The Yttri Lab

1/5 NEW in NEURON! We asked what forelimb M1 contributes to striatal and behavioral dynamics. Short answer: almost everything*. @Markolas11 trained mice to perform a joystick reaching task, w/ and w/out a go cue, then lesioned CFA tinyurl.com/M1Lesions @cmuneurosci @CmuScience

A fun article about our work and the Olympics. There's some interesting relationships between skiing and basal ganglia function @CmuScience @ahmari_lab @BarbShinn theconversation.com/hesitation-is-…

and super cool neurocampus building!

super excited to be giving a talk today at University of Bordeaux. thank you Nicolas Mallet for the invitation!!!

I am so curious and fascinated to find out what the heck this is

Here's the tweetprint on pain, blocking its affective content, and its effect on behavioral and neural dynamics!

ok. 2 cool science summaries: 1)we discovered clear, discrete pain states - not just behaviors 2)no-pain and treated-pain were not the same, in part due to intervention targeting just the affective side, not numbing everything. Also kinda makes sense in my personal experience?

I'll let Greg do the tweetprint, but he led a Phenomenal interdisciplinary team effort. Great science in every way. It's open too! Also part of the paper, you can build your own behavior rig with full analysis software for a tenth the price of commercial. Inquire if interested

Hot off the @Nature press! A-SOiD behavior library developed specifically for pain studies quantifies a new chemogenetic gene therapy that targets opioid circuit in ACC without addictive properties @FlyBottleEscape @CmuScience @cmuneurosci nature.com/articles/s4158…

So proud of @MattGeramita and his stellar work on striatal dynamics, decisions, and impulsivity. Pertinent for thinking about prob vs deterministic frameworks too. Also, suggests indirect may be doing more(cognitive?) than just opposing direct pathway nature.com/articles/s4159…

Come see Paul present his very cool data + analysis today at 1pm @SfNtweets

SPNs are briefly active + only for specific events. When driven randomly or for long dur, interpretation is hard. SPN attenuate response to light after a few secs (and Bstem response?) These results indicate STR's role in policy-based RL + are at odds with basic action selection

When applied contra, ipsi, or bilaterally to left turns, the effect was the same: D1/D2 stim biased mice to turn left more often, regardless of the side of stim. Note, bias is incomplete and did not induce an action, consistent with learning but not action selection

Huh, it's been 8 months since I was on here. Better late than never. I hope this new-ish paper will challenge people to think about the interpretations of our models STRIATUM SUPPORTS REINFORCEMENT AND NOT ACTION SELECTION (!!!) cell.com/cell-reports/f… @CmuScience @cmuneurosci

excited to be giving a talk @ UPenn today, with invite from @Fuccillomarc and @FlyBottleEscape A preview of my first slide....

I'm still chewing through this one, but I think it's a keeper cell.com/trends/neurosc…

I'm revamping a masters-level Systems Neuro course this spring. Please HMU with your favorite reviews and perspective pieces! Extra points for approachable and/or thought-provoking. Any topic is welcome! I might end up biasing to the BME-heavy audience

Super exciting work and possibilities discussed today in the Brain Behavior Quantification and Sync consortium kickoff today!!! Great job to all (and got nerves for a talk for the first time in a while!)