Neil Adia

Our visual understanding of mitochondria has gone from this… to this

“I’ll fix my references at the end” Me at the end:

@shah_ps I wish I saw this earlier!!!!!

Sorry I’m not sorry

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses. (👇 I recommend sound ON for the video 🎹) 1/

Excited that SpatialData is out @naturemethods! With @OliverStegle & @notjustmoore labs, we introduce & implement a dataframework & fileformat for multimodal spatial omics, based on the @openmicroscopy standard. Read at nature.com/articles/s4159… & try here spatialdata.scverse.org.

**Is single-cell data integration a solved problem? ** Lots of great methods, but still not quite yet! Specifically, Check Dataset Imbalance! 🎉 Excited to announce that our study on dataset imbalances in single-cell analysis just hit Nature Biotechnology (@NatureBiotech)! 🎉 Dive into our paper titled "Characterizing the impacts of dataset imbalance on single-cell data integration" here: nature.com/articles/s4158… 🔬 We've thoroughly assessed how dataset imbalances can twist the results of single-cell integration and batch-correction, affecting everything from cell-type classification to differential expression. Our work doesn't just highlight the issue; it offers solid solutions! 🧩 Starting with balanced PBMC data, we uncovered how changing cell-type balance disrupts integration results. But, when we cluster similar cell-types hierarchically, the magic happens – stability is dramatically improved! 📊 We didn't stop there. Our research extends to how these imbalances influence crucial downstream analyses. The impact? Statistically significant changes that could sway biological conclusions. 🛠️ To empower researchers, we've developed a suite of guidelines and introduced innovative balanced clustering metrics. Our tools are designed to navigate the tricky waters of dataset imbalance, ensuring accurate, meaningful results. Check out our full tutorial: github.com/hsmaan/Iniquit… 🧬 And, for a cherry on top, we've redefined benchmarking standards with new metrics that ensure fair and nuanced interpretation of integration results. Future benchmarking, we've got you covered! Explore our balanced clustering package: github.com/hsmaan/balance… 🔧 Our comprehensive toolkit, including code, data, and detailed documentation, is now fully open-source! We're setting new standards for method development and benchmarking in single-cell integration, with an eye on the broader horizon of representation learning. Get all the goodies here: github.com/hsmaan/Iniquit… Huge congratulations to all the authors, especially the first author, Hassaan Maan, a PhD student I co-supervise with @kieranrcampbell, who almost single-handedly led this project! @UHN @MBPatUofT @VectorInst @UofTCompSci @UofT_LMP @pmcc_ai @UHNAIHUB

Thanks to @UCDavisCOE for highlighting student-driven research in @PShahLab by @NitinSaiB1, Eshan Thilakaratne, and @UCD_NeilA! Our innovation comes from our top notch trainees.

Thanks for asking to use my microscopy image for your flyer and for crediting me 🙄🙄🙄 Seriously? Classic.

LET’S GOOOOOOO @ucdavis #GoAgs

Gained some fresh perspectives from this year’s Qatar Process Safety Symposium on “Vigilance”, especially on expanding safety analysis from “what didn’t go wrong” to also include “what went right”.

An interesting alternative to receiving drugs by skin injections #DEB263 nature.com/articles/d4158…

One of the biggest edges that we gain from immense computing power is the ability to make predictions based on an amount of variables many times more than what the human brain can work with. Here, we see it in action through disease prediction. #DEB263 nature.com/articles/s4158…

Donating blood is easy, safe, and needed, now, more than ever. Replenish lifesaving blood supplies today by scheduling an appointment at a blood donation center near you and encourage others to do the same. #NationalBloodDonorMonth ucdavis.health/Donate-blood

Pls retweet: I’m hiring! 😃🎉 Principal Sci Researcher in my 3D culture lab @Genentech. 1 yr term. Perfect for new PhDs/PDs that want to gain industry experience. Int’l candidates welcome. Benefits: -$120-150k salary -health ins -mentorship (from me!) Start date: Feb-Apr ‘22

Humanity did not come up with answers such as genetic therapy only to keep them from the people they were intended for. Part of overcoming global health challenges involves making these treatments attainable to society. #DEB263 #biotech #Biotechnology nature.com/articles/s4158…

Making baby steps in the vastly fascinating world of neuroscience. I learned a lot about the analysis of single neuron activity in response to stimuli. Excited to see what’s next!