This illustrates the need to complement current non-clinical #toxicology assessments with human model systems for #nucleicacid targeting #medicinalproducts. #science
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Winner_Lab
638 posts
Winner_Lab
@WinnerLab
Research group of Beate Winner 👩🏼🎓, focusing on disease modeling of neurodegeneration using hiPSCs. 👩🏼🔬🧠 @UniFAU (posts from lab members)
Erlangen, Deutschland Joined Haziran 2019
465 Following554 Followers
In this use case we leveraged the power of #iPSC-derived #neurons and were able to recapitulate adverse event findings arising in #HuntingtonsDisease patients during a #clinicaltrial.
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Happy to share that our work on in vitro neurotoxicology assessment of an #RNA splicing modulator was published in #iScience:
cell.com/iscience/fullt…
Joint work with Tom Boerstler, Florian Krach, Jürgen Winkler and Beate Winner 🚀
@Molecular_Neuro @UniFAU
#WinnerLab
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Great event organized by a team around our wonderful @NaimeZagha
Followed by a discussion with experts and patients 🧑🏻⚕️
@CRU_GB_Com @MIB_GuentherLab
Klara Metzner@klarametzner
Happy to have met @Hornegger at the theatre play “Kleine Schritte” at E-Werk, Erlangen 🎭 Highlighting the importance of #Parkinsons research @WinnerLab @CRU_GB_Com 🔬🧫
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Winner_Lab retweeted
Alpha synulcien targeting NPT100-18A rescues mitochondrial oxidative stress & neuronal degeneration in human iPSC-based #Parkinsons; First mechanistic insights into how a compartment-specific antioxidant effect in mitochondria might be involved in MoA
bmcneurosci.biomedcentral.com/articles/10.11…
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Winner_Lab retweeted
Very excited that our study in #BMCNeuroscience @BioMedCentral is out! We provide the first insights into the compartment-specific protective effects of #alphasynuclein anti-oligomerisation compounds in human dopaminergic neurons in the context of #ParkinsonsDisease. @WinnerLab
The Science of Parkinson's@ScienceofPD
Alpha synulcien targeting NPT100-18A rescues mitochondrial oxidative stress & neuronal degeneration in human iPSC-based #Parkinsons; First mechanistic insights into how a compartment-specific antioxidant effect in mitochondria might be involved in MoA bmcneurosci.biomedcentral.com/articles/10.11…
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Winner_Lab retweeted
🌟Join us at the 3rd International Symposium: Developmental Processes in CNS Plasticity and Pathogenesis!🌟
🗓️April 9-11, 2025
📍Erlangen, Germany
✏️Register here: bit.ly/4jvs4Z5
#Neurogenesis #DevelopmentalBiology #NeuralCircuit #CNSdisorders #GRK2162 #Symposium
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Winner_Lab retweeted
We are excited to introduce first-of-a-kind immunofluorescent probes to visualize RNA in cells! @NAR_Open
Synthetic anti-RNA antibody derivatives for RNA visualization in mammalian cells academic.oup.com/nar/article/do…
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Winner_Lab retweeted
An integrated transcriptomic cell atlas of human neural organoids | Nature nature.com/articles/s4158…
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Winner_Lab retweeted
The position is still available!! Plz RT and apply!! Send DM
Tomohisa Toda@TomohisaToda
#JobAlert join us as a ERC-funded postdoc to uncovered long-lived RNA dependent epigenetic regulation in brain aging @UniFAU,@MPZ_PhysMed, #RNA #chromatin #epigenome #aging. Plz check todalab.com. Dm if you are interested in. And Plz RT!!!
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The Toda lab @TomohisaToda is now @MPZ_PhysMed !! Thank u everyone who made it possible to be there including @Franze_Lab , @GuckLab @UniFAU & twitterless others ;) now the lab is on fire for fruitful discussion 🤓
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Winner_Lab retweeted
Altered mRNA transport and local translation in iNeurons with RNA binding protein knockdown
biorxiv.org/content/10.110…
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Looking back at our #ScienceSlam last night @ewerk_erlangen 🚀💪🏻
Thanks to everyone who joined us, thanks to the moderator @schroep, the organization team @CRU_GB_Com, and of course a huge thank you to the slammers!
@krummla @bruno_ghirotto @DuarteLEG @vivien_ruder @klarametzner
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Feeling happy and honored to join FAU Erlangen as a professor for Nanooptical Imaging - I cannot wait to continue and expand our research at the intersection of advanced optics, glycobiology, and biomedicine in this truly inspiring and vibrant environment!
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Winner_Lab retweeted
Winner_Lab retweeted
Physics 🤝 medicine
Scientists specializing in physics, biology & medicine will be working at the Max-Planck-Zentrum für Physik und Medizin (MPZPM) to shape the future of medical research.
In 7 days, we will be celebrating the opening of the MPZPM!
👉bit.ly/About-MPZPM
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Winner_Lab retweeted
The event will be in English. Tickets available from September 10th—grab yours quickly as spots are limited. Free entry! Tickets at: eveeno.com/gb-forinter-sc…
@WinnerLab @MIB_GuentherLab @UniFAU
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Winner_Lab retweeted
🚀Our 2021 Science Slam was a hit with 500+ attendees!🎉Now, join us on #September24th at 6 p.m. at E-Werk Erlangen for more exciting discoveries! 🎙️ Scientists 👨🔬👩🔬 will dive into stem cell biology 🔬 and gut-brain communication, plus some fun surprises ;)#ScienceSlam
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