Mitchell O'Connell

646 posts

Mitchell O'Connell banner
Mitchell O'Connell

Mitchell O'Connell

@mitchellrayoco1

Associate Professor, Biochemistry and Biophysics, @urochestermed. RNA-targeting CRISPR / RNA acetylation. An Aussie in 'the land of the free'. Music Nerd.

Rochester, NY Beigetreten Aralık 2015
1.4K Folgt1.3K Follower
Angehefteter Tweet
Mitchell O'Connell
Mitchell O'Connell@mitchellrayoco1·
1/n After an arduous but constructive peer review process, we’re excited to share the published version of this work. Lots of added goodies: science.org/doi/10.1126/sc…
Mitchell O'Connell@mitchellrayoco1

1/8: Super excited to share our latest pre-print from the lab, where in close collaboration with @kellogg_liz lab we show that through some pore behavior, the CRISPR-Cas13-activated membrane protein CRISPR-Csx28 pulls the plug on bacteriophage infection. biorxiv.org/content/10.110…

English
22
23
101
50.6K
Mitchell O'Connell retweetet
Peter Fineran
Peter Fineran@PeterFineran·
New post-doctoral research position available in my Phage-host interactions (Phi) laboratory at the @otago in the Department of Microbiology and Immunology. The project is focused on defences against jumbo phages. Please share and if interested apply using the link below.
Peter Fineran tweet media
English
2
30
62
4.1K
Mitchell O'Connell
Mitchell O'Connell@mitchellrayoco1·
@JasonSynaptic @DouglasYaoDY Still haven't figured out how to unify gravity with quantum theory, the basis set and laws are there, we're waiting, and most importantly the intellect with there. Come on super easy!
English
0
0
1
175
Jason Shepherd
Jason Shepherd@JasonSynaptic·
@DouglasYaoDY LOL..like these tech lords are any smarter than the average Stanford PhD student. This obsession with IQ/smartness by these people is creepy. Most of them made $$ through dumb luck and timing. Why is it so hard to understand that biology is bloody complicated?!
English
3
2
91
3.7K
Douglas Yao
Douglas Yao@DouglasYaoDY·
Peter Thiel said that the lack of progress in biology is partially due to a lack of talent. I think this makes sense. Something about biology's non-technical nature + people's inability to tinker w/biology outside of a lab/PhD make the smartest people select other fields.
English
470
171
3.8K
1.2M
Mitchell O'Connell
Mitchell O'Connell@mitchellrayoco1·
@DouglasYaoDY May be we should just take off the table all the biological advances over the last 50-100 years and live your life. Talk with scientists cracking these problems and you might feel a little whelmed about your intellect
English
0
0
1
89
Mitchell O'Connell
Mitchell O'Connell@mitchellrayoco1·
@anshulkundaje And the sheer sanctimony with this statement is everything that is wrong about this country. We've built up these people to think they're all lone wolf geniuses
English
0
0
1
193
Anshul Kundaje
Anshul Kundaje@anshulkundaje·
Those "smart people" pick other fields because the learning curve to really understand how to model biology is very steep. It is extremely rare that someone can "engineer" their way to make serious progress on most problems in biology as compared to other applied domains.
Douglas Yao@DouglasYaoDY

Peter Thiel said that the lack of progress in biology is partially due to a lack of talent. I think this makes sense. Something about biology's non-technical nature + people's inability to tinker w/biology outside of a lab/PhD make the smartest people select other fields.

English
35
30
479
46.7K
Mitchell O'Connell
Mitchell O'Connell@mitchellrayoco1·
@anshulkundaje Such a terrible take in so many ways. We're technical, it's their sheer lack of understanding the complexity of the system and the dynamics of the system and just the great unsampled unknown of the biological space that our human brains can't fathom. Peter Thiel needs a lesson
English
0
0
1
264
Nuclear Crypto Georgist
Nuclear Crypto Georgist@Crypto_Georgist·
@deserteagle291 @DouglasYaoDY Nope, biology is way easier than physics or chemistry or engineering. Smart people don't care to go through 10 years of bachelor's master's PhD and regulatory hoops to do biology research
English
1
0
0
118
Ben Adler
Ben Adler@ben_a_adler·
🦠🧬Our paper is live @CellCellPress: Genome integrity sensing by the broad-spectrum Hachiman antiphage defense complex authors.elsevier.com/sd/article/S00… Through structural, genetic and microbiological approaches, we show that Hachiman degrades DNA… by sensing low integrity DNA.
English
6
44
119
16.6K
Liz Kellogg ❄️🔬
Liz Kellogg ❄️🔬@kellogg_liz·
I just had a feeling that it would be this year!! A massive congratulations to the most inspirational and deserving scientist I know, my mentor and PhD advisor David Baker!!!! 🍾🍾🍾🍾🍾
The Nobel Prize@NobelPrize

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

English
3
6
214
13.8K
Liz Kellogg ❄️🔬
Liz Kellogg ❄️🔬@kellogg_liz·
Kellogg lab has been growing fast.. and still hiring! We're looking for postdoctoral fellows passionate about cryo-EM, transposons, and protein design. @StJudeStructBio has top notch facilities, including a Krios G4 Cold-FEG.. and still expanding! Know a superstar? maybe you?
Liz Kellogg ❄️🔬 tweet media
English
6
19
95
13.9K
Mitchell O'Connell
Mitchell O'Connell@mitchellrayoco1·
Folks with broad interests in any area of biochemistry and biophysics, including structural and computational biology as well as metabolomics and genomics should consider applying. We will consider all applications on their merit!
English
0
0
1
292
Mitchell O'Connell
Mitchell O'Connell@mitchellrayoco1·
My department is hiring! We’re looking for faculty in the department of Biochemistry and Biophysics at the University of Rochester. As I can attest, Rochester provides a highly supportive and collaborative environment and is a great place to work/live: jobs.sciencecareers.org/job/662300/ten…
English
2
6
15
2.4K
Mitchell O'Connell retweetet
Brady Cress
Brady Cress@bradyfcress·
Excited about phage functional genomics, phage engineering, & microbiome editing? The Cress Lab @UCBerkeley @igisci is hiring postdocs in these areas! Come chat w/ me @VoM_2024 & don't miss my presentation w/ @ben_a_adler in the SynBio session Fri @ 11:20am. Retweets appreciated!
English
0
22
46
8.2K
Jason Shepherd
Jason Shepherd@JasonSynaptic·
No more assisting or associating...I'm now officially just "Professor" 🎉 Thanks to my lab past and present, who's hard work made all of this possible! Also thanks to a very supportive Chair, Monica Vetter, and department @UUtah @UUNeurobiology!
GIF
English
89
4
445
34.3K
Mitchell O'Connell
Mitchell O'Connell@mitchellrayoco1·
Big congratulations to @ammolinavargas graduating with his PhD, not to mention all the accolades along the way including the Leadership Award for Excellence in Equity and Inclusion bestowed at graduation. We're all very proud of all your accomplishments and we're gonna miss you!
Mitchell O'Connell tweet media
English
0
0
17
1.4K
Mitchell O'Connell
Mitchell O'Connell@mitchellrayoco1·
@andrewwhite01 ha! particularly the gammaS version (the image you shared), not gonna lose interest (hydrolyze) before the end of the conversation.
English
0
0
0
240
Andrew White 🐦‍⬛
Andrew White 🐦‍⬛@andrewwhite01·
New product idea - ChatGTP - where you can chat with an LLM that thinks it is Guanosine-5'-triphosphate and learn facts about metabolism
Andrew White 🐦‍⬛ tweet media
English
4
1
37
5.9K

Entdecken

@otago @Wagnerlab_RNA @JasonSynaptic @DouglasYaoDY @anshulkundaje @Crypto_Georgist @deserteagle291 @NMITaylorLab