Systematic Trading Fun 🇨🇭

Pediatric long COVID is characterized by myeloid CCR6 suppression and immune dysregulation Very interesting Spanish study in preprint! #LEONARDI_effect in CHILDREN! ➡️Chemokine receptor CCR6 on the surface of myeloid cells, which include monocytes, macrophages, and dendritic cells, play a key-role in the innate immune system. ➡️Now this study shows CCR6 expression on myeloid cells are SURPRESSED and serves as the most discriminative biomarker for pediatric long COVID, reflecting profound immune dysregulation, including altered innate immunity, lymphocyte overactivation, and impaired SARS-CoV-2 humoral responses, that persists months after acute infection in affected children and adolescents. ➡️This study is highly relevant as one of the first to identify suppressed CCR6 expression on myeloid cells as a strong, discriminative biomarker (79% accuracy) for pediatric long COVID, shedding light on persistent immune dysregulation in children and filling a critical gap in understanding its mechanisms compared to adults. ➡️What this likely means biologically: - The reduced CCR6 on myeloid cells points to a form of innate immune dysregulation persisting months after the initial infection. - It could impair the proper migration or function of these cells to resolve inflammation, contribute to ongoing low-grade immune activation/misbalance (e.g., altered dendritic cell/monocyte subsets observed in the study), or reflect broader exhaustion/altered signalling in the myeloid compartment. - This ties into the study's overall picture of dysregulated innate immunity combined with overactive lymphocytes and weaker antibody responses in affected kids, suggesting myeloid changes (like CCR6 downregulation) as a core driver of why some children develop prolonged symptoms. ‼️Early claims that SARS-CoV-2 poses essentially no harm to children were dangerously oversimplified and wrong, the virus does cause real, sometimes severe or prolonged damage in kids, including acute complications like MIS-C, rare but tragic deaths, and persistent long COVID in a substantial group, with now measurable immune dysregulation that can impair development and quality of life, maybe even life-long! Makes me ANGRY, very ANGRY! FYI: @fitterhappierAJ insight.jci.org/articles/view/…

@RealAnitaWhite @DonEford @Friesein I actually just saw a report on that from Jefferies yesterday, for the US. Don’t have the global numbers, though. As of Feb. 6th, Novavax has ~227k administrations on the year, which makes up 1.1% of the 20.5M COVID vaccines

In 2020 I published a paper arguing that there likely was an element of CD8 T cell death in Covid. For the following years, I was met with overall antipathy from many professors for claiming covid was harming T cells. Now, a new publication highlights persistent T cell attenuation. sciencedirect.com/science/articl… I was punished the sin of being correct on my matter of expertise before I had done a postdoc or graduated medical school, and for an opinion contrary to many individuals who had incentives to downplay covid or a lack of scientific imagination. My claims were swiftboated, people tried to put words in my mouth, strawman me, and attack me personally. Vincent Raccaniello said the claims covid was harming T cells was "twitter science." Vincent Rajkumar, the editor of Blood, said it was "nonsense." Carlos Del Rio, a professor of Infectious disease said, "I'm exhausted reading such claims from non-immunologists." One immunologist and nephrologist at the Francis Crick institute, Rupert Beale, claimed that cranks were being taken as legitimate sources while I was a medical student. An immunologist at Novartis, Andrew Croxford, mocked me as if I was a self-described 'galileo,' after Zeynep Tufekci referred to me saying, 'not every crank is Galileo.' I'm sorry the truth had to come from someone who lacked pretense, completed fellowships, and several decades of life. It should have been enough to have published in the field, understood the issue, and have been able to articulate the rationale. There were many attacks to my livelihood and my affiliated entities, accusing me of fear-mongering. and writing pseudo-science. One group of Professors even saw it fit to write that the T cells were "Fit and Happy" following breakthrough covid. I have never seen in history someone lampooning an individual with the title of a scientific journal article. Their aim was total demoralization. Having been subjected to this, I believe it is a very unique experience, to be met with derision from 1) Established professors 2) Journalists at the New York Times 3) Journal publications A recent article in the BMJ highlighted how eminent immunologists are starting to believe Covid has harmed population immunity. I was included in the piece until the editor said they needed to avoid the controversy to save face, thereby erasing my advocacy and the absolutely unethical conduct of people who had fixed to attack me. Regardless, this is a significant result. With multiple covid infections, the issue becomes even more relevant. Please keep up to date with vaccinations and avoid covid with use of an N95 if you want to keep your immune system healthy.