Sara Hetzel

1/2 The presence of extraembryonic cells in the developing gut has long puzzled scientists. @BatkiJulia (l) and @hetzel_s (r) (#Meissner lab) now gained new insight into the fate and molecular characteristics of these cells. @NatureCellBio Read more: molgen.mpg.de/4717564/

🧬 The placenta's DNA is strange: its methylation patterns are scattered throughout. This is the result of two enzymes that normally work in their respective pens but compete in the placenta, as @hetzel_s @RahaWeigert show in @NatureCellBio. #Meissner Lab molgen.mpg.de/4621109/news_p…

☕️NEW ONLINE: Meissner, Smith & co show that an antagonistic relationship between DNA methyltransferase and Polycomb activity is globally responsible for the maintenance of intermediate methylation levels observed in trophoblast stem cells. doi.org/10.1038/s41556…

Excited to share our work discovering a dynamic antagonism between #DNMT3B and #Polycomb that maintains the placental epigenome. Check out @RahaWeigert thread for more details 👇👇 @MPI_MolGen

🚨!!!Preprint Alert!!!🚨 I am super-delighted to share our work co-led with @adrianobolondi describing the discovery and characterization of a novel lncRNA, LNCSOX17, a key regulator of human definitive endoderm. #Meissner Lab @MPI_MolGen. A🧵1/11 biorxiv.org/content/10.110…

Very excited to share the first piece of work from my PhD with @VahidAsimi @henri_niskanen @chri7stina @hetzel_s @dhnisz out today in @NatureGenet nature.com/articles/s4158… @MPI_MolGen

Our review on new opportunities offered by single-cell technologies for investigating epigenetic regulation during mouse development is out today in @sciencedirect! A team effort with @helenekretzmer and Alex Meissner @MPI_MolGen. A short thread🧵 sciencedirect.com/science/articl…

This work would not have been possible without the work and dedication of my wonderful colleagues and collaboration partners @AL_Mattei, @helenekretzmer, @CMullighan, Alex Meissner and many others!

We also show that CpG island hypermethylation levels in T-ALL patients span a wide range and highlight a role of #TET2 and #DNMT3B in shaping this landscape. #CancerEpigenetics

Excited to share my PhD work now out @NatureCancer! We explored the methylome of acute lymphoblastic #leukemia and found that unlike the classic global hypomethylation found in tumors, ALL exhibits strikingly high genome-wide #DNAmethylation levels. nature.com/articles/s4301…

Outstanding work by my brilliant colleagues who spent many months collecting and summarizing the key pieces to take us on a journey through the history of DNA methylation research. A must-read for anyone in the field and beyond.

@S_Grosswendt @ERC_Research @berlinnovation @ChariteBerlin @BIMSB_MDC @MDC_Berlin Congratulations!

We have been awarded an #ERCStG! Many thanks to @ERC_Research, the panel & reviewers, and great colleagues for their valuable support @berlinnovation/@ChariteBerlin/@BIMSB_MDC/@MDC_Berlin The grant will fund our single-cell research on cell interactions and their communication.

@anshulkundaje Our lab has looked at the KOs of different epigenetic regulators with scRNAseq wrt transcriptional changes, changes in cell state proportions and developmental delay nature.com/articles/s4158…

Can the twitterverse point me to papers that analyze scRNAseq data before and after a gene knockout in other to understand differential effects accounting for changes in cell state and cell proportions? 🙏

🎉 SeqAn 3.1.0 released 🎉 We are happy and proud to announce a new release of the modern #CPP library for sequence analysis. Find out more about it at seqan.de/release/2021/1… or check it out right away github.com/seqan/seqan3/r…. Many thanks to all contributors and supporters.

Thanks to the team @SeqAnLib for providing such an efficient framework for the development of biological sequence analysis tools with #cplusplus. RLM is available via GitHub: github.com/sarahet/RLM

Happy to present the first work of my PhD: RLM, a tool that enables efficient computation of read-level #DNAmethylation metrics from bisulfite sequencing data with @PayGiesselmann, @KnutReinert, Alex Meissner and @helenekretzmer academic.oup.com/bioinformatics…

🚨 #Job Alert! Computational #PhDposition (2/2): investigate the role of #epigenetics during development & regeneration, with cutting-edge HT technologies, incl #scRNAseq data at the #MeissnerLab Join us & apply for your #PhD in Berlin until July 21! 🔗 nature.com/naturecareers/…

🚨 #Job Alert! Computational #PhDposition (1/2): investigate #epigenomics in #cancer and development, using cutting-edge high-throughput technologies at the #MeissnerLab. Join us & apply for your #PhD in Berlin until July 21! 🔗 nature.com/naturecareers/…

Beautiful methylation pearl by Chuck Haggerty, @helenekretzmer, @chri7stina, @AbhiSampKumar, @AL_Mattei, N Bailly, @RahaWeigert & others on the "secret life" of Dnmt1 at #IAPs (as Chuck would say!). Congrats my friends! #MeissnerLab @MPI_MolGen @NatureSMB nature.com/articles/s4159…

Check out the newest publication from our lab! Congratulations @helenekretzmer