WredenbergLab

Our study on how mitochondrial methylation shapes gene expression is now out. Using long-read RNAseq and cryo-EM, we uncover two methylation-dependent checkpoints in ribosome biogenesis. Read all about it at: rdcu.be/etk12

Our newest paper on mitochondrial Topoisomerase 1 shows that Top1mt has only weak endoribonuclease activity and it therefore does not often generate deletions at incorporated ribonucleotides. This helps explain why ribonucleotides are tolerated in mtDNA. academic.oup.com/nar/article-ab…

New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration. nature.com/articles/s4158…

Interested in mitochondrial biology? We are looking for an enthusiastic PostDoctoral fellow and PhD student to join our group in Stockholm. @mitojobs @MolMet_KI For the PhD position: kidoktorand.varbi.com/what:job/jobID… For the PostDoc position: ki.varbi.com/what:job/jobID…

Check out our recent paper showing how maternal inheritance of mtDNA is guaranteed in D. melanogaster.

I'm excited to share our latest work linking TAG mobilization to mitochondrial stress recovery. A monumental effort by @Zak_Bakes (on the faculty job market soon!). Great collaboration with the @Coon_Labs and others. rdcu.be/d5ACF #mitochondria #HHMINews

The peer-reviewed version of our paper on human tRNA 3' processing is now published in @NatureSMB. Many thanks to the reviewers for their constructive comments! nature.com/articles/s4159… See also the very nice related work by @BMartinHallberg @no1gv: embopress.org/doi/full/10.10…

New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability. Thanks to all authors for their contributions and the reviewers for their kind advice! academic.oup.com/nar/article/do… #RNA #mitochondria #mtDNA

@Ella_Maru @labs_mann @NatureComms @metaboflo That’s a good question that our fly model can’t answer. Our data indicates that the chronic and excessive activation of autophagy contributes to mitochondrial dysfunction. Whether this also drives the age-related mitochondrial decline we will test in a different model system.

@WredenbergLab @labs_mann @NatureComms @metaboflo Congratulations, Prof. Wredenberg & team! Can the mitochondrial rescue pathways also mitigate aging-related mtDNA damage?

We are excited to share our latest work on mechanisms that protect from mitochondrial dysfunction. Thank you to all collaborators and the 4th anonymous reviewer for supporting us. @labs_mann @NatureComms @metaboflo #Sec37" target="_blank" rel="nofollow noopener">nature.com/articles/s4146…

We performed a genetic screen in fruit flies and identified several pathways that can rescue a lethal phenotype of mtDNA mutator flies. Looking forward to testing this in a higher species.

We argued that since the accumulation of mtDNA mutations is progressive, there must be cellular mechanisms that affect their pathogenicity.

Just over a week left to apply for a PostDoc position in mitochondrial biology with us. #mitochondria @mitojobs ki.varbi.com/ny/what:job/jo…

We have 1-2 PostDoc positions for enthusiastic researchers interested in mitochondrial biology. Apply here. #mitochondria #mitojobs ki.varbi.com/ny/what:job/jo…

Using nanopore RNAseq and cryoEM on SAMC KO MEFs and skel muscle we show that SAM is crucial for mt-rRNA processing and mitoribosome assembly. #mitochondria.

Our study on methylation during mitochondrial gene expression is now online. Great effort by @ruth_icg, Vivek Singh, @A_Amunts, and @MolMet_KI. biorxiv.org/content/10.110…

Extremely proud to share our integrative work on how 'Dissected antiporter modules establish the minimal proton-conducting elements in Complex I' – now out in Nature Comms! Many thanks to @KAWstiftelsen & @Vetenskapsradetfor funding. nature.com/articles/s4146…

🚨Mitochondrial research out🚨 Our latest work on the synergy between LRPPRC and SLIRP for maintaining mtDNA gene expression in vivo is now published! 🧬 Free-access link to the article: academic.oup.com/nar/article/52…

Happy to share our latest manuscript on using quantitative proteomics to diagnose patients with mitochondrial disease. Great collaboration with @taylorlabncl and @lukas_k insight.jci.org/articles/view/…

We are excited to share our lab's first preprint, highlighting the role of the CHCHD2-CHCHD10 complex in preserving tissue homeostasis. A huge thank you to all our collaborators! biorxiv.org/content/10.110…