Kunal Rai

@may_daher @HusseinAbbasLab @abhinavjain_phd Congratulations to all authors for this important work, including @anandkamalsingh from my group.

@raikunal @HusseinAbbasLab Congratulations to Bijender Kumar and Anand Singh! Huge thanks to all our collaborators @raikunal @HusseinAbbasLab @abhinavjain_phd

Excited to share our manuscript published in @ScienceTM, where we describe a novel NK immune evasion strategy in AML. We found that #BATF is a key transcription factor driving epigenetic reprogramming in NK cells in AML. This TF is induced by the canonical TGF-β/SMAD pathway and leads to persistent NK cell dysfunction. This dysfunction can be prevented by deleting BATF or TGFBR2 upstream, but once established, it cannot be reversed. Designed to overcome epigenetic scarring, we look forward to bringing this novel CAR-NK cell approach to the clinic to improve outcomes for AML patients. @mdandersonnews @lab_rezvani @bijender2050 #AML #NK #CRISPR #epigenetics #BATF

Join us at #FoGBoston for insights from @raikunal (Associate Professor & Scientific Director, @MDAndersonNews Epigenomics Therapy Initiative) on his work surrounding the role of #epigenetic changes in cancer progression. More info here: hubs.la/Q022tvn70 #cancergenomics

Honored and thrilled to receive Young Alumni Achiever Award 2023 from my alma mater, Indian Institute of Technology, Kharagpur @IITKgp

@IITKgp @EduMinOfIndia @dpradhanbjp @Drsubhassarkar @PMOIndia @IITKgp Thank you for the honor.

Great achievers are old enough to be wise & young enough to believe they can change the world @IITKgp is delighted to announce Young Alumni Achiever Awardees 2023. Heartiest Congratulations! @EduMinOfIndia @dpradhanbjp @Drsubhassarkar @PMOIndia

Our new study shows NRF2-driven enhancer reprogramming contributes to chemotherapy resistance in head and neck cancers, providing rationale for targeting NRF2 to overcome cisplatin resistance. Led by @earslan_tamu and Dr. Abdullah Osman. @MDAndersonNews aacrjournals.org/clincancerres/…

Recently got my trophy for Potu N Rao Award for Excellence in Basic Science 2022. Many thanks to Division of Cancer medicine @MDAndersonNews for the recognition. I owe to this to the tireless efforts of the present and past trainees in my lab.

@RockefellerUniv It's so sad to hear. His work has had tremendous influence on many of us including my own career. Most importantly, he was such an amazing human being and so easy to talk to. RIP!

It is with heavy hearts that we announce the passing of our beloved colleague and friend, C. David Allis. Aside from his groundbreaking contributions to biomedical science, David will be remembered for his warmth, humility, and relentless optimism.

Happy to share our Review on chromatin state dynamics and computational tools to explore differential CS in normal vs. cancer cell | @ Briefings in Bioinformatics | w/ @aayushraman | academic.oup.com/bib/advance-ar… | @PMResearch_UHN @broadinstitute @MDAndersonNews #epigenomics #chromatin

Our preprint on epigenome reprogramming in R and NR melanoma patients treated with ICB suggests an enhancer biomarker and BETi+aPD1 combo. Great collaboration with @manoliskellis @gmboland @MMattohti @tangming2005 @JenWargoMD @dliu_ccb @MDAndersonNews biorxiv.org/content/10.110…

Preprint @raikunal @MDAndersonNews with @gmboland @MGHCancerCenter @manoliskellis @MIT: Enhancer Reprogramming in Melanoma Immune Checkpoint Therapy Resistance biorxiv.org/content/10.110… Nice data from high throughput profiling of clinical samples to functional perturbation study.

Comparable tumor immune microenvironment in human glioblastoma & murine model: buff.ly/3OdgOk3 @Zamler_Brain @Jianhu_Neural @draettag @HeimbergerAmy @LurieCancer @BrainTumorInst @MDAndersonNews @swatowic @raikunal @tcellsrus @lmks91 @cinziakas @KristinHuntoon @KatTomcat1

Our collaborative work with Joe Ludwig on DSRCT,showing AR as a therapeutic target that functions through epigenome reprogramming, appeared today in @NatureComms . @MMattohti @MDAndersonNews nature.com/articles/s4146…

Thankful to CPRIT for their support of our research. @MDAndersonNews

BREAKING NEWS: CPRIT announces 74 new grants for over $112 million to expand innovations in cancer research and prevention in Texas. Check out the release for the entire list of awards. #CPRIT #TexansConquerCancer ow.ly/1AQ050HWOem

New research identifies mechanisms behind how fasting can reduce the negative effects of high-dose chemotherapy and radiation therapy: fal.cn/3kqFD @raikunal @TaniguchiMD #EndCancer

Chris Terranova, Kristina Stemler, Kunal Rai, Helen Piwnica Worms and collaborators - Reprogramming of H3K9bhb at regulatory elements is a key feature of fasting in the small intestine cell.com/cell-reports/f…

Collaborative work with @HusseinAbbas01 @Daver_Leukemia @IamLinghua online now. @KatTomcat1 @praveenbarrodia from my lab contributed significantly to this work. Congrats to all! nature.com/articles/s4146…

Congrats to @HusseinAbbas01, my postdoc Dapeng and the team | Single cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy ⁦@Daver_Leukemia⁩ ⁦@raikunal⁩ @MDAndersonNews⁩ nature.com/articles/s4146…

We are looking for two motivated and talented 'Senior Research Scientists" with expertise in protein biochemistry and CRISPR/Cas screening at MDACC Epigenomics Initiative (METI). Biochemist position: bit.ly/3lAPFMc Biology Position: bit.ly/2YK7Nda

@nicholas_navin Congratulations Nick!

Very honored to receive the Grady Saunders Distinguished Professorship at MD Anderson, thank you for supporting my career at every stage!