⚡️GREG_CORDER⚡️

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⚡️GREG_CORDER⚡️

⚡️GREG_CORDER⚡️

@FlyBottleEscape

Associate Professor @Penn • Dept Psychiatry + Dept Neuroscience + Dept Anesthesiology | Pain • Placebo • Poppies • Psychedelics

Philadelphia, PA Katılım Mart 2016
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⚡️GREG_CORDER⚡️
⚡️GREG_CORDER⚡️@FlyBottleEscape·
🧠⚡️💊New @Nature publication ! Mimicking opioid analgesia in cortical pain circuits We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy nature.com/articles/s4158… @PennMedicine
nature@Nature

Researchers identify the neurons involved in the emotional distress associated with pain go.nature.com/3NkL1SB

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Anthony Berndt
Anthony Berndt@anthony_berndt·
@FlyBottleEscape Tradition was, in my past labs, that you circle the ceiling tile you dent with the cork with a signature and date.
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Jason Shepherd
Jason Shepherd@JasonSynaptic·
Very excited for our new paper, now out in @CellCellPress! /🧵The protein Tau forms intracellular toxic tangles in neurons in Alzheimer’s disease and Tauopathies. Tau pathology slowly spreads from cell-to-cell but the mechanisms of Tau transmission are not clear. /1
Jason Shepherd tweet media
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⚡️GREG_CORDER⚡️
⚡️GREG_CORDER⚡️@FlyBottleEscape·
I did some kind of PI record today: 95 intrathecal injections and 61 emails sent and 5.7 miles walked in between .. and I’m still not caught up on my shit
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⚡️GREG_CORDER⚡️
⚡️GREG_CORDER⚡️@FlyBottleEscape·
saw @A24 Backrooms in this procedurally generated, liminal theater in Pittsburgh .. unsafe vibes
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⚡️GREG_CORDER⚡️@FlyBottleEscape·
Yes there is a hard cap on total dollars: grants.nih.gov/grants/guide/n… NIH Reporter may show a PI on 4-5 grants as MPI but the public doesn’t have access to the budget split. For example, I’m MPI with FOUR other labs, so my direct dollars are $105k/year (vs modular single PI R01 is $250)…. This is a super cool project and has generated over 20 papers and multiple patents… this type of collaborative science will be killed by a shortsighted cap
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Ramakanth Kavuluru
Ramakanth Kavuluru@BioNLProc·
There is no limitation on total dollars received and also being Co-I on others grants.
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Ramakanth Kavuluru
Ramakanth Kavuluru@BioNLProc·
All those who seem to oppose this seem to be big lab PIs who prefer to have 4 or 5 grants running simultaneously in their labs :-) They r all sure they are right with no scope for nuance. They think they r getting "destroyed" & comparing this to DOGE. What a way to think/live🤦‍♂️
Ramakanth Kavuluru@BioNLProc

This is an important initiative that could help many PIs struggling to get funded. NIH is seeking feedback on whether limiting to a max of 2, 3 or 4 simultaneous funded projects for a PI is reasonable. It asks for pros, cons, and other loopholes people can exploit.

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⚡️GREG_CORDER⚡️@FlyBottleEscape·
@MelindaBChu1 @Aiims1742 @NIH No one is being greedy. Your arguments are not grounded in facts… there is a cap, you don’t seem to want to acknowledge that. Calling by number of awards doesn’t account for collaborations (split directs) or size of award
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Melinda B. Chu
Melinda B. Chu@MelindaBChu1·
@FlyBottleEscape @Aiims1742 @NIH You can assign PIs to a project or switch. Stop being greedy and help early career faculty/ Post-Docs with their careers. Admin / Dept. can make new positions or promote people. They do it all the time.
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Anirban Maitra
Anirban Maitra@Aiims1742·
Important Request for Information (RFI) from @NIH “Proposal to Cap the Number of Simultaneous Research Project Grants per Principal Investigator to Support More Researchers and Maximize Scientific Productivity and Innovation” grants.nih.gov/grants/guide/n… Some suggested caps & impact:
Anirban Maitra tweet media
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Melinda B. Chu
Melinda B. Chu@MelindaBChu1·
This helps early career PIs running new labs and smaller univeristies. A lot of big PIs get grants renewed just because and they have variations on same project for multiple grad students / Post-Docs and also a.lot of big PIs are at universities with huge endowments, other sources of funding, and with thousands of administrators. I’d cut the Administrators myself to make room for more research.
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Jason Shepherd
Jason Shepherd@JasonSynaptic·
@FlyBottleEscape @DrJKhokhar Yes...so comment on it! We need more folks to engage with them (even if we know it might not end up being in good faith anyway).
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Jason Shepherd
Jason Shepherd@JasonSynaptic·
There's a lot going on at the NIH right now. IMO capping PI total funding is a good thing when resources are thin. This is not a new discussion (as opposed to the OMB unrelated BS). I suggest all stakeholders comment on this proposal in a thoughtful way. grants.nih.gov/grants/guide/n…
Anshul Kundaje@anshulkundaje

Utterly ridiculous proposal to expect academic labs to be competitive especially with industry with TWO measly grants. Yup definitely going to respond to this one to try to bury it.

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Prachee Avasthi
Prachee Avasthi@PracheeAC·
There will be lots of narratives about this proposal to cap grants per NIH investigator given the fraught political climate but I’m glad the NIH is continuing to grapple with how best to responsibly distribute the public dollars still in its charge As with all requests for information on important policy proposals, I suspect there will be shockingly few respondents. And the responses that are sent will likely be dominated by backlash from those quite practiced and efficient at lobbying for their individual interests, even if they represent a vocal and powerful minority relative to a broader ecosystem that this would impact. If this affects you (though I’d argue distribution of resources by the largest public funder of health research in the world affects all of us), I’d do my homework and weigh in. grants.nih.gov/grants/guide/n…
Prachee Avasthi@PracheeAC

It is not insane IMO and can be about a lot of other things. You’ll remember that a decade ago the NIH proposed something similar, the grant support index, that was meant to also achieve the same: broader distribution of research dollars and higher funding rates instead of a Matthew effect of more grants to fewer investigators with diminishing returns. Many young PIs were in support. Back then, I submitted a letter in support of it on behalf of many signatories newpislack.wordpress.com/open-letter-on… The NIH-wide initiative had its roots in related capping policies that resulted in significantly increased funding rates at NIGMS relative to other ICs. The few and powerful at rich institutions (massive outliers in the grant recipient distribution) killed the initiative before it could even be thoroughly discussed. Back when the GSI was proposed, ~6% of NIH funded researchers had the support equivalent to 3 R01s. If going by RPGs not total dollars, I’d expect that to be an even smaller percentage of affected researchers now given the proliferation of R35 as a mechanism that consolidates multiple projects into a single award. IMO, the over-proliferation of completely unsustainable soft money positions is not a slam dunk justification to act as a sink for public research dollars distributed by an agency beholden to more than those researchers and institutions. This is not really my fight anymore, other than a vested interest in thriving federal funding for scientific research, responsibly deployed to support new ideas and institutions not just concentrate them … but I do think seeing this as entirely about a hostile administration threatens to dismiss a serious policy proposal that should be thoroughly considered on its merits

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