fleemanlab.bsky.social

418 posts

fleemanlab.bsky.social

fleemanlab.bsky.social

@FleemanLab

Assistant Professor at the University of Central Florida College of Medicine studying drug resistant Klebsiella pneumoniae.

Joined Temmuz 2016
264 Following314 Followers
Tania Wong
Tania Wong@TaniaWong88·
Truly honored and thankful to receive an R35 MIRA grant from NIGMS - grateful for the support and the opportunity to pursue our research on diet-mediated immunometabolic responses in the context of infectious diseases.
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Despoina  Mavridou
Despoina Mavridou@bondSSbond·
Our review on disulfide formation is out! Since the discovery the DSB system ~35 years ago, we have made great steps in understanding its role in processes like virulence and #AMR. In loving memory of my supervisor Stuart Ferguson. @nikikaderabkova Link: #sec0037" target="_blank" rel="nofollow noopener">sciencedirect.com/science/articl…
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fleemanlab.bsky.social@FleemanLab·
Surface display library day at @UCF We are excited to clone our peptide library into colistin resistant Kleb @KlebClub 😊 Pictured here is Christina DeBarro and Gaby Echeverria getting ready to collect colonies!
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fleemanlab.bsky.social@FleemanLab·
So excited to be in Vienna for #ESCMID2025 where I will be giving a talk on how our peptides can disrupt K. pneumoniae biofilms. If you are around this Tuesday come check it out!!!
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fleemanlab.bsky.social@FleemanLab·
Great weekend at #FLASM2025! I was so pleased to see my students work was well received! They were so excited to present their work!
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Ammar Zafar
Ammar Zafar@az1980micro·
Our study appearing in @NatureComms showing the importance of the T6SS of Klebsiella pneumoniae in gut colonization. We combined tn-seq with metagenomics and identified new microbiota targets and T6SS regulators. nature.com/articles/s4146…
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Caity Holmes
Caity Holmes@CL_Holmes·
I'm excited to announce our latest publication! We teamed up with @KHullahalli to barcode Klebsiella and ask basic questions about bacteremia pathogenesis: 1) how are bacteria shared between sites and 2) which host and bacterial factors influence dynamics? nature.com/articles/s4146…
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fleemanlab.bsky.social
fleemanlab.bsky.social@FleemanLab·
Check out the most recent advances by the de la Fuente group using AI to change the face of antimicrobial discovery!
César de la Fuente@delafuentelab

Antibiotic discovery is notoriously hard and slow. What if we could change that by optimizing antibiotics on the computer? Introducing APEXgo, our latest AI model, which integrates a transformer-based variational autoencoder with Bayesian optimization to design novel antibiotics. Unlike traditional AI approaches, which rely on fixed databases of known molecules, APEXgo explores uncharted sequence space, proposing entirely novel peptides that have not been seen before. We put APEXgo to the test with a bold challenge: could it design optimized compounds with antibiotic activity using templates from extinct organisms like woolly mammoths and giant sloths? 🐘🦣 The results? 🤯 · 100 peptides were synthesized and characterized for antimicrobial activity, mechanism of action, secondary structure, and cytotoxicity. · APEXgo achieved an 85% experimental hit rate. · 72% success in improving activity against dangerous Gram-negative pathogens —a major challenge. · The antibiotics designed by APEXgo were effective in mouse models, even outperforming polymyxin B (a last-resort antibiotic). This work represents the first ground-truth experimental validation of generative Bayesian optimization in any setting, and we are excited that its debut application is in antibiotic discovery. With APEXgo, we have entered an era where AI accelerates antibiotic discovery and explores molecular diversity at digital speed. #AI #Antibiotics Huge congratulations to my amazing Team and collaborators on this achievement: @mdt_torres, Yimeng Zeng, Fangping Wan, Natalie Maus, and Jake Gardner @Penn @PennMedicine @PennEngineers Link to the paper: biorxiv.org/content/10.110…

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Salvador Almagro-Moreno
🚨We have a "Scientist" position in my lab at @StJude 👉This position is stable and not dependent on external funding. 🗒️Ideally, the candidate holds a PhD in Microbiology or related and +3 years exp. post PhD. See details in ad. Please kindly retweet! talent.stjude.org/careers/jobs/J…
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César de la Fuente
César de la Fuente@delafuentelab·
Not long ago, discovering antibiotics meant painstakingly purifying compounds from sources like soil—a process longer than earning a PhD, often with limited success. Years ago, we envisioned that by treating biology as an information source and mining it with advanced algorithms, we could revolutionize antibiotic discovery. In my @PLOSBiology article, I summarize our progress over the past 5+ years. Today, my lab can discover hundreds of thousands of new antibiotic molecules in just a few hours—on a computer.
PLOS Biology@PLOSBiology

The rise of #AntibioticResistance calls for innovative solutions; @delafuentelab outlines how biology can be mined digitally using #ArtificialIntelligence as a new paradigm for antibiotic discovery, offering hope in the fight against superbugs #PLOSBiology plos.io/3B3rWP8

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