Cell Biology

Single-cell ATAC-seq Reveals OVOL2 as a Downstream Negative Regulator of PRL-Mediated Chromatin Accessibility Ruiz Otero, N. D., Chung, J.-Y., Banerjee, R. R. biorxiv.org/content/10.648…

Targeting TPO/MPL Signaling to Mitigate JAK2V617F-driven Cardiac Microvascular Disease Yang, X., Masarik, K., Sun, X., Zhang, F., Zheng, K., Zheng, H., Zhan, H. biorxiv.org/content/10.648…

Atf3 Integrates Lipid and Cytoskeletal Remodeling to Drive Macrophage Fusion Correia, A., Mroueh, N., Wollert, E. K., Stankovic, D., Csordas, G., Juengst, C., Tartiere, A. G.-B., Gomes, M., Iden, S., Uhlirova, M. biorxiv.org/content/10.648…

Spatiotemporal organization of dynein in bulk cytoplasm promotes aster growth and positioning in large embryos Kiyomitsu, A., Bai, L., Mitchison, T., Kiyomitsu, T. biorxiv.org/content/10.648…

New three-dimensional preclinical models to understand and treat liver cancers activated for the β-catenin pathway Bou Malham, V., Leandre, F., Hamimi, A., Lagoutte, I., Bouchet, S., Gougelet, A., Colnot, S., Desbois-Mouthon, C. biorxiv.org/content/10.648…

The role of N-glycans and their processing in ER-to-lysosome-associated degradation of disease-causing mutant Neuroserpin Fregno, I., Hoefner, C., Molinari, M. biorxiv.org/content/10.648…

Unconventional Interplay Between GPCRs and RTKs Signaling Pathways Through SH2 Domain-Containing Proteins Scarpelli Pereira, P. H., Mancini, A., Sidiki Traore, B., Kobayashi, H., Lukasheva, V., LeGouill, C., Sabbagh, L., Bouvier, M. biorxiv.org/content/10.648…

Cholesterol-dependent lysosomal docking of mTORC1 mediated by TM6SF1 Hong, S., Jia, L., Wang, R., Elghobashi-Meinhardt, N., Hobbs, H. H., Li, X. biorxiv.org/content/10.648…

A Novel VWF Knockout Endothelial Cell Model to Study Von Willebrand Factor Biology and Von Willebrand Disease Mechanisms Baer, I., Burgisser, P., Ardic, B., Eikenboom, J., Voorberg, J., Leebeek, F., Bierings, R. biorxiv.org/content/10.648…

A stage-resolved map of dynamic septin interactions required for infection by the rice blast fungus Eisermann, I., Sahu, N., Garduno-Rosales, M., Derbyshire, P., Menke, F. L. H., Ma, W., Talbot, N. J. biorxiv.org/content/10.648…

The epidermal stem cell-supporting matricellular protein fibulin 7 modulates skin inflammatory response in a psoriasis model Raja, E., Machida, T., Narenmandula, N., Edlund, K., Hossain, A. S., Fan, W., Tsunezumi, J., Watanabe, Y., Asano, K., ... biorxiv.org/content/10.648…

DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons Hughes, J.-W. B., Sandholm, A., Croll, D., Senchyna, F., Schneider, K., Butterfield, R., McHugh, T. L. M., Brown, I., Deguchi, H., Hilsabeck, T. A. U., Mak, S., ... biorxiv.org/content/10.648…

STI1 domains coordinate partitioning of UBQLN2 into stress-induced condensates Haws, B., Dao, T. P., Varner, B., Jones, H. B., Brown, M. P., Castaneda, C. A. biorxiv.org/content/10.648…

AI-Driven Reconstruction of the Research Paradigm for Phase Separation in Membraneless Organelle ding, y., lu, t., Li, y. biorxiv.org/content/10.648…

Metabolostasis failure thresholds are linked with network topology, metabolite solubility, and translational control A. Levkovich, S., M Lim, C., A. Marzini, E., Adsi, H., Lahav, M., Sogolovsky-Bard, I., Gartner, M., Kaplan, K., DeRowe, Y., ... biorxiv.org/content/10.648…

Ovarian extracellular matrix mechanics regulate oocyte-follicle interactions during female reproductive aging Shen, X., Wang, H., Cao, G., Lee, Y., Zhu, J., Wang, L. C., Zhao, T., Ler, S. G., Sobota, R. M., Li, R., Young, J. L. biorxiv.org/content/10.648…

SHOT-CCR: Biologically guided adversarial training for test-time adaptation in cellular morphology Dee, W., Wenteler, A., Seal, S., Morris, O., Slabaugh, G. biorxiv.org/content/10.648…

Genetic dissection of rapid proteolysis identifies TXNDC15 as a key factor of ERAD and lipid homeostasis Liu, Y., Yaochai, M. Y., Liu, S., Alwaseem, H., Birsoy, K. biorxiv.org/content/10.648…

A non-invasive approach for understanding localized force generation in 3D tissues Gouirand, N., Ibrahimi, M., Valotteau, C., Lecouffe, B., Le Bivic, A., Massey Harroche, D., Rico, F., Merkel, M., Delacour, D., Bazellieres, E. biorxiv.org/content/10.648…

Generative machine learning unlocks the first proteome-wide image of human cells Sun, H., Kahnert, K., Hansen, J. N., Leineweber, W. D., Li, M., Feng, W., Ballllosera Navarro, F., Axelsson, U., Ouyang, W., Lundberg, E. biorxiv.org/content/10.648…