Eterna

This week, learn about the crowdsource RNA design platform, Eterna, and Anthony Stohr's switch work. In the future, how could Eterna be used to tackle to 3D RNA structure problem? Meeting ID: 934 4593 5624 Passcode: 802843 Mailing list: groups.google.com/g/casp-rna-sig

A new 3-state Replicase challenge has been launched on Eterna and will only be open for two weeks before sequences are collected for experimental testing at @RDasLab. Will Eterna players be able to improve the catalytic activity of the RNA polymerase? eternagame.org/labs/14183416

We got single RNAs to compute functions like all logic gates, A>B, and A*B/C^2, relevant for tuberculosis detection! Now looking for partners to scale to complex applications. Awesome collaboration with @WJGreenleaf @purveshkhatri @eternagame at doi.org/10.1038/s41557…

In addition to the RibonanzaNet server hosted by @RDasLab, RNA structure fans can try the new pseudoknotted prediction model in Eterna's RNet Study collection. The 108 puzzles are a mix of experimentally-validated structures and synthetic fabrications. eternagame.org/collections/13…

Celebrate World RNA Day on August 1 with Eterna In the latest Education Corner, learn about Eterna, an online game which models the base pairing and secondary structure of RNA sequences cdn.rcsb.org/rcsb-pdb/gener…

Coming up this weekend, Eternacon will feature online presentations about fellow #citsci platform @the_zooniverse and how participants of both Zooniverse and Eterna have created machine learning tools for projects. @NOIRLabAstro Register for free at eternagame.org/eternacon/2025

We're excited to move forward with this next step in Eterna's governance. Same core staff and a renewed focus on sustaining and growing Eterna. Hear directly from Eterna lead developer and Frameshifter director @luxaritas at Eternacon this weekend: eternagame.org/eternacon/2025

Frameshifter is a fiscally sponsored project of the 501c3 @sprblm_. Learn more about Frameshifter at frameshifter.org Our team has discussed this step for some time, and initially shared our plan to start a new organization with our community a few months ago.

Eterna's team is excited to announce the launch of Frameshifter, a new nonprofit program established to steward Eterna's future and advance public engagement in scientific research through games, collective and hybrid intelligence, and human centered design.

So excited to see our work finally published in RNA @SanfordRNAlab, @RDasLab, @eternagame, Michael D. Stone! Super cool work with exciting implications behind RNA drug design!!!

Registration for Eterna's annual online conference July 26-27 is open! Come hear from both researchers and players about new approaches to structure-based RNA design and understanding RNA structure. #citsci Full program and free registration at eternagame.org/eternacon/2025

Thank you RCSB PDB for inviting Jill to write about the many ways Eterna puzzles are used to introduce #RNA structure in the #biology and #biochemistry classroom at different levels of education. #SciComm #STEM

🧬 TODAY: Solve puzzles. Help invent new medicines. Eterna, created by Stanford Medicine, turns cutting-edge biomedical research into puzzles you can solve. 
Design RNA molecules that could one day treat diseases, predict how RNA folds, and advance drug discovery. Your designs are tested in real university labs, and your contributions help scientists build better RNA models. It’s free, global, and open to anyone: scistarter.org/eterna @eternagame @StanfordMed

Eterna players support the RNA research being performed by academic labs at US universities and strongly believe federal funding of these research programs should be fully restored to maintain America's leadership in both science and biomedical entrepreneurship.

National DNA Day celebrates the completion of the human genome project in 2003 and the discovery of the double helix in 1953. The continuing work of dedicated scientists to unlock the function of genes and RNA in the human body is leading to important advances in medicine.

#RNA structure prediction remains unsolved -- nice tech feature incl #deeplearning and #CASP16 in @Nature nature.com/articles/d4158…

Videos of the presentations are available on the Eterna website at eternagame.org/eternacon/2024. Eternacon 2025 will be July 26-27. 🧬Come get involved with #citizenscience!🧬

Eternacon 2024 featured great talks on how Eterna players helped RNA structure researchers improve the preparation of RNA sequences for chemical mapping, particularly the formatting of padding and barcodes to reduce misfolds and smooth read counts.

@phil_bevilacqua @NAR_Open Ugh, non-native flanking sequences causing alternative conformations. Tell me about it. Congratulations on developing CHITA!

Pleased to share our new article "Direct testing of natural twister ribozymes from over a thousand organisms reveals a broad tolerance for structural imperfections" out in @NAR_Open academic.oup.com/nar/advance-ar…

Who doesn't love a humans vs. machines challenge? OpenKnot round 7 will test how well Eterna players can design RNA sequences to fold into a specific pseudoknotted structure against 3D RNA design algorithms created by research groups. Learn more at eternagame.org/labs/13612324