Das Lab

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Das Lab

Das Lab

@RDasLab

Our lab seeks an agile and predictive understanding of how RNAs structurally code for information processing and replication in living systems.

Stanford, CA Katılım Nisan 2019
111 Takip Edilen2.6K Takipçiler
Das Lab
Das Lab@RDasLab·
Third (& last?) intense week of #RNA server-only targets on #CASP17: small molecule binding ribozymes and aptamers & more group II introns in multiple states. Strange mix of natural and non-natural RNA and compounds and proteins. Looking forward to less crazy pace in next weeks.
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Das Lab
Das Lab@RDasLab·
The 2nd week of #CASP17 is closing, with more group II introns and some other RNAmake synthetic designs — monomer and dimer (!) targets for both. And more #RNA targets are coming in week 3: #557" target="_blank" rel="nofollow noopener">predictioncenter.org/news.cgi#557
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Das Lab
Das Lab@RDasLab·
First natural #RNA in #CASP17 is a group II self-splicing intron, and it’s also the season's 1st multistate target! Will server algorithms detect homologous group II intron structures to help modeling? Can servers model both unspliced and spliced states? predictioncenter.org/casp17/targetl…
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Das Lab
Das Lab@RDasLab·
Two more #CASP17 #RNA targets: OpenKnot @eternagame molecule from AI designer gRNAde @chaitjo & triphosphorylating ribozyme selected by Muller lab @UCSanDiego. All 8 RNA targets are non-natural — how will modeling methods do without MSAs, templates, homologous training examples?
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Das Lab
Das Lab@RDasLab·
First two targets in #CASP17 are #RNA, and they're designs from the online videogame @eternagame. Hope the bots preparing for CASP have been playing Eterna!
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Protenix
Protenix@ai4s_protenix·
🚀 Introducing Protenix-v1, the first open-source model achieving AF3-level performance Highlights: 🔹 Verified inference-time scaling behavior 🔹 RNA MSA & protein template support 🔹 Additional release: Protenix-v1-20250630 trained on a larger dataset 🔹 PXMeter v1.0.0 for transparent evaluation (6k+ complexes, time-split & domain-specific subsets) 🔗 Code: github.com/bytedance/Prot… 🔗 Eval toolkit: github.com/bytedance/PXMe… 🔗 Online server: protenix-server.com
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Das Lab
Das Lab@RDasLab·
It's official: @NVIDIAHealth has returned to co-organize Part 2 of the @StanfordMed Kaggle 3D RNA folding competition. Kagglers incl Part 1 leader @raojohng have already advanced @nvidia RNApro into the best publicly available notebook on the leaderboard: kaggle.com/competitions/s…
NVIDIA Healthcare@NVIDIAHealth

🧩 We’re thrilled to collaborate with @StanfordMed and @HHMIJanelia on the Stanford RNA 3D Folding Part 2 Challenge. Help advance the science of RNA structure prediction and push the boundaries of AI for biology. Kickstart your solution with RNAPro, our new baseline model built on key insights from the first competition. 🤔 Can you solve it nvda.ws/4q0FRsw

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Das Lab
Das Lab@RDasLab·
In 2 weeks, 9 @kaggle teams have beat AlphaFold 3 score (0.372) in predicting hidden 3D structures of #RNA, including complexes with small molecules & proteins. What will it take to beat the best template oracle (0.554)? kaggle.com/c/stanford-rna…
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Das Lab
Das Lab@RDasLab·
Inspired by 2025 Stanford #RNA 3D folding @kaggle challenge outcome, we’ve collected cryo-EM of new-to-Nature RNA folds, RNA complexes with small molecules and proteins, and assemblies up to 6000 nts - and launched PART 2! Deadline: March 19, 2026. kaggle.com/c/stanford-rna…
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Das Lab retweetledi
Eterna
Eterna@eternagame·
A new 3-state Replicase challenge has been launched on Eterna and will only be open for two weeks before sequences are collected for experimental testing at @RDasLab. Will Eterna players be able to improve the catalytic activity of the RNA polymerase? eternagame.org/labs/14183416
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Das Lab
Das Lab@RDasLab·
Wonderful collab with Fu and Zuchero labs, led by @vedtopkar in our lab. How do molecules make it out to the myelin sheath? For the most expressed protein in oligodendrocytes, an #RNA switch appears to be the answer. Meng-meng's posts explain it best!
Meng-meng Fu@Meng2Fu

Excited to share our new pre-print collab w. @RDasLab! Study led by @VedTopkar brilliant MD/PhD student who used biochemistry and bioinformatics to probe the relationship between Mbp mRNA structure & transport/local translation in oligodendrocytes! biorxiv.org/content/10.110… 1/8

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Keşfet

@CUBoulder @JosephYesselman @RonBreaker @eternagame @chaitjo @UCSanDiego @ShujunHe0717 @UWproteindesign