Utrecht Virology Lab

Getting low-confidence #AlphaFold predictions for your favorite membrane protein? Try adding some fatty acids to the mix! 👇

For a plain-language overview of our work, see this lay summary courtesy of Kudos: growkudos.com/publications/1…

Voor de alllerlaatste keer vanuit de examenzaal. Mijn bloedjes van cursisten zijn aan het zweten op het monsterlijke tentamen dat ik voor hen heb samengesteld. Hopelijk heb ik de vlam kunnen doorgeven en zitten er een paar toekomstige virologen tussen

Out now at @PLOSPathogens. Nice collaboration with @DanielHurdiss @UtrechtVirology. Some beautiful glycoproteomics work by @TShamorkina to map the N- and O-glycan shield of these coronaviruses infecting whales and dolphins 🐋🐬🐳. journals.plos.org/plospathogens/…

Our paper describing the #cryoEM structures of unusual spike proteins from marine mammal–infecting gammacoronaviruses is now published in PLOS Pathogens! 🐬 journals.plos.org/plospathogens/…

Structure of SARS-CoV-2 spike in complex with its co-receptor the neuronal cell adhesion protein contactin 1 biorxiv.org/content/10.648… Check out our new preprint. Cool structure by Sabrina Krepel with Bert Janssen. Thanks to co-authors @DanielHurdiss @UtrechtVirology #covid #pais

The newly established NeCEN Utrecht is looking for a #cryoEM scientist! uu.nl/en/organisatio… Work with a new Krios 5 + pFIB and support cutting-edge life science research. 📍 Utrecht | 🗓 Apply by 30 April Please share with your network!

Excited to welcome @tejashyam_k to the ERC starting grant team, as he starts his PhD today! Teja joins us from the @saikatLab, where he built a solid foundation in biochemistry & #cryoEM 🔬 Looking forward to exciting science ahead!

Another one flew off today. We all said Good bye to @tejashyam_k with both joy and heavy heart as he heads to @DanielHurdiss lab at @UniUtrecht to start his PhD. We wish him all the best and looking forward to his success and an exciting journey ahead.

The gH/gL/gO Complex of Elephant Endotheliotropic Herpesvirus 1A Functions as a Receptor Binding Complex biorxiv.org/content/10.648… #biorxiv_micrbio

How can AI and #cryoEM help save some of the biggest babies on the planet? 🐘🔬 Our new preprint identifies EEHV gH/gL/gO as a receptor-binding complex and a promising vaccine candidate, now being tested in young elephants across European zoos! 💉 tinyurl.com/4r3fpk4m

Thrilled, and admittedly relieved, to see this major investment in Dutch #cryoEM become reality! 🇳🇱🔬 Honoured to be a co-applicant on this national initiative and very excited for the opportunity to advance our work in cellular structural virology! uu.nl/en/news/33-mil…

Rounding off an incredibly busy week with the excellent third installment of the Dutch Structural Biology Meeting! Many thanks to Arjen for the kind invitation to present our lab’s work.

Back from the 9th International Calicivirus Conference in Banff! We really enjoyed both the stunning mountain views and the exciting science being shared in the field. Thanks to the organisers for putting together this great meeting. Lots of exciting collaborations ahead!

Did you know amphibians and fish have viruses that are very similar to human influenza B viruses? We didn't know either, but Eddie Holmes found them and we had a closer look at their HAs and NAs. with @gabagagan @WardLab1 @RobertPdeVries1 @dishabhavsar science.org/doi/10.1126/sc…

CryoCloud Map of the Month: PDCoV RBD in complex with two neutralising Fabs For August, we reprocessed the receptor-binding domain (RBD) of the porcine deltacoronavirus (PDCoV) spike in complex with two neutralising antibody Fabs fragments. 🔬 Cryo-EM reveals two distinct neutralising epitopes, pointing to pathways for synergistic antibody combinations against a potential pandemic threat. This study also showcases how multiplexing antibodies delivers more structural insight with less cost and processing time. 🧠 Processing on CryoCloud: • 4,736 movies • 35.5 h of cloud compute • Final map: 2.7 Å from 120,787 particles - representing an improvement of 0.3 Å vs the previously published 3 Å map Publication from the @UtrechtVirology Lab: nature.com/articles/s4146… Send us a DM for more info or visit cryocloud.io! #CryoEM #StructuralBiology #AntibodyDiscovery #Virology #EpitopeMapping #SBDD #MapOfTheMonth #MOTM #CryoCloud

Excited to share our new @NatureMicrobiol paper revealing the most complete arenavirus glycoprotein complex (GPC) structures to date 🤩@TheColinMann @HarvardMicro @VirologyHarvard nature.com/articles/s4156…

Genome-wide CRISPR screen reveals key role of sialic acids in PEDV and porcine coronavirus infections | mBio journals.asm.org/doi/10.1128/mb…

Apparent outbreak of acute flaccid paralysis, cause unknown in Gaza. Very limited testing ongoing/ possible. Could be a range of possibilities nos.nl/artikel/2577699

New review paper from the influenza group @UtrechtVirology together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on cells in NPJ viruses @NaturePortfolio doi.org/10.1038/s44298…

Excited to share our paper identifying that bat coronavirus HKU5 uses ACE2 from its native bat host and American mink as a receptor. This highlights farmed mink has a high risk intermediate host for HKU5-like viruses. nature.com/articles/s4146… @YaleIBIO @YaleMed