SCAN Lab

Excited and proud to have that monumental team effort published today in Lancet Psychiatry. @gao_yidian and @MStaginnus were partners in crime to lead it, but also had the generous support and contribution from 104 international collaborators from Europe, the US, India, & China.

Fantastic opportunity to work on amazing project with a great mentor!

New #SAMBAlab paper! @JosiDriessen used computational modelling and EEG to study how psychopathic traits are linked to learning what to choose when using social vs. reward information. w/@cognemo_andreea @D_Atanassova. @SSSpsychopathy @decisioncenter 👀👉rdcu.be/exNYf

Expressions of interest now open for (free) places at our symposium on potential for OPM-MEG for research in clinical populations. Friday Sept 19th @InstituteMH, funded by @BritishNeuro Further details here: institutemh.org.uk/events/event/2… @NottsHealthcare @MedicineUoN @SCAN_Lab

Final call to UK and international candidates (Closing date: 2nd March 2025)! Join us as Full Professor in Human/Cognitive/Translational Neuroscience with the opportunity to step in as (Co-)Director at the @TheCHBH 👇 edzz.fa.em3.oraclecloud.com/hcmUI/Candidat… please share

Another great set of papers with @Jul_Dugre focusing on aggression this time! Take a look as there is some really cool stuff!

🚨Job Alert 🚨 Chair in Human/Cognitive/Translational Neuroscience This is a unique opportunity to join a world-class research community on a beautiful campus located in a very nice city! Deadline is 2nd March 2025. Please retweet. Thank you.

Less than 1 week to go until the deadline for those studentships.

Congratulations 🥳 Nice way to end the year!

@DaniqueSmeijers @IntiBrazil @PsychopathyIs Congratulations 🥳

Honored and grateful to receive the 2024 Award for Research on Disorders of Aggression 👇 @IntiBrazil @PsychopathyIs

🚨2 fully-funded PhD studentships🚨 1. Antisocial brains via @enigmabrains 2. Neuroimaging genetics and epigenetics of threat and reward circuitry Open to international students. Deadline 16/01/25 tinyurl.com/44u5mf29 Please RT. @TheCHBH @UoB_SoP @MIBTP_BBSRC @BBSRC

@gao_yidian @daviniaferes @martinw3141 Congratulations 🥳 @gao_yidian

Honored to present the preliminary results of the mTBI-Predict MRI data today and thrilled to receive the Best Presentation by an Early Career Researcher Award! 🥳Huge thanks to @daviniaferes, Karen, Andy, @martinw3141, Ruwan, Iman, and everyone involved in this incredible project. (Apologies for missing a chance to capture photos with you all!)☺️

COME JOIN US in Phoenix tomorrow @ 1pm for ACNP’s “Teaching Day - Big Data: Access, Tools, Applications” #ACNP2024 featuring Damien Fair + Helen Mayberg (+me if I get to Phoenix in time !!!)

@PTenigma Safe travels! Hopefully Arizona will be a bit warmer 😉

Now in Amsterdam but I have to give a talk in Arizona at lunchtime tomorrow. :)

Hi #ACNP2024 ! 👋 - I'm Paul Thompson, attending ACNP on+off since 1998 (ikr?!), ENIGMA consortium PI since 2009. We study human 🧠 disorders w/ imaging. Happy to chat science, careers, frustrations, team projects, anything really ;) Come say hi @ our session Wed w/ Damien Fair+Helen Mayberg.

Thank you @PTenigma It was an absolute pleasure hosting you and thank you for the terrific talk! And yes, let's hope we can welcome you and the @enigmabrains back next year on our lovely campus! @TheCHBH @UoB_SoP @LES_UniBham

@PTenigma safe drive!

The car rental man was not impressed when I got in the wrong side of the car

Fantastic 2 days meeting @enigmabrains discussing data & developments across multiple working groups focusing on psychiatric & neurodevelopmental disorders in youths. Great talk @TownendSophie on the cross-disorder findings! @MStaginnus @Jul_Dugre @gao_yidian @CAM_Cecil

Today's ENIGMA Summit compared over 20 brain disorders in tens of thousands of people scanned with MRI, and suggests that: 1. brain disorders that hit very early, before birth (e.g. those due to genomic copy number variants such as genetic deletions) tend to affect cortical surface area, often excessively in primary sensorimotor cortex 2. neurodevelopmental brain disorders that hit after birth but before adolescence tend to reduce cortical surface area more than (i.e. with greater effect sizes than) they reduce cortical thickness but more in a transmodal association cortex pattern than a primary sensorimotor pattern; these can be split into an strong externalizing and a weak internalizing pattern depending on the disorder type [4] 3. brain disorders that hit after puberty tend to affect cortical thickness, more so than regional cortical surface area, with some exceptions, as do adult onset disorders 4. the last category of mainly-thickness-deficit disorders can have their abnormality decomposed into 3 components - (1) a general component common to all disorders (PC1 in Zhipeng Cao's work [2]), (2) a disorder specific component, and (3) a medication effect; 5. focusing on the first two of these, there is a transdiagnostic covariance [1] that spans the set of disorder effects on the cortex and consists of 2 primary axes of disturbance, G1 and G2 6. to some extent, the amount and anatomical distribution of structural brain deviation in a disorder depends on the location and profile of greatest normal age-related brain change that is normally occurring in healthy people when the disorder hits and can look like an exaggerated version of that change, i.e. 'aging' 7. some of this is set out more formally in the transdiagnostic ENIGMA papers by Meike Hettwer/Sofie Valk on transdiagnostic covariance [1] and brain gradients, and in the linear PCA paper by Zhipeng Cat Hugh Garavan and ENIGMA [2]. For the CNV part see work by Clara Moreau [3], and for the childhood part see work by Sophie Townend and 4 of the ENIGMA neurodevelopmental working groups [unpublished except an abstract]. This is not really obvious until you see all the work presented together (as it was today at the ENIGMA Summit). Links in the thread below. @sofievalk @MMG_Kirschner @ClaraMoreau9 @JulioVillaln1 @kkumar_iitkgp @enigma_bipolar @ENIGMA_Diabetes @ENIGMA_ACRI @SCAN_Lab

Brilliant to catch up with so many amazing people at Day 1 of the ENIGMA Leadership Summit in Amsterdam ! @enigmabrains