osk

449 posts

osk banner
osk

osk

@ogsvg

all roads lead to Christ. Building https://t.co/HQk2MxSNHk - the pepwiki.

Beigetreten Eylül 2015
43 Folgt73 Follower
Angehefteter Tweet
osk
osk@ogsvg·
Peptides are not miracle drugs! I built a site that grades them against the data. 46 peptides. 419 citations. community-voted tier list. not medical advice. not selling you anything on this site. I love peptides and there's too much BS on socials about em... go see the information for yourself. reptides.co
English
0
0
0
62
Reta
Reta@Biomaxxer0·
Unfortunately biohacking is not cheap and you need money to buy the supplements, roids and nootropics that will end up making you way more money (spend money to make money) So here’s what you start with to maximize ROI: • A blood panel. This is critical. CBC, CMP, lipids, liver enzymes, homocysteine, CRP, hormones (free & total T, high sensitivity e2, tsh, free t3/t4, prolactin) - most essential. This will run you ~$250. Worth every penny. • Fix any micronutrient deficiencies first. That’s why this is second on the list. • Run a cycle of 9-Me-BC and dihexa. Repair your baseline dopaminergic tone while also literally becoming smarter. Peak. Pretty cheap; ruo.bio code BIOMAX has you covered After doing the above, which will cost ~$400 total, you’ll be significantly more prepared to make enough income to *actually* start biohacking - running AAS cycles, stacking niche nootropics, 30 supplements a day, high quality food, etc If you can’t save $400 to start your journey, you’re ngmi
Reta tweet mediaReta tweet media
English
3
3
100
5.8K
osk
osk@ogsvg·
No large independent (non-Harding lab) studies confirming Dihexa’s direct HGF/c-Met binding/activation without citing the retracted work appear in the literature. The cancer risk remains theoretical (no human data, no confirmed cases from Dihexa use), but the pathway concern is why many sources still advise caution, especially in people with cancer history or predisposition. It was literally retracted last year. Gonna be hard to find studies that don’t link to the original Harding lab. Keep pushing this stuff maybe you’ll make a few bucks 😭
English
1
0
0
55
Reta
Reta@Biomaxxer0·
> proven cancer advancing peptide Wrong, the study you’re (probably) referring to on Dihexa was falsified, and later retracted Not only that but for it to be actually oncogenic it would have to actually bind or activate c-Met… which it literally doesn’t Yeah bro getting a boo boo and having endogenous healing factors respond to repairing the damage causes cancer Braindead take. Read more literature
English
1
0
0
177
osk
osk@ogsvg·
@bryan_johnson Interdasting - why not tesamorelin? It stimulates gh release closer to your bodies natural pulses instead of your pituitary running hot for 6-8 days. Tesa half life is ~30 minutes Cjc NO Dac is 6-8 days. Could disrupt your natural gh rhythm when you get off.
English
0
0
2
576
Bryan Johnson
Bryan Johnson@bryan_johnson·
Everyone's injecting peptides. Almost no one is measuring what they actually do. I'm stacking two peptides with opposite side effects and testing whether the downsides cancel while the benefits don't. Tirzepatide didn't work for me. I'm already top 1% on glucose control and body composition, so the marginal upside was small. And even at 20% of the starting dose (0.5 mg/week), my resting HR climbed 2–3 bpm. Even granting it might return to baseline in a couple weeks, not worth it. So I'm testing whether I can stack two peptides with opposite side effects and get the best of both worlds. Tirzepatide: metabolic optimization, yet raises my HR and can disrupt my sleep. CJC-1295 (a GHRH agonist that drives my own GH and IGF-1): growth and repair, but can blunt my glucose control and cause insulin resistance. Opposite vectors on autonomic tone. Opposite vectors on glucose. On paper, the side effects cancel but the benefits don't. That's my hypothesis. Now I'll measure it. Two CJC-1295 variants on the table: • DAC: weekly injection, extended half-life • No-DAC + Ipamorelin: daily, before bed The peptide community leans no-DAC, assuming it better preserves pulsatile GH release, with fewer side effects. However, the published data on DAC is better than the public consensus gives it credit for: sustained GHRH signaling without abolishing pulses, 7.5x overnight GH trough, >150% IGF-1 increase after two weekly doses at 30 µg/kg. I'm starting with DAC, weekly dosing of the long-acting version, and monitoring side effects closely. If they're intolerable, I'll switch to no-DAC + Ipamorelin, daily. Here’s my protocol, taking it easy on the dose, since DAC peptides are long acting: Week 1 1.2 mg CJC-1295 DAC Week 2 2.4 mg (or switch to no-DAC + Ipamorelin if side effects demand it) Weeks 3 and 4 2.4 mg CJC-1295 weekly + 0.25 mg tirzepatide, twice weekly Measuring everything: • Weekly blood: IGF-1, GH, GHRH, fasting glucose, insulin, HOMA-IR, ApoA1, ApoB, prolactin, cortisol • Continuous CGM across all 4 weeks • Continuous core body temp (eCelsius capsule), weekly • Sleep, HR, HRV: 24/7 I'll post results as they arrive.
Bryan Johnson tweet mediaBryan Johnson tweet media
English
140
54
1.8K
198.5K
BowTiedYukon
BowTiedYukon@BowTiedYukon·
I’ve fallen deep down the MOTS-c rabbit hole. I’ve become a big fan so I’ve been doing more research into it If I was going to stack anything with a GLP to try to get the most out of both & which can work in tandem with each other it would be MOTS-c MOTS-c targets your mitochondria which are your cells energy systems. It can also improve insulin sensitivity & push the body toward better glucose utilization. It also increases fat metabolism and exercise performance. Basically it will optimize how your body uses energy GLP’s (semaglutide, tirzepatide, retatrutide, cagrilintide) Slow gastric emptying making you feel full longer reducing your appetite significantly. They improve blood sugar control & are clinically proven to help with weight loss. Basically they help you eat less & stabilize your blood sugar The potential benefit of combining the two could be enhanced fat loss (theoretical synergy) GLP-1: Reduces calorie intake MOTS-c: May improve how fat is burned Combined: less food intake & better utilization of the food you take in Better insulin sensitivity since both can improve glucose handling via different pathways this could mean more stable energy and fewer blood sugar swings One downside of GLP’s is metabolic slowdown during weight loss. MOTS-helps maintain mitochondrial activity which means potentially less “metabolic adaptation” & a preservation of metabolic rate Some people report fatigue on GLP’s MOTS-c is often studied for cellular energy support which may offset the fatigued feeling leading to improved energy levels MOTS-c is also researched for exercise performance support. Potentially helping maintain training intensity when cutting weight If you skipped all that here’s the abbreviated version. The combination of the two makes sense in theory GLP’s for appetite control MOTS-c for metabolic optimization It’s up to you to do your own research
English
39
8
218
20.3K
osk
osk@ogsvg·
@JohnGoldman The problem with a business like this is the barrier to entry is so low and the risk is so high that not many legitimate entrepreneurs will enter. Few are legit many are grifters. Rarely anyone has actual QC. And COAS are not quality control lol.
English
0
0
1
17
Michael Albert, MD
Michael Albert, MD@MichaelAlbertMD·
You don’t get to question vaccines while taking research-grade peptides. Vaccines: tens of thousands of patients, randomized trials, decades of safety data. Peptides: sometimes zero human studies. Pick a lane. Stop the hypocrisy.
English
66
5
58
5.8K
osk
osk@ogsvg·
@Adityalch you might like reptides -- doesnt compete with you, basically the pepwiki. 419 clinical trials and 272 claims evaluated
English
1
0
1
30
Aditya Lalchandani
Aditya Lalchandani@Adityalch·
Sigh. In Bali right now and the number of "coaches" shilling peptides to their clients as if they understand them. Table next to me: "Girl you totally need to get on wolverine stack!" Burn it all. At some point, you're just attempting to practice medicine without a license.
English
3
0
13
1.4K
osk
osk@ogsvg·
you can now search for what each peptide does in reptides... for example you can ask - what does Ipamorelin do? And reptides will generate a prebaked answer... not an ai. i painstakingly tried to hit 500 most common questions people will ask and made claude give a response for all those... took about 2 hours lmao
English
0
0
1
53
osk
osk@ogsvg·
With all the hype about retatrutide online - I wanted to give people the chance to see the data... and tbh it holds up quite well.. reta is the most powerful GLP to date. Read about it below reptides.co/p/retatrutide
English
0
0
1
62
osk
osk@ogsvg·
theres a reason why - 1980s sleep trials: multiple small-to-medium human studies in insomnia, reporting benefits in some cohorts but failing to replicate consistently. DSIP is not what people think it is... not a miracle sleep agent. It was abandoned in clinical trials because it's effects on sleep couldn't replicated consistently
English
0
0
0
102
Hunter Williams
Hunter Williams@HunterEsoteric·
Nobody talks about DSIP and it might be the most underrated sleep peptide out there. Here's how it actually works DSIP — Delta Sleep Inducing Peptide → Crosses the blood brain barrier → Binds to specific receptors in the hypothalamus → Increases delta wave activity during sleep Delta waves are what happen during deep sleep. Deep sleep is when: → Growth hormone is released → Cellular repair happens → Memory consolidation occurs → Cortisol resets for the next day Most sleep supplements work by sedating you. DSIP doesn't sedate. It induces the specific brainwave pattern your body needs to actually recover. You've been counting hours of sleep. You should have been counting delta waves.
English
15
4
104
8.4K
osk
osk@ogsvg·
@kalos21million That means a ton coming from you dude. Thank you.
English
0
0
1
13
kalos
kalos@kalos21million·
@ogsvg I like this. Very aligned vision with some clear differences.
English
1
0
0
45
osk
osk@ogsvg·
I don’t think there is another website like Reptides - I went full autist mode. I have a total of 419 clinical trials cited across 46 peptides. About 8 trials per peptide. On top of thousands of x and reddit posts. Your one stop info shop for everything peptides
English
1
0
0
68
osk
osk@ogsvg·
honestly im so proud of reptides i spent so much time on this just so people have info about peptides... for free!! and you get to vote on peps to move up or down the tier list...
osk tweet media
English
0
0
1
50
osk
osk@ogsvg·
@brentlajeunesse Hope the only test oil you have is MCT. Lots of cyp is grapeseed oil 🤮
English
0
0
0
29
Brent LaJeunesse
Brent LaJeunesse@brentlajeunesse·
I’ve been on testosterone since my numbers declined in my mid-40s, and I’m not looking back. Mental clarity, energy for activity, sex drive, and muscle retention are all firing on all cylinders. It may not extend your life by 20 years, but it will absolutely give you a higher quality 20 years. If you’re feeling off, have foggy brain, dragging through the day, lower drive, or losing strength despite training, don’t just accept it as “getting older.” See your doctor and get your levels checked. It changed the game for me. What about you? Have you had your T levels tested lately? And it’s not just for men. The ladies can benefit too! Live Savage! —B
Brent LaJeunesse tweet media
Greg O'Gallagher@gregogallagher

If a drug came out that unlocked more muscle, made you feel younger, and added 20 years to your life would you take it? Or stay natural?

English
26
6
140
31.6K
osk
osk@ogsvg·
everyone's "i built this with ai" post is slop. here's a real one. 9 hours today on reptides v201 → v220. claude does the code + drafts. chatgpt for claims. gemini pulls sources. i get final say on everything. shipped today: 135 new studies integrated, FAQ on every peptide page, google indexing fixed, 46 link-preview cards. no affiliates.
English
0
0
1
60