BIOIntegration

BIOI achieves a #CiteScore of 3.3! We gratefully acknowledge the contributions made by our editors, reviewers and readers and the authors for choosing us! Yet another reason to publish in BIOI! #OpenAccess : bio-integration.org

This study demonstrates that hT2AB regulates the C2 #Microglial subpopulation, guiding protective differentiation in #AlzheimersDisease, providing direct evidence of #therapeutic potential and opening new avenues for #Biomarker development and #TargetedTherapies. #OpenAccess: bio-integration.org/alzheimers-dis…

Our latest cover visualizes the essence of the journal: integration across the biomedical ecosystem. Interlocking puzzle pieces form a human brain, symbolizing how biology, bioengineering, medicine, public health, policy, and industry work together to drive innovation in healthcare. BIO Integration is an international platinum open-access journal dedicated to advancing modern medicine through multidisciplinary collaboration and research. Discover the journal and its latest research: bio-integration.org #BiomedicalScience #OpenAccessPublishing #LifeSciences

This review provides a comprehensive analysis of the therapeutic potential of #Phytochemicals such as #Flavonoids, #Alkaloids, and #Terpenoids in managing #RheumatoidArthritis, highlighting their ability to modulate key pro-inflammatory cytokines like TNF-α and IL-6 via the NF-κB and MAPK signaling pathways to overcome conventional #DrugResistance. #OpenAccess: bio-integration.org/phytochemicals…

This #Bioinformatics study identifies regulatory networks linking ten #Albinism-associated genes to non-skin malignancies, revealing that predicted #miRNAs and transcription factors—specifically associated with #BreastCancer, #HepatocellularCarcinoma, and #PancreaticCancer—govern critical pathways in cell division and #Apoptosis beyond expected cutaneous phenotypes. @ErasmiaR #OpenAccess: bio-integration.org/bioinformatics…

This study uses #SingleCellTranscriptomics to identify C0 Atcayos+ cardiomyocytes that interact with #fibroblasts via Bmp6 and Fgf1 signaling after #IschemiaReperfusion, uncovering pathways that could reduce #fibrosis and help preserve #cardiac function. Read: bio-integration.org/single-cell-om…

This review explores soft, sustainable #wearable #bioelectronics integrating skin-like materials, #hydrogels, wireless analytics, and #AI for continuous monitoring and therapy, while outlining challenges in biocompatibility, stability, regulation, and system integration. @TAMU #OpenAccess: bio-integration.org/wearable-bioel…

This review explores #Bioengineering strategies for modifying #ExtracellularVesicles to enhance their therapeutic efficacy in #Osteoarthritis, while discussing the current limitations and future directions towards clinical translation. #OpenAccess: bio-integration.org/extracellular-…

#TCM-derived #carbondots bridge #CharcoalMedicine and #nanomedicine, offering biocompatible platforms with potential in inflammation, neurological, and metabolic disorders, while challenges in characterization, standardized synthesis, and clinical translation remain. @KingsCollegeLon #OpenAccess: bio-integration.org/traditional-ch…

This review analyzes #LIPUS as a #noninvasive therapy for #PrematureOvarianInsufficiency, highlighting its roles in modulating cell proliferation, #apoptosis and #angiogenesis, while exploring combination strategies and future prospects for restoring #ovarian function. @HKUniversity #OpenAccess: bio-integration.org/lipus-prematur…

The BIO Integration 2025 Reviewer Acknowledgement celebrates the dedication of our peer reviewers, whose interdisciplinary expertise ensures the scientific rigor and clinical relevance of our published research. BIOI Recognition Awards: bio-integration.org/bio-integratio…

Insights into various #ImmuneCheckpointInhibitors (ICIs) -related digestive system adverse events (ir-DSAEs), their symptoms, with discussion into their underlying molecular mechanisms, risk factors, #Diagnosis, and therapeutic strategies. #Hepatitis #GutMicrobiota @smu_medical #OpenAccess: bio-integration.org/irdsaes-checkp…

Using conventional #Ultrasound (CUS) & contrast-enhanced ultrasound (CEUS), this study investigated the #Imaging characteristics of hepatic PEComa and #HCC without high-risk factors, enabling their precise differentiation and supporting appropriate clinical management strategies. #OpenAccess: bio-integration.org/imaging-preope…

This study used #MendelianRandomization to uncover causal links between #indigonaturalis targets and #vascular disorders, including #DeepVeinThrombosis, identifying urate as a partial mediator and providing evidence-based insights into vascular safety for its clinical use. #OpenAccess: bio-integration.org/vascular-toxic…

This study shows that a #DeepLearning #ultrasound model (swin_transformer) accurately distinguishes benign from malignant #adnexal lesions in #Postmenopausal women and significantly boosts diagnostic performance of junior #Radiologists, matching expert models in resource-limited settings. @sysu_1924 #OpenAccess: bio-integration.org/deep-learning-…

Highlighting results from the Phase 3 SLIMMER trial, this review discusses #Ecnoglutide as a novel cAMP-biased GLP-1 receptor agonist that through cAMP-biased #Agonism achieves significant, dose-dependent weight loss offering a #PrecisionPharmacology approach to treating #Obesity. #OpenAccess: bio-integration.org/glp1ra-ecnoglu…

This study demonstrates a portable, non-invasive #BrainSpinalInterface that decodes #humanmotion intentions to control #SpinalStimulation, inducing leg movements in a macaque—showcasing a breakthrough toward restoring locomotion in #Paralysis rehabilitation. #EpiduralElectricalStimulation #SpinalCordInjury @HainanUniversiy #OpenAccess: bio-integration.org/brainspinal-in…

This review highlights how living cells—leveraging #tumor #chemotaxis, #microenvironment modulation, and innate #radiosensitizing abilities—offer innovative solutions to overcome #RadiotherapyResistance and enhance tumor-targeted treatment. #OpenAccess: bio-integration.org/living-cells-t…

Oncolytic Virus Rewires Immune Defense in Brain Tumors Engineered herpes virus boosts antitumor immunity and prolongs survival in preclinical #glioblastoma models @QuintanaLabHMS @MassGeneralNews #braintumors #HSV1 #immuneresponse hubs.li/Q03XgP-K0

Metabolic Shift: DCA increased maximal oxygen consumption and decreased lactate secretion in T cells. This metabolic reprogramming promotes mucosal immune regulation. Novel therapeutic strategy for IBD. bit.ly/3KPfTK3

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