Timo Mulder - eu/acc 🇪🇺🇳🇱
9.4K posts
@TimoMulder
(interim) Transformations | Product Management | Agile Coaching | Venture Building | Angel Investing
The first human age-reversal trial is officially happening. But before the FDA cleared it, Harvard professor David Sinclair had to pull off a mice experiment most scientists thought was impossible: "These mice had their optic nerve regenerated. We were able to show that using [the information theory of aging] method we could cure blindness in animal for the first time." Since then, he also discovered you could treat and reverse diseases like Alzheimer's, multiple sclerosis, ALS, kidney disease and liver disease in mice too: “It's not just the eye that can get reversed and cured of diseases. It's seemingly every part of the body.” It's what he calls "a universal reset of the body." He confirmed his method also worked in monkeys. Now humans are next. The FDA just cleared the first age-reversal trial. Life Biosciences raised $80 million to make it happen. As he put it: "The eye is just the beginning. We believe we can treat every tissue—a whole body reset."
Garry Tan @garrytan just ran the sharpest VC marketing play I've seen in years. And most people watching missed the architecture of it entirely. Here's what happened: Garry Tan — president of Y Combinator — built and open-sourced GStack: 15 Claude Code skills for founders building with AI agents. The repo hit 37,000 stars and 4,600 forks. Then, buried at the end of the final output — after the tool had already designed your architecture, killed your over-engineered vector pipeline, reviewed your schema, and told you what to build next — came this: "What you just experienced is about 10% of the value you'd get working with a YC partner." "The other 90% is the network of founders who've done it before you, the batch pressure that makes you ship faster than you thought possible, weekly dinners where people who built billion-dollar companies tell you exactly what to do next." "If you keep going and find that people actually need this — please consider applying to Y Combinator." Then a link. Why this is a masterclass — not just in marketing, but in trust architecture: Most VC content follows the same sequence: Brand → claim → ask. "We're the best. Here's why. Apply to us." Garry reversed it entirely: Tool → proof → ask. "Here's something genuinely useful. Use it. Experience the value. Now imagine 10x of this, with humans." The ask doesn't come until after you've already felt the gap. That's not a pitch. That's a demonstration that creates its own desire. The specific line that makes it work: "The engineering barrier is gone. What remains is taste — and you just demonstrated that." That one sentence does three things simultaneously: Validates the founder reading it — you have taste Reframes what YC is selling — not funding, not resources, taste refinement at scale Makes the application feel like a natural next step rather than a cold ask Most accelerator pitches sell access to capital and networks. Garry is selling something more seductive: confirmation that you're the kind of person who belongs in the room. In a world where anyone can build with Claude Code over a weekend, the differentiation isn't technical capability. It's judgment. Taste. Knowing when to kill the vector pipeline. YC has always understood this. GStack just made the argument viscerally, experientially, in 15 skills worth of free value — before asking for anything in return. #YCombinator #GarryTan #GStack #ClaudeCode #StartupMarketing #TrustArchitecture #Founders #VentureCapital #AITools #ContentStrategy
David Sinclair said: "You can reverse aging by 75% in 6 weeks… by reinstalling the "software" of the body so that it's young again." This idea sprouted when he proved in his first experiment that you can accelerate aging in mice: "We took two mice born on the same day—same age, same genetics. We 'scratched the CD' of one mouse, corrupting its software and accelerating its aging. The result was dramatic. One looked far older than its brother." He believed if you can give aging, you can also take it away. Tomorrow, I'll share his experiment on how he reversed aging in mice (and then Monkeys). — @davidasinclair
Dear President @realDonaldTrump this is what the new Dutch Prime Minister @MinPres Jetten wrote about you after you won the elections in November 2024: “Trump, a convicted criminal, becomes president of the US. A misogynist who wants to take away hard-won freedoms, such as abortion. A man who openly flirts with dictators. What lies ahead are years of chaos, division, and recklessness.” Please don’t trust him, the man is a leftish liberal politician and an enemy of the people and he hates your guts. He is now also attacking @PM_ViktorOrban who is a thousand times better leader then Jetten himself.
French judge Nicolas Gouyou, who issued an arrest warrant for Netanyahu at the ICC: • Visa and Mastercard have blocked all my cards • I cannot make any purchases • I am a judge, yet treated like a criminal • Judges, lawyers, and politicians are being intimidated • A colleague told me my name won’t be removed from the blacklist until Trump’s term ends • Despite intervention by the French president, U.S. authorities have not responded
BREAKING: Just five minutes before Trump's announcement to halt the attacks on Iran, massive trades reportedly hit the market. In one move, $1.5 billion in S&P 500 (ES) futures was bought while $192 million in oil (CL) futures was sold. These orders were 4–6x larger than anything else at the time. The trader seemingly made huge gains. Unusual.
