding the transcription factor GATAD1 were unveiled. @TRrustemi biorxiv.org/content/10.110…

Last week we went on a nice kayaking trip to Lübbenau/Spreewald 😃 #ProteomeDynamics #MS

We completed a 5x5 km team relay yesterday. Some of us already look forward to running again next year.

Interested in joining our Proteome Dynamics lab in Berlin? We are offering a postdoc position: tinyurl.com/y99xvxad

Looking for a method to identify drug targets? Our new paper on drug target identification by quantitative proteomics is now online: doi.org/10.1002/cmdc.2…

Proteomics Pride @MDC_Berlin in celebration of #CSDBerlin #proteomics #pride #mdcberlin

How can you predict kinase activity in phosphoproteomic data? This database allows you to do this, even for poorly annotated kinases. Read more in this new paper: doi.org/10.1021/acs.jp…”