Longevity Foresight

Sinclair is back! @davidasinclair Podcast Lifespan is on season 2 m.youtube.com/watch?v=rXLCug…

@biogerontology May good luck favor us.🙏

My AI just analyzed the data from all super centenarians (>110 yo) and found the most important common feature that drove that extreme longevity. They did not exercise, diet, or sleep. They were all very lucky. Luck is the ultimate geroprotector, my friends.

@rand_longevity Optimizing mitochondrial function can reduce the aforementioned risks.

you need to avoid these 4 if you want to live a long life - cancer - dementia - heart disease - diabetes

This is what 97 years of biological decay looks like in one minute. We've mapped the human genome, landed rovers on Mars, built AI that writes poetry. We still accept this as normal. It doesn't have to be.

@chiidex27 It is true that she runs and does Pilates every day, but the light-based treatments and growth hormone supplements are the real hidden variables?

ngl kim kardashian's longevity needs to be studied for real

@rand_longevity Strength training is the closest thing to a longevity drug we have ever found.👀

do you focus on cardio or lifting?

3/3 Backed by titans like Peter Thiel, this profit-driven scheme is being disguised as "bodily autonomy." This isn't a sports revolution; it's a stress test on society's bottom line. The real crisis: When chemical "enhancement" becomes a hidden baseline for workplace and social competition, can you afford to stay "natural"?

2/ So, capital wrote the perfect 3-step commercial script: 1️⃣The Game: Pay athletes to break world records using peptides and steroids under "medical supervision." 2️⃣The Endorsement: Use these records to tell the world these banned substances are actually safe and effective. 3️⃣The Sale: Launch a platform to sell the exact same drugs to ordinary people terrified of aging.

.$1.2B valuation. 50 athletes allowed to take any drugs they want to compete. 🧗 The @enhanced_games opening in Vegas this month looks like a sports rebellion against anti-doping rules, but it’s actually the most expensive product launch in history. Longevity capital has finally found the ultimate fast-track to bypass clinical trials and dump anti-aging drugs on the mass market. 🧵👇

@Outdoctrination So fat storage could be a survival signal, not just a bug?

Calorie restriction can increase lifespan by ~40% - but a stunning study showed that it's NOT because of fat loss or insulin sensitivity. In fact, the animals who were the fattest actually lived the longest! (🧵1/8):

@forallcurious but how do we avoid cancer?

🚨: Researchers managed to reverse the biological age of human skin cells by up to 30 years, effectively turning 53-year-old cells into 23-year-old cells, through a technique called partial cellular reprogramming.

First drug ever shown to lengthen telomeres in a randomized trial. Henagliflozin, a diabetes drug, for 26 weeks. Results: - Treatment group: 90.5% had longer telomeres - Placebo group: 65.6% - Difference: statistically significant, p<0.01 This isn't a supplement study with 12 people. It's a randomized placebo-controlled trial of a drug millions already take for blood sugar. Telomere shortening is one of the 12 hallmarks of aging. Every decade, your telomeres lose about 14% of their length. This is the first time a pill has reversed that trajectory in a controlled experiment. SGLT2 inhibitors already extend life in heart failure patients. Now we might know one reason why.

@beffjezos details pls🤔

AI just upgraded the human genome, increasing our healthspan 5x

@rand_longevity If it's better than my current one, sign me up👀

would you let nanobots replace your immune system?

Laugh loudly!

Mitochondrial Enhancers Master List (refined from @Outdoctrination ): ☆ Taurine: 3-6g/day; sources: meat, seafood ☆ MitoQ: 10-20mg/day; sources: supplement (targeted CoQ10) ☆ PQQ: 10-20mg/day; sources: supplement, kiwifruit/parsley (trace) ☆ CoQ10: 100-300mg/day; sources: organ meats, fatty fish ☆ Urolithin A: 500-1000mg/day; sources: supplement (from pomegranate/berries via gut) ☆ Lipoic acid: 300-600mg/day; sources: spinach, broccoli, organ meats ☆ Creatine: 3-5g/day; sources: red meat, fish NAD+ boosters (NR/NMN/Niacinamide): 250-1000mg/day; sources: supplement, meat/yeast ☆ B1 (Thiamine): 50-300mg/day; sources: pork, seeds, nuts ☆ B2 (Riboflavin): 50-400mg/day; sources: dairy, eggs, leafy greens ☆ B3 (Niacin): 50-500mg/day; sources: meat, fish, peanuts ☆ B5 (Pantothenic acid): 100-500mg/day; sources: avocado, chicken, mushrooms ☆ B6: 50-100mg/day; sources: salmon, chickpeas, bananas ☆ Magnesium: 300-400mg/day; sources: nuts, seeds, dark chocolate ☆ Zinc: 15-30mg/day; sources: oysters, beef, pumpkin seeds ☆ Copper: 1-2mg/day; sources: shellfish, nuts, dark chocolate ☆ Sulfur: 500-2000mg/day (MSM or from diet); sources: garlic, onions, eggs ☆ K2: 100-200mcg/day; sources: natto, fermented foods, grass-fed dairy ☆ Ribose: 5-15g/day; sources: supplement, meat ☆ Red/infrared light: 10-20 min/day; sources: sunlight, therapy devices ☆ Caffeine: 100-300mg/day; sources: coffee, tea ☆ Methylene blue: 1-15mg/day (low dose only); sources: supplement This is not medical advice, for reference only. Please consult your doctor or functional medicine expert, and monitor blood markers.

Mitochondrial Enhancers Master List (refined from @Outdoctrination): Taurine: 3-6g/day; sources: meat, seafood MitoQ: 10-20mg/day; sources: supplement (targeted CoQ10) PQQ: 10-20mg/day; sources: supplement, kiwifruit/parsley (trace) CoQ10: 100-300mg/day; sources: organ meats, fatty fish Urolithin A: 500-1000mg/day; sources: supplement (from pomegranate/berries via gut) Lipoic acid: 300-600mg/day; sources: spinach, broccoli, organ meats Creatine: 3-5g/day; sources: red meat, fish NAD+ boosters (NR/NMN/Niacinamide): 250-1000mg/day; sources: supplement, meat/yeast B1 (Thiamine): 50-300mg/day; sources: pork, seeds, nuts B2 (Riboflavin): 50-400mg/day; sources: dairy, eggs, leafy greens B3 (Niacin): 50-500mg/day; sources: meat, fish, peanuts B5 (Pantothenic acid): 100-500mg/day; sources: avocado, chicken, mushrooms B6: 50-100mg/day; sources: salmon, chickpeas, bananas Magnesium: 300-400mg/day; sources: nuts, seeds, dark chocolate Zinc: 15-30mg/day; sources: oysters, beef, pumpkin seeds Copper: 1-2mg/day; sources: shellfish, nuts, dark chocolate Sulfur: 500-2000mg/day (MSM or from diet); sources: garlic, onions, eggs K2: 100-200mcg/day; sources: natto, fermented foods, grass-fed dairy Ribose: 5-15g/day; sources: supplement, meat Red/infrared light: 10-20 min/day; sources: sunlight, therapy devices Caffeine: 100-300mg/day; sources: coffee, tea Methylene blue: 1-15mg/day (low dose only); sources: supplement This is not medical advice, for reference only. Please consult your doctor or functional medicine expert, and monitor blood markers.

Master list of mitochondrial enhancers: ☆ Taurine ☆ MitoQ ☆ PQQ ☆ CoQ10 ☆ Succinate ☆ Pyruvate ☆ Oxaloacetate ☆ Alpha-ketoglutarate ☆ Urolithin A ☆ Red / infrared light ☆ Methylene blue ☆ B1 ☆ B2 ☆ B3 ☆ NAD+ boosters (Niacinamide, NR, NMN) ☆ B5 ☆ B6 ☆ Magnesium ☆ Zinc ☆ Copper ☆ Sulfur ☆ K2 ☆ Ribose ☆ Lipoic acid ☆ Creatine ☆ Pregnenolone ☆ Progesterone ☆ Caffeine Feel free to add any I'm missing...

@Rainmaker1973 I'd need to drink 438,000 cans to lose a year — suspiciously precise, no? 🤔

One can of soda = 12 minutes of lost life expectancy. A research using the Health Nutritional Index has revealed a sobering link between sugary drinks and lifespan. According to the findings, drinking just one can of cola is associated with a 12-minute reduction in life expectancy. Backed by data from the University of Leicester, this figure represents the cumulative metabolic damage caused by high sugar intake — including increased risks of insulin resistance, obesity, heart disease, and type 2 diabetes. It’s not an immediate effect, but rather a reflection of how regular consumption slowly chips away at long-term health. While the “12 minutes per can” headline is designed to grab attention, experts stress that the real danger lies in daily habits. By converting abstract health risks into a concrete measure of lost time, researchers hope to make the long-term consequences of sugary beverages feel more real and urgent. [Stylianou, K. S., Fulgoni, V. L., & Jolliet, O. (2021). Small targeted dietary changes can yield substantial gains for human health and the environment. Nature Food, 2(8), 616–627. DOI: 10.1038/s43016-021-00343-4]

This scientist found nattokinase. At 10,800 FU daily, it reversed arterial plaque in 66.5% of patients over 12 months, with no side effects. The rest of the data is even more insane. Researchers tracked 1,062 people with confirmed hyperlipidemia and carotid artery plaque. These weren't just healthy volunteers. Every person had an ultrasound at the start and another after 12 months of daily nattokinase. The study used two dose groups: 3,600 FU and 10,800 FU per day. The low-dose group saw almost no change in their plaque or lipid markers. Even though it was the same supplement for the same amount of time, the dose made the difference. At 10,800 FU, carotid artery plaque shrank by up to 36%. The arterial wall thickness decreased by 21.7% on average. These are physical, structural changes that doctors measured and confirmed on ultrasound. 77.7% of participants showed measurable improvement in arterial wall thickness. 66.5% showed measurable reduction in plaque size. Improvement rates across all markers ranged from 66.5% to 95.4% for the majority of over 1,000 people, not some few lucky responders. The participants lipid results moved in every right direction simultaneously. - Total cholesterol: down - LDL: down - Triglycerides: down - HDL: up No adverse effects were recorded at any point across the full 12 months. Lifestyle also amplified everything. Participants walking more than 5,000 steps daily responded better than sedentary ones, and those with higher BMI saw larger relative improvements, likely because they started from a higher risk baseline where there was more room to move. The study also tested co-administration. Vitamin K2 and low-dose aspirin taken alongside nattokinase produced a synergistic effect, outperforming nattokinase alone across cardiovascular markers. If you're building a stack, that's the combination the data points to. The researchers found the effective range is 6,000 to 12,000 FU daily. Most supplements in Europe are only 2,000 FU. That's a huge gap. The data shows 2,000 FU does almost nothing to plaque, while 10,800 FU actually shrinks it. All in all, truly an incredible enzyme.