Our preprint describing the adaptation of the PIP-seq platform for scalable, inexpensive multiomics is now live on BioRxiv! Congrats to Zhifei Luo (@LuoZhifei)! biorxiv.org/content/10.648…
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William J. Greenleaf
159 posts
William J. Greenleaf
@WJGreenleaf
Professor, Stanford University, Department of Genetics. Exploring the physical genome
Stanford U, Stanford CA Katılım Temmuz 2011
121 Takip Edilen11.2K Takipçiler
William J. Greenleaf retweetledi
Does every enhancer work with every promoter?
With @jengreitz and @WJGreenleaf, we revisit this long-debated question and resolve an outstanding contradiction in the field.
A tour 🧵👇
biorxiv.org/content/10.648…
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We are excited to welcome Haiyin Chen as RAMP’s new Scientific Director! With 10+ years of pharma & biotech experience in immunotherapy and infectious disease, Haiyin will lead research and partnerships to accelerate RNA science and translation. @StanfordRNAMed
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Our Human Multiomic Development Atlas paper is out in Nature today! A heart-felt "thank you" to all co-authors for their tireless work on this complex yet exciting project! Congrats all! nature.com/articles/s4158…
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The RNA Medicine Program at Stanford is also looking to hire postdoctoral fellows -- so if you are interested in solving scientific problems related to RNA stability, efficacy, delivery, or combinatorial dosage, please reach out to me via email.
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My lab is looking to recruit postdoctoral scholars over multiple projects including combinatorial expression perturbations for cell state engineering, and modeling and perturbing human tissue development with tractable human organoid systems (primarily heart and brain)
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Congrats to @juliaschaepe and @marklundem on the recent publication of their work linking the binding behaviors of TFs in vitro and in vivo! Out in Cell now: cell.com/cell/fulltext/…
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Very happy to share the most recent work from the lab!
Tong Wang@twang0518
1/ 🧵Happy to share our preprint from @WJGreenleaf’s Lab: beCasKAS, our method to directly detect #CRISPR base editor off-targets in primary cells. We additionally show how non-coding edits can be triaged for epigenetic dysregulation using deep learning. biorxiv.org/content/10.110…
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Our preprint describing single-cell multiomic dissection of human lung development is now out on bioRxiv! Congratulations to @bySamHKim and all co-authors! doi.org/10.1101/2025.0…
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Pleased to announce this latest work from the lab!
Betty Liu@bettieliu
Delighted to share our latest work deciphering the landscape of chromatin accessibility and modeling the DNA sequence syntax rules underlying gene regulation during human development! biorxiv.org/content/10.110…. Read on for more 🧵 [1/16]
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William J. Greenleaf retweetledi
1/ Have you ever run out of memory while trying to analyze a large scRNA-seq or scATAC-seq dataset? Check out our new preprint from @WJGreenleaf lab about BPCells: an R package for high performance single cell analysis. Read on for more 🧵
biorxiv.org/content/10.110…
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William J. Greenleaf retweetledi
Our work using thermodynamic principles to link in vitro TF affinities and kinetics to single-molecule chromatin states in cells is now on bioRxiv! Amazing effort by first author @juliaschaepe in @WJGreenleaf lab:
biorxiv.org/content/10.110…
@Stanford @scilifelab @Stockholm_Uni [1/9]
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Huge congrats to Howard! We will sorely miss him here at Stanford, but wish him all the best for this immensely exciting opportunity!
Jay Bradner, M.D.@jaybradner
Excited to welcome @HowardYChang to @Amgen as our new SVP for Research & CSO! A pioneering physician-scientist, Howard’s expertise in genetics, oncology, & inflammation will help us push the boundaries of discovery. We’re excited to embark on this journey together to redefine the future of science and medicine! amgen.com/newsroom/press…
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Incredibly excited that our paper linking single molecule states of TF binding to gene expression using quantitative thermodynamic models is out in Nature today. An amazing collaboration with the Bintu Lab. Congrats to Ben, Michaela, and Julia! nature.com/articles/s4158…
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Our single-cell, pan-cancer analysis of open chromatin in human cancers, done in collaboration with TCGA and the Chang and Corces labs (among others including Illumina), is out in Science today. Congrats to Laksshman Sundaram and all authors! science.org/doi/10.1126/sc…
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The Greenleaf and Gifford Labs are looking for graduate students and postdocs interested in perturbing transcription factors and chromatin remodelers in human heart organoid systems with an aim of quantitatively understanding drivers of normal human development. Email Will!
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The Greenleaf lab is looking to recruit graduate students and postdocs interested in combinatorial cell state engineering. If you are interested combining multiplex perturbations and single cell readouts to "push" cells into target states, email Will!
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The Greenleaf and Pasca Labs are looking for graduate students and postdocs interested in perturbing transcription factors and chromatin remodelers in human brain organoid systems with an aim of quantitatively understanding drivers of normal human development. Email Will!
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William J. Greenleaf retweetledi
Our human multipotent lymphoid progenitor paper is finally out! nature.com/articles/s4146… After revision, we added more in vitro validations of the lympho-myeloid potential of this HSPC population. Lots of thanks to @Bendall_Lab & @WJGreenleaf
YeEun Kim@YeEun_Kim__
Excited to share my preprint with @Bendall_Lab and @WJGreenleaf on novel human lymphoid progenitors! Turns out they had been misidentified as myeloid progenitors thus far. Check out how we revealed their true identity in the tweetorial below 🧵biorxiv.org/content/10.110…
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William J. Greenleaf retweetledi
The Greenleaf and Pasca Labs are looking for graduate students and postdocs interested in perturbing transcription factors and chromatin remodelers in human brain organoid systems with an aim of quantitatively understanding drivers of normal human development. Email Will!
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